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KIR3DL01 recognition of Bw4 ligands in the rhesus macaque: maintenance of Bw4 specificity since the divergence of apes and Old World monkeys.

The identification of MHC class I ligands for rhesus macaque killer cell Ig-like receptors (KIRs) is fundamental to our basic understanding of KIR and MHC class I coevolution and to the study of NK cell responses in this nonhuman primate model for AIDS and other viral diseases. In this study, we sho... Full description

Journal Title: Journal of immunology (Baltimore Md. : 1950), February 15, 2014, Vol.192(4), pp.1907-1917
Main Author: Schafer, Jamie L
Other Authors: Colantonio, Arnaud D , Neidermyer, William J , Dudley, Dawn M , Connole, Michelle , O'Connor, David H , Evans, David T
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1550-6606 ; DOI: 1550-6606 ; DOI: 10.4049/jimmunol.1302883
Link: http://search.proquest.com/docview/1499137370/?pq-origsite=primo
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title: KIR3DL01 recognition of Bw4 ligands in the rhesus macaque: maintenance of Bw4 specificity since the divergence of apes and Old World monkeys.
format: Article
creator:
  • Schafer, Jamie L
  • Colantonio, Arnaud D
  • Neidermyer, William J
  • Dudley, Dawn M
  • Connole, Michelle
  • O'Connor, David H
  • Evans, David T
subjects:
  • Amino Acid Sequence–Immunology
  • Animals–Metabolism
  • Cell Line–Immunology
  • Epitopes, T-Lymphocyte–Immunology
  • HLA-B Antigens–Metabolism
  • Histocompatibility Antigens Class I–Immunology
  • Humans–Metabolism
  • Jurkat Cells–Genetics
  • Killer Cells, Natural–Immunology
  • Ligands–Immunology
  • Macaca Mulatta–Genetics
  • Molecular Sequence Data–Immunology
  • Protein Binding–Immunology
  • Protein Structure, Tertiary–Immunology
  • Receptors, Kir–Immunology
  • Abridged
  • Epitopes, T-Lymphocyte
  • HLA-B Antigens
  • HLA-Bw4 Antigen
  • Histocompatibility Antigens Class I
  • Ligands
  • Receptors, Kir
ispartof: Journal of immunology (Baltimore, Md. : 1950), February 15, 2014, Vol.192(4), pp.1907-1917
description: The identification of MHC class I ligands for rhesus macaque killer cell Ig-like receptors (KIRs) is fundamental to our basic understanding of KIR and MHC class I coevolution and to the study of NK cell responses in this nonhuman primate model for AIDS and other viral diseases. In this study, we show that Mamu-KIR3DL01, which is expressed by ∼90% of rhesus macaques, recognizes MHC class I molecules with a Bw4 motif. Primary NK cells expressing Mamu-KIR3DL01 were identified by staining with a mAb which, in this study, was shown to bind Mamu-KIR3DL01 allotypes with an aspartic acid at position 233. The cytolytic activity of Mamu-KIR3DL01(+) NK cells was suppressed by cell lines expressing the Bw4 molecules Mamu-B*007:01, -B*041:01, -B*058:02, and -B*065:01. The Bw4 motif was necessary for Mamu-KIR3DL01 recognition because substitutions in this region abrogated Mamu-KIR3DL01(+) NK cell inhibition. However, the presence of a Bw4 motif was not sufficient for recognition because another Bw4 molecule, Mamu-B*017:01, failed to suppress the cytolytic activity of these NK cells. Replacement of three residues in Mamu-B*017:01, predicted to be KIR contacts based on the three-dimensional structure of the human KIR3DL1-HLA-Bw4 complex, with the corresponding residues at these positions for the other Mamu-Bw4 ligands restored Mamu-KIR3DL01(+) NK cell inhibition. These results define the ligand specificity of one of the most polymorphic and commonly expressed KIRs in the rhesus macaque and reveal similarities in Bw4 recognition by Mamu-KIR3DL01 and human KIR3DL1, despite the absence of an orthologous relationship between these two KIRs or conservation of surface residues predicted to interact with MHC class I ligands.
language: eng
source:
identifier: E-ISSN: 1550-6606 ; DOI: 1550-6606 ; DOI: 10.4049/jimmunol.1302883
fulltext: fulltext
issn:
  • 15506606
  • 1550-6606
url: Link


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titleKIR3DL01 recognition of Bw4 ligands in the rhesus macaque: maintenance of Bw4 specificity since the divergence of apes and Old World monkeys.
creatorSchafer, Jamie L ; Colantonio, Arnaud D ; Neidermyer, William J ; Dudley, Dawn M ; Connole, Michelle ; O'Connor, David H ; Evans, David T
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subjectAmino Acid Sequence–Immunology ; Animals–Metabolism ; Cell Line–Immunology ; Epitopes, T-Lymphocyte–Immunology ; HLA-B Antigens–Metabolism ; Histocompatibility Antigens Class I–Immunology ; Humans–Metabolism ; Jurkat Cells–Genetics ; Killer Cells, Natural–Immunology ; Ligands–Immunology ; Macaca Mulatta–Genetics ; Molecular Sequence Data–Immunology ; Protein Binding–Immunology ; Protein Structure, Tertiary–Immunology ; Receptors, Kir–Immunology ; Abridged ; Epitopes, T-Lymphocyte ; HLA-B Antigens ; HLA-Bw4 Antigen ; Histocompatibility Antigens Class I ; Ligands ; Receptors, Kir
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descriptionThe identification of MHC class I ligands for rhesus macaque killer cell Ig-like receptors (KIRs) is fundamental to our basic understanding of KIR and MHC class I coevolution and to the study of NK cell responses in this nonhuman primate model for AIDS and other viral diseases. In this study, we show that Mamu-KIR3DL01, which is expressed by ∼90% of rhesus macaques, recognizes MHC class I molecules with a Bw4 motif. Primary NK cells expressing Mamu-KIR3DL01 were identified by staining with a mAb which, in this study, was shown to bind Mamu-KIR3DL01 allotypes with an aspartic acid at position 233. The cytolytic activity of Mamu-KIR3DL01(+) NK cells was suppressed by cell lines expressing the Bw4 molecules Mamu-B*007:01, -B*041:01, -B*058:02, and -B*065:01. The Bw4 motif was necessary for Mamu-KIR3DL01 recognition because substitutions in this region abrogated Mamu-KIR3DL01(+) NK cell inhibition. However, the presence of a Bw4 motif was not sufficient for recognition because another Bw4 molecule, Mamu-B*017:01, failed to suppress the cytolytic activity of these NK cells. Replacement of three residues in Mamu-B*017:01, predicted to be KIR contacts based on the three-dimensional structure of the human KIR3DL1-HLA-Bw4 complex, with the corresponding residues at these positions for the other Mamu-Bw4 ligands restored Mamu-KIR3DL01(+) NK cell inhibition. These results define the ligand specificity of one of the most polymorphic and commonly expressed KIRs in the rhesus macaque and reveal similarities in Bw4 recognition by Mamu-KIR3DL01 and human KIR3DL1, despite the absence of an orthologous relationship between these two KIRs or conservation of surface residues predicted to interact with MHC class I ligands.
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titleKIR3DL01 recognition of Bw4 ligands in the rhesus macaque: maintenance of Bw4 specificity since the divergence of apes and Old World monkeys.
authorSchafer, Jamie L ; Colantonio, Arnaud D ; Neidermyer, William J ; Dudley, Dawn M ; Connole, Michelle ; O'Connor, David H ; Evans, David T
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date2014-02-15