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Contribution of NKX2-3 polymorphisms to inflammatory bowel diseases: a meta-analysis of 35358 subjects.

Polymorphisms in NKX2-3 gene have been inconsistently associated with Crohn's disease (CD) and ulcerative colitis (UC). To generate large-scale evidence on whether NKX2-3 polymorphisms are associated with CD or UC susceptibility we have conducted a meta-analysis of 17 studies involving 17329 patient... Full description

Journal Title: Scientific reports January 29, 2014, Vol.4, p.3924
Main Author: Lu, Xiaocheng
Other Authors: Tang, Linjun , Li, Kai , Zheng, Jinyu , Zhao, Penglai , Tao, Yi , Li, Li-Xin
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 2045-2322 ; DOI: 10.1038/srep03924
Link: http://search.proquest.com/docview/1492714394/?pq-origsite=primo
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title: Contribution of NKX2-3 polymorphisms to inflammatory bowel diseases: a meta-analysis of 35358 subjects.
format: Article
creator:
  • Lu, Xiaocheng
  • Tang, Linjun
  • Li, Kai
  • Zheng, Jinyu
  • Zhao, Penglai
  • Tao, Yi
  • Li, Li-Xin
subjects:
  • Adolescent–Genetics
  • Adult–Genetics
  • Aged–Genetics
  • Alleles–Genetics
  • Asian Continental Ancestry Group–Genetics
  • Case-Control Studies–Genetics
  • Child–Genetics
  • Child, Preschool–Genetics
  • European Continental Ancestry Group–Genetics
  • Female–Genetics
  • Genetic Predisposition to Disease–Genetics
  • Genotype–Genetics
  • Homeodomain Proteins–Genetics
  • Humans–Genetics
  • Inflammatory Bowel Diseases–Genetics
  • Male–Genetics
  • Middle Aged–Genetics
  • Polymorphism, Genetic–Genetics
  • Risk Factors–Genetics
  • Transcription Factors
ispartof: Scientific reports, January 29, 2014, Vol.4, p.3924
description: Polymorphisms in NKX2-3 gene have been inconsistently associated with Crohn's disease (CD) and ulcerative colitis (UC). To generate large-scale evidence on whether NKX2-3 polymorphisms are associated with CD or UC susceptibility we have conducted a meta-analysis of 17 studies involving 17329 patients and 18029 controls. A significantly increased CD or UC risk was observed in persons carrying a G allele at rs10883365 polymorphism (A/G) compared with those with a A allele. (OR = 1.226, 95%CI: 1.177-1.277 and OR = 1.274, 95%CI: 1.175-1.382 respectively). In the subgroup analysis, a significantly increased CD risk was found in both Europeans and Asians. For rs11190140 polymorphism (C/T) and CD risk, the risk estimate for the allele contrast was OR = 1.201 (1.136-1.269). This meta-analysis provided a robust result that persons with a G or T allele may have a moderately increased risk of CD, and suggested that rs10883365 polymorphism was also a candidate gene polymorphism for UC susceptibility....
language: eng
source:
identifier: E-ISSN: 2045-2322 ; DOI: 10.1038/srep03924
fulltext: fulltext
issn:
  • 20452322
  • 2045-2322
url: Link


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titleContribution of NKX2-3 polymorphisms to inflammatory bowel diseases: a meta-analysis of 35358 subjects.
creatorLu, Xiaocheng ; Tang, Linjun ; Li, Kai ; Zheng, Jinyu ; Zhao, Penglai ; Tao, Yi ; Li, Li-Xin
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ispartofScientific reports, January 29, 2014, Vol.4, p.3924
identifierE-ISSN: 2045-2322 ; DOI: 10.1038/srep03924
subjectAdolescent–Genetics ; Adult–Genetics ; Aged–Genetics ; Alleles–Genetics ; Asian Continental Ancestry Group–Genetics ; Case-Control Studies–Genetics ; Child–Genetics ; Child, Preschool–Genetics ; European Continental Ancestry Group–Genetics ; Female–Genetics ; Genetic Predisposition to Disease–Genetics ; Genotype–Genetics ; Homeodomain Proteins–Genetics ; Humans–Genetics ; Inflammatory Bowel Diseases–Genetics ; Male–Genetics ; Middle Aged–Genetics ; Polymorphism, Genetic–Genetics ; Risk Factors–Genetics ; Transcription Factors
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descriptionPolymorphisms in NKX2-3 gene have been inconsistently associated with Crohn's disease (CD) and ulcerative colitis (UC). To generate large-scale evidence on whether NKX2-3 polymorphisms are associated with CD or UC susceptibility we have conducted a meta-analysis of 17 studies involving 17329 patients and 18029 controls. A significantly increased CD or UC risk was observed in persons carrying a G allele at rs10883365 polymorphism (A/G) compared with those with a A allele. (OR = 1.226, 95%CI: 1.177-1.277 and OR = 1.274, 95%CI: 1.175-1.382 respectively). In the subgroup analysis, a significantly increased CD risk was found in both Europeans and Asians. For rs11190140 polymorphism (C/T) and CD risk, the risk estimate for the allele contrast was OR = 1.201 (1.136-1.269). This meta-analysis provided a robust result that persons with a G or T allele may have a moderately increased risk of CD, and suggested that rs10883365 polymorphism was also a candidate gene polymorphism for UC susceptibility....
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