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Intranasal LPS-mediated Parkinson's model challenges the pathogenesis of nasal cavity and environmental toxins.

Accumulating evidence implicates the relationship between neuroinflammation and pathogenesis in idiopathic Parkinson's disease (iPD). The nose has recently been considered a gate way to the brain which facilitates entry of environmental neurotoxin into the brain. Our study aims to build a PD model b... Full description

Journal Title: PloS one 2013, Vol.8(11), p.e78418
Main Author: He, Qing
Other Authors: Yu, Wenbo , Wu, Jianjun , Chen, Chan , Lou, Zhiyin , Zhang, Qiong , Zhao, Jian , Wang, Jian , Xiao, Baoguo
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1932-6203 ; DOI: 1932-6203 ; DOI: 10.1371/journal.pone.0078418
Link: http://search.proquest.com/docview/1459972488/?pq-origsite=primo
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title: Intranasal LPS-mediated Parkinson's model challenges the pathogenesis of nasal cavity and environmental toxins.
format: Article
creator:
  • He, Qing
  • Yu, Wenbo
  • Wu, Jianjun
  • Chen, Chan
  • Lou, Zhiyin
  • Zhang, Qiong
  • Zhao, Jian
  • Wang, Jian
  • Xiao, Baoguo
subjects:
  • Animals–Metabolism
  • Dopamine–Drug Effects
  • Dopaminergic Neurons–Pathology
  • Hazardous Substances–Toxicity
  • Humans–Chemically Induced
  • Inflammation–Pathology
  • Lipopolysaccharides–Toxicity
  • Mice–Drug Effects
  • Microglia–Pathology
  • Nasal Cavity–Drug Effects
  • Olfactory Receptor Neurons–Drug Effects
  • Parkinson Disease–Pathology
  • Parkinson Disease–Pathology
  • Hazardous Substances
  • Lipopolysaccharides
  • Dopamine
ispartof: PloS one, 2013, Vol.8(11), p.e78418
description: Accumulating evidence implicates the relationship between neuroinflammation and pathogenesis in idiopathic Parkinson's disease (iPD). The nose has recently been considered a gate way to the brain which facilitates entry of environmental neurotoxin into the brain. Our study aims to build a PD model by a natural exposure route. In this report, we establish a new endotoxin-based PD model in mice by unilateral intranasal (i.n.) instillation of the lipopolysaccharides (LPS) every other day for 5 months. These mice display a progressive hypokinesia, selective loss of dopaminergic neurons, and reduction in striatal dopamine (DA) content, as well as [alpha]-synuclein aggregation in the SN, without systemic inflammatory and immune responses. This new PD model provides a tool for studying the inflammation-mediated chronic pathogenesis and searching for therapeutic intervention in glia-neuron pathway that will slow or halt neurodegeneration in PD.
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 1932-6203 ; DOI: 10.1371/journal.pone.0078418
fulltext: fulltext
issn:
  • 19326203
  • 1932-6203
url: Link


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titleIntranasal LPS-mediated Parkinson's model challenges the pathogenesis of nasal cavity and environmental toxins.
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descriptionAccumulating evidence implicates the relationship between neuroinflammation and pathogenesis in idiopathic Parkinson's disease (iPD). The nose has recently been considered a gate way to the brain which facilitates entry of environmental neurotoxin into the brain. Our study aims to build a PD model by a natural exposure route. In this report, we establish a new endotoxin-based PD model in mice by unilateral intranasal (i.n.) instillation of the lipopolysaccharides (LPS) every other day for 5 months. These mice display a progressive hypokinesia, selective loss of dopaminergic neurons, and reduction in striatal dopamine (DA) content, as well as [alpha]-synuclein aggregation in the SN, without systemic inflammatory and immune responses. This new PD model provides a tool for studying the inflammation-mediated chronic pathogenesis and searching for therapeutic intervention in glia-neuron pathway that will slow or halt neurodegeneration in PD.
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