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Causal interactions between fronto-parietal central executive and default-mode networks in humans.

Information processing during human cognitive and emotional operations is thought to involve the dynamic interplay of several large-scale neural networks, including the fronto-parietal central executive network (CEN), cingulo-opercular salience network (SN), and the medial prefrontal-medial parietal... Full description

Journal Title: Proceedings of the National Academy of Sciences of the United States of America December 3, 2013, Vol.110(49), pp.19944-19949
Main Author: Chen, Ashley C
Other Authors: Oathes, Desmond J , Chang, Catie , Bradley, Travis , Zhou, Zheng-Wei , Williams, Leanne M , Glover, Gary H , Deisseroth, Karl , Etkin, Amit
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1091-6490 ; DOI: 10.1073/pnas.1311772110
Link: http://search.proquest.com/docview/1465178374/?pq-origsite=primo
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title: Causal interactions between fronto-parietal central executive and default-mode networks in humans.
format: Article
creator:
  • Chen, Ashley C
  • Oathes, Desmond J
  • Chang, Catie
  • Bradley, Travis
  • Zhou, Zheng-Wei
  • Williams, Leanne M
  • Glover, Gary H
  • Deisseroth, Karl
  • Etkin, Amit
subjects:
  • Adult–Physiology
  • Executive Function–Physiology
  • Female–Physiology
  • Frontal Lobe–Physiology
  • Humans–Physiology
  • Magnetic Resonance Imaging–Physiology
  • Male–Physiology
  • Mental Processes–Physiology
  • Nerve Net–Physiology
  • Parietal Lobe–Physiology
  • Transcranial Magnetic Stimulation–Physiology
  • Fmri
  • Neuromodulation
  • Task Negative Network
  • Task Positive Network
ispartof: Proceedings of the National Academy of Sciences of the United States of America, December 3, 2013, Vol.110(49), pp.19944-19949
description: Information processing during human cognitive and emotional operations is thought to involve the dynamic interplay of several large-scale neural networks, including the fronto-parietal central executive network (CEN), cingulo-opercular salience network (SN), and the medial prefrontal-medial parietal default mode networks (DMN). It has been theorized that there is a causal neural mechanism by which the CEN/SN negatively regulate the DMN. Support for this idea has come from correlational neuroimaging studies; however, direct evidence for this neural mechanism is lacking. Here we undertook a direct test of this mechanism by combining transcranial magnetic stimulation (TMS) with functional MRI to causally excite or inhibit TMS-accessible prefrontal nodes within the CEN or SN and determine consequent effects on the DMN. Single-pulse excitatory stimulations delivered to only the CEN node induced negative DMN connectivity with the CEN and SN, consistent with the CEN/SN's hypothesized negative regulation of the DMN. Conversely, low-frequency inhibitory repetitive TMS to the CEN node resulted in a shift of DMN signal from its normally low-frequency range to a higher frequency, suggesting disinhibition of DMN activity. Moreover, the CEN node exhibited this causal regulatory relationship primarily with the medial prefrontal portion of the DMN. These findings significantly advance our understanding of the causal mechanisms by which major brain networks normally coordinate information processing. Given that poorly regulated information processing is a hallmark of most neuropsychiatric disorders, these findings provide a foundation for ways to study network dysregulation and develop brain stimulation treatments for these disorders. task positive network | task negative network | fMRI | neuromodulation www.pnas.org/cgi/doi/10.1073/pnas.1311772110
language: eng
source:
identifier: E-ISSN: 1091-6490 ; DOI: 10.1073/pnas.1311772110
fulltext: fulltext
issn:
  • 10916490
  • 1091-6490
url: Link


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titleCausal interactions between fronto-parietal central executive and default-mode networks in humans.
creatorChen, Ashley C ; Oathes, Desmond J ; Chang, Catie ; Bradley, Travis ; Zhou, Zheng-Wei ; Williams, Leanne M ; Glover, Gary H ; Deisseroth, Karl ; Etkin, Amit
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subjectAdult–Physiology ; Executive Function–Physiology ; Female–Physiology ; Frontal Lobe–Physiology ; Humans–Physiology ; Magnetic Resonance Imaging–Physiology ; Male–Physiology ; Mental Processes–Physiology ; Nerve Net–Physiology ; Parietal Lobe–Physiology ; Transcranial Magnetic Stimulation–Physiology ; Fmri ; Neuromodulation ; Task Negative Network ; Task Positive Network
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descriptionInformation processing during human cognitive and emotional operations is thought to involve the dynamic interplay of several large-scale neural networks, including the fronto-parietal central executive network (CEN), cingulo-opercular salience network (SN), and the medial prefrontal-medial parietal default mode networks (DMN). It has been theorized that there is a causal neural mechanism by which the CEN/SN negatively regulate the DMN. Support for this idea has come from correlational neuroimaging studies; however, direct evidence for this neural mechanism is lacking. Here we undertook a direct test of this mechanism by combining transcranial magnetic stimulation (TMS) with functional MRI to causally excite or inhibit TMS-accessible prefrontal nodes within the CEN or SN and determine consequent effects on the DMN. Single-pulse excitatory stimulations delivered to only the CEN node induced negative DMN connectivity with the CEN and SN, consistent with the CEN/SN's hypothesized negative regulation of the DMN. Conversely, low-frequency inhibitory repetitive TMS to the CEN node resulted in a shift of DMN signal from its normally low-frequency range to a higher frequency, suggesting disinhibition of DMN activity. Moreover, the CEN node exhibited this causal regulatory relationship primarily with the medial prefrontal portion of the DMN. These findings significantly advance our understanding of the causal mechanisms by which major brain networks normally coordinate information processing. Given that poorly regulated information processing is a hallmark of most neuropsychiatric disorders, these findings provide a foundation for ways to study network dysregulation and develop brain stimulation treatments for these disorders. task positive network | task negative network | fMRI | neuromodulation www.pnas.org/cgi/doi/10.1073/pnas.1311772110
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