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Tetracycline-encapsulated P(3HB) microsphere-coated 45S5 Bioglass^sup ^-based scaffolds for bone tissue engineering

Bioglass^sup ^-based scaffolds for bone tissue engineering have been developed, which can also serve as carriers for drug delivery. For this, P(3HB) microspheres (PMSs) loaded with tetracycline were fabricated and immobilised on the scaffold surfaces by a modified slurry dipping technique. The susta... Full description

Journal Title: Journal of Materials Science : Materials in Medicine Dec 2013, Vol.24(12), pp.2809-17
Main Author: Meng, D
Other Authors: Francis, L , Thompson, I , Mierke, C , Huebner, H , Amtmann, A , Roy, I , Boccaccini, A
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 09574530 ; DOI: 10.1007/s10856-013-5012-4
Link: http://search.proquest.com/docview/1459330797/?pq-origsite=primo
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title: Tetracycline-encapsulated P(3HB) microsphere-coated 45S5 Bioglass^sup ^-based scaffolds for bone tissue engineering
format: Article
creator:
  • Meng, D
  • Francis, L
  • Thompson, I
  • Mierke, C
  • Huebner, H
  • Amtmann, A
  • Roy, I
  • Boccaccini, A
subjects:
  • Animals–Administration & Dosage
  • Anti-Bacterial Agents–Chemistry
  • Anti-Bacterial Agents–Chemistry
  • Bone Substitutes–Chemistry
  • Bone & Bones–Chemistry
  • Ceramics–Cytology
  • Coated Materials, Biocompatible–Chemistry
  • Drug Carriers–Administration & Dosage
  • Drug Delivery Systems–Chemistry
  • Fibroblasts–Methods
  • Glass–Methods
  • Materials Testing–Methods
  • Mice–Methods
  • Microspheres–Methods
  • Tetracycline–Methods
  • Tetracycline–Methods
  • Tetrazolium Salts–Methods
  • Thiazoles–Methods
  • Tissue Engineering–Methods
  • Tissue Scaffolds–Methods
  • Antibiotics
  • Bones
  • Materials Science
  • Biomedical Materials
  • Tissue Engineering
  • Anti-Bacterial Agents
  • Bone Substitutes
  • Ceramics
  • Coated Materials, Biocompatible
  • Drug Carriers
  • Tetrazolium Salts
  • Thiazoles
  • Bioactive Glass 45s5
  • Thiazolyl Blue
  • Tetracycline
ispartof: Journal of Materials Science : Materials in Medicine, Dec 2013, Vol.24(12), pp.2809-17
description: Bioglass^sup ^-based scaffolds for bone tissue engineering have been developed, which can also serve as carriers for drug delivery. For this, P(3HB) microspheres (PMSs) loaded with tetracycline were fabricated and immobilised on the scaffold surfaces by a modified slurry dipping technique. The sustained drug delivery ability in simulated body fluid was confirmed by using UV-Vis absorption spectroscopy measurements. The MTT assay using mouse fibroblast cells provided evidence that the tetracycline loaded microspheres produced in this study show limited cytotoxicity. The scaffolds developed in this work provide mechanical support, adequate 3D surface roughness, bioactivity and controlled drug delivery function, and are thus interesting candidates for bone tissue engineering applications.[PUBLICATION ]
language: eng
source:
identifier: ISSN: 09574530 ; DOI: 10.1007/s10856-013-5012-4
fulltext: fulltext
issn:
  • 09574530
  • 0957-4530
url: Link


