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Near-Infrared Light-Sensitive Liposomes for the Enhanced Photothermal Tumor Treatment by the Combination with Chemotherapy

To develop a near-infrared (NIR) light-sensitive liposome, which contains hollow gold nanospheres (HAuNS) and doxorubicin (DOX), and evaluate their potential utility for enhancing antitumor activity and controlling drug release. The liposomes (DOX&HAuNS-TSL) were designed based on a thermal sensitiv... Full description

Journal Title: Pharmaceutical Research Mar 2014, Vol.31(3), pp.554-65
Main Author: You, Jian
Other Authors: Zhang, Peizun , Hu, Fuqiang , Du, Yongzhong , Yuan, Hong , Zhu, Jiang , Wang, Zuhua , Zhou, Jialin , Li, Chun
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 07248741 ; E-ISSN: 1573904X ; DOI: 10.1007/s11095-013-1180-7
Link: http://search.proquest.com/docview/1500913804/?pq-origsite=primo
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title: Near-Infrared Light-Sensitive Liposomes for the Enhanced Photothermal Tumor Treatment by the Combination with Chemotherapy
format: Article
creator:
  • You, Jian
  • Zhang, Peizun
  • Hu, Fuqiang
  • Du, Yongzhong
  • Yuan, Hong
  • Zhu, Jiang
  • Wang, Zuhua
  • Zhou, Jialin
  • Li, Chun
subjects:
  • Animals–Administration & Dosage
  • Antibiotics, Antineoplastic–Pharmacokinetics
  • Antibiotics, Antineoplastic–Therapeutic Use
  • Antibiotics, Antineoplastic–Chemistry
  • Cell Line, Tumor–Administration & Dosage
  • Delayed-Action Preparations–Analogs & Derivatives
  • Doxorubicin–Pharmacokinetics
  • Doxorubicin–Therapeutic Use
  • Doxorubicin–Chemistry
  • Doxorubicin–Chemistry
  • Gold–Ultrastructure
  • Humans–Chemistry
  • Hyperthermia, Induced–Ultrastructure
  • Infrared Rays–Pathology
  • Light–Therapy
  • Liposomes–Administration & Dosage
ispartof: Pharmaceutical Research, Mar 2014, Vol.31(3), pp.554-65
description: To develop a near-infrared (NIR) light-sensitive liposome, which contains hollow gold nanospheres (HAuNS) and doxorubicin (DOX), and evaluate their potential utility for enhancing antitumor activity and controlling drug release. The liposomes (DOX&HAuNS-TSL) were designed based on a thermal sensitive liposome (TSL) formulation, and hydrophobically modified HAuNS were attached onto the membrane of the liposomes. The behavior of DOX release from the liposomes was investigated by the dialysis, diffusion in agarose gel and cellular uptake of the drug. The biodistribution of DOX&HAuNS-TSL was assessed by i.v. injection in tumor-bearing nude mice. Antitumor efficacy was evaluated both histologically using excised tissue and intuitively by measuring the tumor size and weight. Rapid and repetitive DOX release from the liposomes (DOX&HAuNS-TSL), could be readily achieved upon NIR laser irradiation. The treatment of tumor cells with DOX&HAuNS-TSL followed by NIR laser irradiation showed significantly...
language: eng
source:
identifier: ISSN: 07248741 ; E-ISSN: 1573904X ; DOI: 10.1007/s11095-013-1180-7
fulltext: fulltext
issn:
  • 07248741
  • 0724-8741
  • 1573904X
  • 1573-904X
url: Link


