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Genome-wide association study identifies three novel loci for type 2 diabetes.

Although over 60 loci for type 2 diabetes (T2D) have been identified, there still remains a large genetic component to be clarified. To explore unidentified loci for T2D, we performed a genome-wide association study (GWAS) of 6 209 637 single-nucleotide polymorphisms (SNPs), which were directly geno... Full description

Journal Title: Human molecular genetics January 1, 2014, Vol.23(1), pp.239-246
Main Author: Hara, Kazuo
Other Authors: Fujita, Hayato , Johnson, Todd A , Yamauchi, Toshimasa , Yasuda, Kazuki , Horikoshi, Momoko , Peng, Chen , Hu, Cheng , Ma, Ronald C W , Imamura, Minako , Iwata, Minoru , Tsunoda, Tatsuhiko , Morizono, Takashi , Shojima, Nobuhiro , So, Wing Yee , Leung, Ting Fan , Kwan, Patrick , Zhang, Rong , Wang, Jie , Yu
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1460-2083 ; DOI: 10.1093/hmg/ddt399
Link: http://search.proquest.com/docview/1467634705/?pq-origsite=primo
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title: Genome-wide association study identifies three novel loci for type 2 diabetes.
format: Article
creator:
  • Hara, Kazuo
  • Fujita, Hayato
  • Johnson, Todd A
  • Yamauchi, Toshimasa
  • Yasuda, Kazuki
  • Horikoshi, Momoko
  • Peng, Chen
  • Hu, Cheng
  • Ma, Ronald C W
  • Imamura, Minako
  • Iwata, Minoru
  • Tsunoda, Tatsuhiko
  • Morizono, Takashi
  • Shojima, Nobuhiro
  • So, Wing Yee
  • Leung, Ting Fan
  • Kwan, Patrick
  • Zhang, Rong
  • Wang, Jie
  • Yu
subjects:
  • Diabetes Mellitus, Type 2–Genetics
  • Genetic Loci–Genetics
  • Genetic Predisposition to Disease–Genetics
  • Genetic Variation–Genetics
  • Genome, Human–Genetics
  • Genome-Wide Association Study–Genetics
  • Guanine Nucleotide Dissociation Inhibitors–Genetics
  • Haplotypes–Genetics
  • Humans–Genetics
  • Leptin–Genetics
  • Micrornas–Genetics
  • Monocarboxylic Acid Transporters–Genetics
  • Polymorphism, Single Nucleotide–Genetics
  • Gpsm1 Protein, Human
  • Guanine Nucleotide Dissociation Inhibitors
  • Leptin
  • Micrornas
  • Mirn129 Microrna, Human
  • Monocarboxylic Acid Transporters
  • Slc16a13 Protein, Human
ispartof: Human molecular genetics, January 1, 2014, Vol.23(1), pp.239-246
description: Although over 60 loci for type 2 diabetes (T2D) have been identified, there still remains a large genetic component to be clarified. To explore unidentified loci for T2D, we performed a genome-wide association study (GWAS) of 6 209 637 single-nucleotide polymorphisms (SNPs), which were directly genotyped or imputed using East Asian references from the 1000 Genomes Project (June 2011 release) in 5976 Japanese patients with T2D and 20 829 nondiabetic individuals. Nineteen unreported loci were selected and taken forward to follow-up analyses. Combined discovery and follow-up analyses (30 392 cases and 34 814 controls) identified three new loci with genome-wide significance, which were MIR129-LEP [rs791595; risk allele = A; risk allele frequency (RAF) = 0.080; P = 2.55 × 10(-13); odds ratio (OR) = 1.17], GPSM1 [rs11787792; risk allele = A; RAF = 0.874; P = 1.74 × 10(-10); OR = 1.15] and SLC16A13 (rs312457; risk allele = G; RAF = 0.078; P = 7.69 × 10(-13); OR = 1.20). This study demonstrates that GWASs based on the imputation of genotypes using modern reference haplotypes such as that from the 1000 Genomes Project data can assist in identification of new loci for common diseases.
language: eng
source:
identifier: E-ISSN: 1460-2083 ; DOI: 10.1093/hmg/ddt399
fulltext: fulltext
issn:
  • 14602083
  • 1460-2083
url: Link


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titleGenome-wide association study identifies three novel loci for type 2 diabetes.