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titleTetracycline-encapsulated P(3HB) microsphere-coated 45S5 Bioglass^sup ^-based scaffolds for bone tissue engineering
creatorMeng, D ; Francis, L ; Thompson, I ; Mierke, C ; Huebner, H ; Amtmann, A ; Roy, I ; Boccaccini, A
ispartofJournal of Materials Science : Materials in Medicine, Dec 2013, Vol.24(12), pp.2809-17
identifierISSN: 09574530 ; DOI: 10.1007/s10856-013-5012-4
subjectAnimals–Administration & Dosage ; Anti-Bacterial Agents–Chemistry ; Anti-Bacterial Agents–Chemistry ; Bone Substitutes–Chemistry ; Bone & Bones–Chemistry ; Ceramics–Cytology ; Coated Materials, Biocompatible–Chemistry ; Drug Carriers–Administration & Dosage ; Drug Delivery Systems–Chemistry ; Fibroblasts–Methods ; Glass–Methods ; Materials Testing–Methods ; Mice–Methods ; Microspheres–Methods ; Tetracycline–Methods ; Tetracycline–Methods ; Tetrazolium Salts–Methods ; Thiazoles–Methods ; Tissue Engineering–Methods ; Tissue Scaffolds–Methods ; Antibiotics ; Bones ; Materials Science ; Biomedical Materials ; Tissue Engineering ; Anti-Bacterial Agents ; Bone Substitutes ; Ceramics ; Coated Materials, Biocompatible ; Drug Carriers ; Tetrazolium Salts ; Thiazoles ; Bioactive Glass 45s5 ; Thiazolyl Blue ; Tetracycline
descriptionBioglass^sup ^-based scaffolds for bone tissue engineering have been developed, which can also serve as carriers for drug delivery. For this, P(3HB) microspheres (PMSs) loaded with tetracycline were fabricated and immobilised on the scaffold surfaces by a modified slurry dipping technique. The sustained drug delivery ability in simulated body fluid was confirmed by using UV-Vis absorption spectroscopy measurements. The MTT assay using mouse fibroblast cells provided evidence that the tetracycline loaded microspheres produced in this study show limited cytotoxicity. The scaffolds developed in this work provide mechanical support, adequate 3D surface roughness, bioactivity and controlled drug delivery function, and are thus interesting candidates for bone tissue engineering applications.[PUBLICATION ]
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titleTetracycline-encapsulated P(3HB) microsphere-coated 45S5 Bioglass^sup ^-based scaffolds for bone tissue engineering
descriptionBioglass^sup ^-based scaffolds for bone tissue engineering have been developed, which can also serve as carriers for drug delivery. For this, P(3HB) microspheres (PMSs) loaded with tetracycline were fabricated and immobilised on the scaffold surfaces by a modified slurry dipping technique. The sustained drug delivery ability in simulated body fluid was confirmed by using UV-Vis absorption spectroscopy measurements. The MTT assay using mouse fibroblast cells provided evidence that the tetracycline loaded microspheres produced in this study show limited cytotoxicity. The scaffolds developed in this work provide mechanical support, adequate 3D surface roughness, bioactivity and controlled drug delivery function, and are thus interesting candidates for bone tissue engineering applications.[PUBLICATION ]
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1Anti-Bacterial Agents–Chemistry
2Bone Substitutes–Chemistry
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titleTetracycline-encapsulated P(3HB) microsphere-coated 45S5 Bioglass^sup ^-based scaffolds for bone tissue engineering
authorMeng, D ; Francis, L ; Thompson, I ; Mierke, C ; Huebner, H ; Amtmann, A ; Roy, I ; Boccaccini, A
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1Anti-Bacterial Agents–Chemistry
2Bone Substitutes–Chemistry
3Bone & Bones–Chemistry
4Ceramics–Cytology
5Coated Materials, Biocompatible–Chemistry
6Drug Carriers–Administration & Dosage
7Drug Delivery Systems–Chemistry
8Fibroblasts–Methods
9Glass–Methods
10Materials Testing–Methods
11Mice–Methods
12Microspheres–Methods
13Tetracycline–Methods
14Tetrazolium Salts–Methods
15Thiazoles–Methods
16Tissue Engineering–Methods
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18Antibiotics
19Bones
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21Biomedical Materials
22Tissue Engineering
23Anti-Bacterial Agents
24Bone Substitutes
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28Tetrazolium Salts
29Thiazoles
30Bioactive Glass 45s5
31Thiazolyl Blue
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12Civil Engineering Abstracts
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abstractBioglass^sup ^-based scaffolds for bone tissue engineering have been developed, which can also serve as carriers for drug delivery. For this, P(3HB) microspheres (PMSs) loaded with tetracycline were fabricated and immobilised on the scaffold surfaces by a modified slurry dipping technique. The sustained drug delivery ability in simulated body fluid was confirmed by using UV-Vis absorption spectroscopy measurements. The MTT assay using mouse fibroblast cells provided evidence that the tetracycline loaded microspheres produced in this study show limited cytotoxicity. The scaffolds developed in this work provide mechanical support, adequate 3D surface roughness, bioactivity and controlled drug delivery function, and are thus interesting candidates for bone tissue engineering applications.[PUBLICATION ABSTRACT]
copLondon
pubSpringer Science & Business Media
doi10.1007/s10856-013-5012-4
urlhttp://search.proquest.com/docview/1459330797/
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date2013-12-01