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Highly effective generic adjuvant systems for orphan or poverty-related vaccines

Safe and effective adjuvants are needed for many vaccines with limited commercial appeal, such as vaccines to infrequent (orphan) diseases or to neglected and poverty-related diseases. Here we found that three nonproprietary liposome formulations containing monophosphoryl lipid A each induced 3-fold... Full description

Journal Title: Vaccine Jan 29, 2011, Vol.29(5), pp.873-7
Main Author: Rao, Mangala
Other Authors: Peachman, Kristina , Li, Qin , Matyas, Gary , Shivachandra, Sathish , Borschel, Richard , Morthole, Venee , Fernandez-Prada, Carmen , Alving, Carl , Rao, Venigalla
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0264410X ; E-ISSN: 18732518 ; DOI: 10.1016/j.vaccine.2010.11.049
Link: http://search.proquest.com/docview/1498118398/?pq-origsite=primo
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title: Highly effective generic adjuvant systems for orphan or poverty-related vaccines
format: Article
creator:
  • Rao, Mangala
  • Peachman, Kristina
  • Li, Qin
  • Matyas, Gary
  • Shivachandra, Sathish
  • Borschel, Richard
  • Morthole, Venee
  • Fernandez-Prada, Carmen
  • Alving, Carl
  • Rao, Venigalla
subjects:
  • Adjuvants, Immunologic–Administration & Dosage
  • Adjuvants, Immunologic–Adverse Effects
  • Aluminum Hydroxide–Administration & Dosage
  • Aluminum Hydroxide–Adverse Effects
  • Animals–Prevention & Control
  • Anthrax–Adverse Effects
  • Anthrax Vaccines–Immunology
  • Anthrax Vaccines–Blood
  • Antibodies, Bacterial–Blood
  • Antibodies, Neutralizing–Administration & Dosage
  • Liposomes–Adverse Effects
  • Liposomes–Prevention & Control
  • Macaca Mulatta–Prevention & Control
  • Primate Diseases
ispartof: Vaccine, Jan 29, 2011, Vol.29(5), pp.873-7
description: Safe and effective adjuvants are needed for many vaccines with limited commercial appeal, such as vaccines to infrequent (orphan) diseases or to neglected and poverty-related diseases. Here we found that three nonproprietary liposome formulations containing monophosphoryl lipid A each induced 3-fold to 5-fold increased titers of binding and neutralizing antibodies to anthrax protective antigen compared to aluminum hydroxide-adsorbed antigen in monkeys. All vaccinated monkeys were protected against lethal challenge with aerosolized Ames strain spores.
language: eng
source:
identifier: ISSN: 0264410X ; E-ISSN: 18732518 ; DOI: 10.1016/j.vaccine.2010.11.049
fulltext: fulltext
issn:
  • 0264410X
  • 0264-410X
  • 18732518
  • 1873-2518
url: Link


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descriptionSafe and effective adjuvants are needed for many vaccines with limited commercial appeal, such as vaccines to infrequent (orphan) diseases or to neglected and poverty-related diseases. Here we found that three nonproprietary liposome formulations containing monophosphoryl lipid A each induced 3-fold to 5-fold increased titers of binding and neutralizing antibodies to anthrax protective antigen compared to aluminum hydroxide-adsorbed antigen in monkeys. All vaccinated monkeys were protected against lethal challenge with aerosolized Ames strain spores.
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titleHighly effective generic adjuvant systems for orphan or poverty-related vaccines
authorRao, Mangala ; Peachman, Kristina ; Li, Qin ; Matyas, Gary ; Shivachandra, Sathish ; Borschel, Richard ; Morthole, Venee ; Fernandez-Prada, Carmen ; Alving, Carl ; Rao, Venigalla
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abstractSafe and effective adjuvants are needed for many vaccines with limited commercial appeal, such as vaccines to infrequent (orphan) diseases or to neglected and poverty-related diseases. Here we found that three nonproprietary liposome formulations containing monophosphoryl lipid A each induced 3-fold to 5-fold increased titers of binding and neutralizing antibodies to anthrax protective antigen compared to aluminum hydroxide-adsorbed antigen in monkeys. All vaccinated monkeys were protected against lethal challenge with aerosolized Ames strain spores.
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