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In vivo Administration of [beta]2-agonist Clenbuterol and Subsequent Increase in Skeletal Muscle Mass in Neonatal Chicks

  In this study, the effect of β2-agonist clenbuterol administration was investigated in chicks (Gallus gallus domesticus) at 6 days of age. Chicks were given single subcutaneous administration of clenbuterol dissolved in saline at a concentration of 1 mg/kg body weight. Twenty-four hours after clen... Full description

Journal Title: The Journal of Poultry Science 2013, Vol.50(2), p.150
Main Author: Ijiri, Daichi
Other Authors: Ishitani, Kanae , Matsubara, Tomoko , Hirabayashi, Miho , Kanai, Yukio , Ohtsuka, Akira
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 13467395 ; E-ISSN: 13490486
Link: http://search.proquest.com/docview/1478034562/?pq-origsite=primo
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title: In vivo Administration of [beta]2-agonist Clenbuterol and Subsequent Increase in Skeletal Muscle Mass in Neonatal Chicks
format: Article
creator:
  • Ijiri, Daichi
  • Ishitani, Kanae
  • Matsubara, Tomoko
  • Hirabayashi, Miho
  • Kanai, Yukio
  • Ohtsuka, Akira
subjects:
  • Atrogin-1/Mafbx
  • Β2-Adrenergic Agonist
  • Neonatal Chicks
  • Skeletal Muscle Growth
ispartof: The Journal of Poultry Science, 2013, Vol.50(2), p.150
description:   In this study, the effect of β2-agonist clenbuterol administration was investigated in chicks (Gallus gallus domesticus) at 6 days of age. Chicks were given single subcutaneous administration of clenbuterol dissolved in saline at a concentration of 1 mg/kg body weight. Twenty-four hours after clenbuterol administration, the ratio of skeletal muscle weight to body weight was increased in chicks treated with clenbuterol, while their body and heart weight were not affected. Although expressions of IGF-I and myostatin mRNA were not changed, the expression of atrogin-1/MAFbx mRNA was significantly decreased by clenbuterol administration. This observation suggested that administration of clenbuterol to neonatal chicks might increase the proportion of muscle mass to body mass. And the decreased expression of atrogin-1/MAFbx might be involved in the growth of skeletal muscle of chicks treated with clenbuterol.
language: eng
source:
identifier: ISSN: 13467395 ; E-ISSN: 13490486
fulltext: fulltext
issn:
  • 13467395
  • 1346-7395
  • 13490486
  • 1349-0486
url: Link


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titleIn vivo Administration of [beta]2-agonist Clenbuterol and Subsequent Increase in Skeletal Muscle Mass in Neonatal Chicks
creatorIjiri, Daichi ; Ishitani, Kanae ; Matsubara, Tomoko ; Hirabayashi, Miho ; Kanai, Yukio ; Ohtsuka, Akira
ispartofThe Journal of Poultry Science, 2013, Vol.50(2), p.150
identifierISSN: 13467395 ; E-ISSN: 13490486
description  In this study, the effect of β2-agonist clenbuterol administration was investigated in chicks (Gallus gallus domesticus) at 6 days of age. Chicks were given single subcutaneous administration of clenbuterol dissolved in saline at a concentration of 1 mg/kg body weight. Twenty-four hours after clenbuterol administration, the ratio of skeletal muscle weight to body weight was increased in chicks treated with clenbuterol, while their body and heart weight were not affected. Although expressions of IGF-I and myostatin mRNA were not changed, the expression of atrogin-1/MAFbx mRNA was significantly decreased by clenbuterol administration. This observation suggested that administration of clenbuterol to neonatal chicks might increase the proportion of muscle mass to body mass. And the decreased expression of atrogin-1/MAFbx might be involved in the growth of skeletal muscle of chicks treated with clenbuterol.
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titleIn vivo Administration of [beta]2-agonist Clenbuterol and Subsequent Increase in Skeletal Muscle Mass in Neonatal Chicks
description  In this study, the effect of β2-agonist clenbuterol administration was investigated in chicks (Gallus gallus domesticus) at 6 days of age. Chicks were given single subcutaneous administration of clenbuterol dissolved in saline at a concentration of 1 mg/kg body weight. Twenty-four hours after clenbuterol administration, the ratio of skeletal muscle weight to body weight was increased in chicks treated with clenbuterol, while their body and heart weight were not affected. Although expressions of IGF-I and myostatin mRNA were not changed, the expression of atrogin-1/MAFbx mRNA was significantly decreased by clenbuterol administration. This observation suggested that administration of clenbuterol to neonatal chicks might increase the proportion of muscle mass to body mass. And the decreased expression of atrogin-1/MAFbx might be involved in the growth of skeletal muscle of chicks treated with clenbuterol.
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abstract  In this study, the effect of β2-agonist clenbuterol administration was investigated in chicks (Gallus gallus domesticus) at 6 days of age. Chicks were given single subcutaneous administration of clenbuterol dissolved in saline at a concentration of 1 mg/kg body weight. Twenty-four hours after clenbuterol administration, the ratio of skeletal muscle weight to body weight was increased in chicks treated with clenbuterol, while their body and heart weight were not affected. Although expressions of IGF-I and myostatin mRNA were not changed, the expression of atrogin-1/MAFbx mRNA was significantly decreased by clenbuterol administration. This observation suggested that administration of clenbuterol to neonatal chicks might increase the proportion of muscle mass to body mass. And the decreased expression of atrogin-1/MAFbx might be involved in the growth of skeletal muscle of chicks treated with clenbuterol.
copIbaraki
pubJapan Science and Technology Agency
urlhttp://search.proquest.com/docview/1478034562/
doi10.2141/jpsa.0120120
pages150-154