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De novo generation of singlet oxygen and ammine ligands by photoactivation of a platinum anticancer complex.

Worth the excitement: Highly reactive oxygen and nitrogen species are generated by photoactivation of the anticancer platinum(IV) complex trans,trans,trans-[Pt(N sub(3)) sub(2)(OH) sub(2)(MA)(Py)] (MA=methylamine, Py=pyridine). Singlet oxygen is formed from the hydroxido ligands and not from dissolv... Full description

Journal Title: Angewandte Chemie (International ed. in English) December 16, 2013, Vol.52(51), pp.13633-13637
Main Author: Zhao, Yao
Other Authors: Farrer, Nicola J , Li, Huilin , Butler, Jennifer S , Mcquitty, Ruth J , Habtemariam, Abraha , Wang, Fuyi , Sadler, Peter J
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1521-3773 ; DOI: 1521-3773 ; DOI: 10.1002/anie.201307505
Link: http://search.proquest.com/docview/1469639026/?pq-origsite=primo
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recordid: proquest1469639026
title: De novo generation of singlet oxygen and ammine ligands by photoactivation of a platinum anticancer complex.
format: Article
creator:
  • Zhao, Yao
  • Farrer, Nicola J
  • Li, Huilin
  • Butler, Jennifer S
  • Mcquitty, Ruth J
  • Habtemariam, Abraha
  • Wang, Fuyi
  • Sadler, Peter J
subjects:
  • Antineoplastic Agents–Pharmacology
  • Guanine–Chemistry
  • Ligands–Chemistry
  • Oxidation-Reduction–Chemistry
  • Platinum–Chemistry
  • Singlet Oxygen–Chemistry
  • Antineoplastic Agents
  • Ligands
  • Singlet Oxygen
  • Platinum
  • Guanine
  • Antitumor Agents
  • Bioinorganic Chemistry
  • Guanine Oxidation
  • Photoactivation
  • Singlet Oxygen
ispartof: Angewandte Chemie (International ed. in English), December 16, 2013, Vol.52(51), pp.13633-13637
description: Worth the excitement: Highly reactive oxygen and nitrogen species are generated by photoactivation of the anticancer platinum(IV) complex trans,trans,trans-[Pt(N sub(3)) sub(2)(OH) sub(2)(MA)(Py)] (MA=methylamine, Py=pyridine). Singlet oxygen is formed from the hydroxido ligands and not from dissolved oxygen, and ammine ligands are products from the conversion of azido ligands to nitrenes. Both processes can induce oxidation of guanine.
language: eng
source:
identifier: E-ISSN: 1521-3773 ; DOI: 1521-3773 ; DOI: 10.1002/anie.201307505
fulltext: fulltext
issn:
  • 15213773
  • 1521-3773
url: Link


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titleDe novo generation of singlet oxygen and ammine ligands by photoactivation of a platinum anticancer complex.
creatorZhao, Yao ; Farrer, Nicola J ; Li, Huilin ; Butler, Jennifer S ; Mcquitty, Ruth J ; Habtemariam, Abraha ; Wang, Fuyi ; Sadler, Peter J
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subjectAntineoplastic Agents–Pharmacology ; Guanine–Chemistry ; Ligands–Chemistry ; Oxidation-Reduction–Chemistry ; Platinum–Chemistry ; Singlet Oxygen–Chemistry ; Antineoplastic Agents ; Ligands ; Singlet Oxygen ; Platinum ; Guanine ; Antitumor Agents ; Bioinorganic Chemistry ; Guanine Oxidation ; Photoactivation ; Singlet Oxygen
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descriptionWorth the excitement: Highly reactive oxygen and nitrogen species are generated by photoactivation of the anticancer platinum(IV) complex trans,trans,trans-[Pt(N sub(3)) sub(2)(OH) sub(2)(MA)(Py)] (MA=methylamine, Py=pyridine). Singlet oxygen is formed from the hydroxido ligands and not from dissolved oxygen, and ammine ligands are products from the conversion of azido ligands to nitrenes. Both processes can induce oxidation of guanine.
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titleDe novo generation of singlet oxygen and ammine ligands by photoactivation of a platinum anticancer complex.
authorZhao, Yao ; Farrer, Nicola J ; Li, Huilin ; Butler, Jennifer S ; Mcquitty, Ruth J ; Habtemariam, Abraha ; Wang, Fuyi ; Sadler, Peter J
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