creatorHara, Kazuo ; Fujita, Hayato ; Johnson, Todd A ; Yamauchi, Toshimasa ; Yasuda, Kazuki ; Horikoshi, Momoko ; Peng, Chen ; Hu, Cheng ; Ma, Ronald C W ; Imamura, Minako ; Iwata, Minoru ; Tsunoda, Tatsuhiko ; Morizono, Takashi ; Shojima, Nobuhiro ; So, Wing Yee ; Leung, Ting Fan ; Kwan, Patrick ; Zhang, Rong ; Wang, Jie ; Yu
contributorVoight, Benjamin F (correspondence author) ; Scott, Laura J (record owner) ; Steinthorsdottir, Valgerdur ; Morris, Andrew P ; Dina, Christian ; Welch, Ryan P ; Zeggini, Eleftheria ; Huth, Cornelia ; Aulchenko, Yurii S ; Thorleifsson, Gudmar ; Mcculloch, Laura J ; Ferreira, Teresa ; Grallert, Harald ; Amin, Najaf ; Wu, Guanming ; Willer, Cristen J ; Raychaudhuri, Soumya ; Mccarroll, Steve A ; Langenberg, Claudia ; Hofmann
ispartofHuman molecular genetics, January 1, 2014, Vol.23(1), pp.239-246
identifierE-ISSN: 1460-2083 ; DOI: 10.1093/hmg/ddt399
subjectDiabetes Mellitus, Type 2–Genetics ; Genetic Loci–Genetics ; Genetic Predisposition to Disease–Genetics ; Genetic Variation–Genetics ; Genome, Human–Genetics ; Genome-Wide Association Study–Genetics ; Guanine Nucleotide Dissociation Inhibitors–Genetics ; Haplotypes–Genetics ; Humans–Genetics ; Leptin–Genetics ; Micrornas–Genetics ; Monocarboxylic Acid Transporters–Genetics ; Polymorphism, Single Nucleotide–Genetics ; Gpsm1 Protein, Human ; Guanine Nucleotide Dissociation Inhibitors ; Leptin ; Micrornas ; Mirn129 Microrna, Human ; Monocarboxylic Acid Transporters ; Slc16a13 Protein, Human
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descriptionAlthough over 60 loci for type 2 diabetes (T2D) have been identified, there still remains a large genetic component to be clarified. To explore unidentified loci for T2D, we performed a genome-wide association study (GWAS) of 6 209 637 single-nucleotide polymorphisms (SNPs), which were directly genotyped or imputed using East Asian references from the 1000 Genomes Project (June 2011 release) in 5976 Japanese patients with T2D and 20 829 nondiabetic individuals. Nineteen unreported loci were selected and taken forward to follow-up analyses. Combined discovery and follow-up analyses (30 392 cases and 34 814 controls) identified three new loci with genome-wide significance, which were MIR129-LEP [rs791595; risk allele = A; risk allele frequency (RAF) = 0.080; P = 2.55 × 10(-13); odds ratio (OR) = 1.17], GPSM1 [rs11787792; risk allele = A; RAF = 0.874; P = 1.74 × 10(-10); OR = 1.15] and SLC16A13 (rs312457; risk allele = G; RAF = 0.078; P = 7.69 × 10(-13); OR = 1.20). This study demonstrates that GWASs based on the imputation of genotypes using modern reference haplotypes such as that from the 1000 Genomes Project data can assist in identification of new loci for common diseases.
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18Wang, Jie
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31Teo, Yik Ying
32Shyong, Tai E
33Kamatani, Naoyuki
34Kubo, Michiaki
35Maeda, Shiro
36Kadowaki, Takashi
titleGenome-wide association study identifies three novel loci for type 2 diabetes.
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17Mccarroll, Steve A
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19Hofmann, Oliver M
20Dupuis, Josée
21Qi, Lu
22Segrè, Ayellet V
23van Hoek, Mandy
24Navarro, Pau
25Ardlie, Kristin
26Balkau, Beverley
27Benediktsson, Rafn
28Bennett, Amanda J
29Blagieva, Roza
30Boerwinkle, Eric
31Bonnycastle, Lori L
32Bengtsson Boström, Kristina
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34Bumpstead, Suzannah
35Burtt, Noël P
36Charpentier, Guillaume
37Chines, Peter S
38Cornelis, Marilyn
39Couper, David J
40Crawford, Gabe
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42Elliott, Katherine S
43Elliott, Amanda L
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55Hassanali, Neelam
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64Kraft, Peter
65Kuusisto, Johanna
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67Li, Man
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75Narisu, Narisu
76Nilsson, Peter
77Owen, Katharine R
78Payne, Felicity
79Perry, John R B
80Petersen, Ann-Kristin
81Platou, Carl
82Proença, Christine
83Prokopenko, Inga
84Rathmann, Wolfgang
85Rayner, N William
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92Shrader, Peter
93Sigurdsson, Gunnar
94Sparsø, Thomas
95Strassburger, Klaus
96Stringham, Heather M
97Sun, Qi
98Swift, Amy J
99Thorand, Barbara
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titleGenome-wide association study identifies three novel loci for type 2 diabetes.
authorHara, Kazuo ; Fujita, Hayato ; Johnson, Todd A ; Yamauchi, Toshimasa ; Yasuda, Kazuki ; Horikoshi, Momoko ; Peng, Chen ; Hu, Cheng ; Ma, Ronald C W ; Imamura, Minako ; Iwata, Minoru ; Tsunoda, Tatsuhiko ; Morizono, Takashi ; Shojima, Nobuhiro ; So, Wing Yee ; Leung, Ting Fan ; Kwan, Patrick ; Zhang,...
