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Nuclear compartmentalization of odorant receptor genes.

Odorants are detected by odorant receptors, which are located on olfactory sensory neurons of the nose. Each olfactory sensory neuron expresses one single odorant receptor gene allele from a large family of odorant receptor genes. To gain insight into the mechanisms underlying this monogenic and mon... Full description

Journal Title: Proceedings of the National Academy of Sciences of the United States of America February 18, 2014, Vol.111(7), pp.2782-2787
Main Author: Armelin-Correa, Lucia M
Other Authors: Gutiyama, Luciana M , Brandt, Débora Y C , Malnic, Bettina
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1091-6490 ; DOI: 10.1073/pnas.1317036111
Link: http://search.proquest.com/docview/1500685396/?pq-origsite=primo
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title: Nuclear compartmentalization of odorant receptor genes.
format: Article
creator:
  • Armelin-Correa, Lucia M
  • Gutiyama, Luciana M
  • Brandt, Débora Y C
  • Malnic, Bettina
subjects:
  • Alleles–Genetics
  • Animals–Ultrastructure
  • Cell Nucleus–Genetics
  • Chromosomes, Artificial, Bacterial–Metabolism
  • Gene Expression Regulation–Cytology
  • Heterochromatin–Genetics
  • Imaging, Three-Dimensional–Genetics
  • In Situ Hybridization, Fluorescence–Genetics
  • Mice–Genetics
  • Olfactory Receptor Neurons–Genetics
  • Receptors, Odorant–Genetics
  • Heterochromatin
  • Receptors, Odorant
  • H3k27me3
  • OR Gene Choice
  • Chromatin
ispartof: Proceedings of the National Academy of Sciences of the United States of America, February 18, 2014, Vol.111(7), pp.2782-2787
description: Odorants are detected by odorant receptors, which are located on olfactory sensory neurons of the nose. Each olfactory sensory neuron expresses one single odorant receptor gene allele from a large family of odorant receptor genes. To gain insight into the mechanisms underlying this monogenic and monoallelic expression, we examined the 3D nuclear organization of olfactory sensory neurons and determined the positions of homologous odorant receptor gene alleles in relation to different nuclear compartments. Our results show that olfactory neurons exhibit a singular nuclear architecture that is characterized by a large centrally localized constitutive heterochromatin block and by the presence of prominent facultative heterochromatin domains that are localized around this constitutive heterochromatin block. We also found that the two homologous alleles of a given odorant receptor gene are frequently segregated to separate compartments in the nucleus, with one of the alleles localized to the constitutive heterochromatin block and the other one localized to the more plastic facultative heterochromatin, or next to it. Our findings suggest that this nuclear compartmentalization may play a critical role in the expression of odorant receptor genes. H3K27me3 | chromatin | OR gene choice www.pnas.org/cgi/doi/10.1073/pnas.1317036111
language: eng
source:
identifier: E-ISSN: 1091-6490 ; DOI: 10.1073/pnas.1317036111
fulltext: fulltext
issn:
  • 10916490
  • 1091-6490
url: Link


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titleNuclear compartmentalization of odorant receptor genes.
creatorArmelin-Correa, Lucia M ; Gutiyama, Luciana M ; Brandt, Débora Y C ; Malnic, Bettina
contributorArmelin-Correa, Lucia M (correspondence author) ; Armelin-Correa, Lucia M (record owner)
ispartofProceedings of the National Academy of Sciences of the United States of America, February 18, 2014, Vol.111(7), pp.2782-2787
identifierE-ISSN: 1091-6490 ; DOI: 10.1073/pnas.1317036111
subjectAlleles–Genetics ; Animals–Ultrastructure ; Cell Nucleus–Genetics ; Chromosomes, Artificial, Bacterial–Metabolism ; Gene Expression Regulation–Cytology ; Heterochromatin–Genetics ; Imaging, Three-Dimensional–Genetics ; In Situ Hybridization, Fluorescence–Genetics ; Mice–Genetics ; Olfactory Receptor Neurons–Genetics ; Receptors, Odorant–Genetics ; Heterochromatin ; Receptors, Odorant ; H3k27me3 ; OR Gene Choice ; Chromatin
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descriptionOdorants are detected by odorant receptors, which are located on olfactory sensory neurons of the nose. Each olfactory sensory neuron expresses one single odorant receptor gene allele from a large family of odorant receptor genes. To gain insight into the mechanisms underlying this monogenic and monoallelic expression, we examined the 3D nuclear organization of olfactory sensory neurons and determined the positions of homologous odorant receptor gene alleles in relation to different nuclear compartments. Our results show that olfactory neurons exhibit a singular nuclear architecture that is characterized by a large centrally localized constitutive heterochromatin block and by the presence of prominent facultative heterochromatin domains that are localized around this constitutive heterochromatin block. We also found that the two homologous alleles of a given odorant receptor gene are frequently segregated to separate compartments in the nucleus, with one of the alleles localized to the constitutive heterochromatin block and the other one localized to the more plastic facultative heterochromatin, or next to it. Our findings suggest that this nuclear compartmentalization may play a critical role in the expression of odorant receptor genes. H3K27me3 | chromatin | OR gene choice www.pnas.org/cgi/doi/10.1073/pnas.1317036111
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