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1Genetic Loci–Genetics
2Genetic Predisposition to Disease–Genetics
3Genetic Variation–Genetics
4Genome, Human–Genetics
5Genome-Wide Association Study–Genetics
6Guanine Nucleotide Dissociation Inhibitors–Genetics
7Haplotypes–Genetics
8Humans–Genetics
9Leptin–Genetics...
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8Ma, Ronald C W
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13Shojima, Nobuhiro
14So, Wing Yee
15Leung, Ting Fan
16Kwan, Patrick
17Zhang, Rong
18Wang, Jie
19Yu, Weihui
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30Chan, Juliana C N
31Teo, Yik Ying
32Shyong, Tai E
33Kamatani, Naoyuki
34Kubo, Michiaki
35Maeda, Shiro
36Kadowaki, Takashi
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39Steinthorsdottir, Valgerdur
40Morris, Andrew P
41Dina, Christian
42Welch, Ryan P
43Zeggini, Eleftheria
44Huth, Cornelia
45Aulchenko, Yurii S
46Thorleifsson, Gudmar
47Mcculloch, Laura J
48Ferreira, Teresa
49Grallert, Harald
50Amin, Najaf
51Wu, Guanming
52Willer, Cristen J
53Raychaudhuri, Soumya
54Mccarroll, Steve A
55Langenberg, Claudia
56Hofmann, Oliver M
57Dupuis, Josée
58Qi, Lu
59Segrè, Ayellet V
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10McCulloch, Laura J
11Ferreira, Teresa
12Grallert, Harald
13Amin, Najaf
14Wu, Guanming
15Willer, Cristen J
16Raychaudhuri, Soumya
17McCarroll, Steve A
18Langenberg, Claudia
19Hofmann, Oliver M
20Dupuis, Josée
21Qi, Lu
22Segrè, Ayellet V
23van Hoek, Mandy
24Navarro, Pau
25Ardlie, Kristin
26Balkau, Beverley
27Benediktsson, Rafn
28Bennett, Amanda J
29Blagieva, Roza
30Boerwinkle, Eric
31Bonnycastle, Lori L
32Bengtsson Boström, Kristina
33Bravenboer, Bert
34Bumpstead, Suzannah
35Burtt, Noël P
36Charpentier, Guillaume
37Chines, Peter S
38Cornelis, Marilyn
39Couper, David J
40Crawford, Gabe
41Doney, Alex S F
42Elliott, Katherine S
43Elliott, Amanda L
44Erdos, Michael R
45Fox, Caroline S
46Franklin, Christopher S
47Ganser, Martha
48Gieger, Christian
49Grarup, Niels
50Green, Todd
51Griffin, Simon
52Groves, Christopher J
53Guiducci, Candace
54Hadjadj, Samy
55Hassanali, Neelam
56Herder, Christian
57Isomaa, Bo
58Jackson, Anne U
59Johnson, Paul R V
60Jørgensen, Torben
61Kao, Wen H L
62Klopp, Norman
63Kong, Augustine
64Kraft, Peter
65Kuusisto, Johanna
66Lauritzen, Torsten
67Li, Man
68Lieverse, Aloysius
69Lindgren, Cecilia M
70Lyssenko, Valeriya
71Marre, Michel
72Meitinger, Thomas
73Midthjell, Kristian
74Morken, Mario A
75Narisu, Narisu
76Nilsson, Peter
77Owen, Katharine R
78Payne, Felicity
79Perry, John R B
80Petersen, Ann-Kristin
81Platou, Carl
82Proença, Christine
83Prokopenko, Inga
84Rathmann, Wolfgang
85Rayner, N William
86Robertson, Neil R
87Rocheleau, Ghislain
88Roden, Michael
89Sampson, Michael J
90Saxena, Richa
91Shields, Beverley M
92Shrader, Peter
93Sigurdsson, Gunnar
94Sparsø, Thomas
95Strassburger, Klaus
96Stringham, Heather M
97Sun, Qi
98Swift, Amy J
99Thorand, Barbara
100...
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