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titleNear-Infrared Light-Sensitive Liposomes for the Enhanced Photothermal Tumor Treatment by the Combination with Chemotherapy
creatorYou, Jian ; Zhang, Peizun ; Hu, Fuqiang ; Du, Yongzhong ; Yuan, Hong ; Zhu, Jiang ; Wang, Zuhua ; Zhou, Jialin ; Li, Chun
ispartofPharmaceutical Research, Mar 2014, Vol.31(3), pp.554-65
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subjectAnimals–Administration & Dosage ; Antibiotics, Antineoplastic–Pharmacokinetics ; Antibiotics, Antineoplastic–Therapeutic Use ; Antibiotics, Antineoplastic–Chemistry ; Cell Line, Tumor–Administration & Dosage ; Delayed-Action Preparations–Analogs & Derivatives ; Doxorubicin–Pharmacokinetics ; Doxorubicin–Therapeutic Use ; Doxorubicin–Chemistry ; Doxorubicin–Chemistry ; Gold–Ultrastructure ; Humans–Chemistry ; Hyperthermia, Induced–Ultrastructure ; Infrared Rays–Pathology ; Light–Therapy ; Liposomes–Administration & Dosage
descriptionTo develop a near-infrared (NIR) light-sensitive liposome, which contains hollow gold nanospheres (HAuNS) and doxorubicin (DOX), and evaluate their potential utility for enhancing antitumor activity and controlling drug release. The liposomes (DOX&HAuNS-TSL) were designed based on a thermal sensitive liposome (TSL) formulation, and hydrophobically modified HAuNS were attached onto the membrane of the liposomes. The behavior of DOX release from the liposomes was investigated by the dialysis, diffusion in agarose gel and cellular uptake of the drug. The biodistribution of DOX&HAuNS-TSL was assessed by i.v. injection in tumor-bearing nude mice. Antitumor efficacy was evaluated both histologically using excised tissue and intuitively by measuring the tumor size and weight. Rapid and repetitive DOX release from the liposomes (DOX&HAuNS-TSL), could be readily achieved upon NIR laser irradiation. The treatment of tumor cells with DOX&HAuNS-TSL followed by NIR laser irradiation showed significantly...
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titleNear-Infrared Light-Sensitive Liposomes for the Enhanced Photothermal Tumor Treatment by the Combination with Chemotherapy
descriptionTo develop a near-infrared (NIR) light-sensitive liposome, which contains hollow gold nanospheres (HAuNS) and doxorubicin (DOX), and evaluate their potential utility for enhancing antitumor activity and controlling drug release. The liposomes (DOX&HAuNS-TSL) were designed based on a thermal sensitive liposome (TSL) formulation, and hydrophobically modified HAuNS were attached onto the membrane of the liposomes. The behavior of DOX release from the liposomes was investigated by the dialysis, diffusion in agarose gel and cellular uptake of the drug. The biodistribution of DOX&HAuNS-TSL was assessed by i.v. injection in tumor-bearing nude mice. Antitumor efficacy was evaluated both histologically using excised tissue and intuitively by measuring the tumor size and weight. Rapid and repetitive DOX release from the liposomes (DOX&HAuNS-TSL), could be readily achieved upon NIR laser irradiation. The treatment of tumor cells with DOX&HAuNS-TSL followed by NIR laser irradiation showed significantly...
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titleNear-Infrared Light-Sensitive Liposomes for the Enhanced Photothermal Tumor Treatment by the Combination with Chemotherapy
authorYou, Jian ; Zhang, Peizun ; Hu, Fuqiang ; Du, Yongzhong ; Yuan, Hong ; Zhu, Jiang ; Wang, Zuhua ; Zhou, Jialin ; Li, Chun
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abstractTo develop a near-infrared (NIR) light-sensitive liposome, which contains hollow gold nanospheres (HAuNS) and doxorubicin (DOX), and evaluate their potential utility for enhancing antitumor activity and controlling drug release. The liposomes (DOX&HAuNS-TSL) were designed based on a thermal sensitive liposome (TSL) formulation, and hydrophobically modified HAuNS were attached onto the membrane of the liposomes. The behavior of DOX release from the liposomes was investigated by the dialysis, diffusion in agarose gel and cellular uptake of the drug. The biodistribution of DOX&HAuNS-TSL was assessed by i.v. injection in tumor-bearing nude mice. Antitumor efficacy was evaluated both histologically using excised tissue and intuitively by measuring the tumor size and weight. Rapid and repetitive DOX release from the liposomes (DOX&HAuNS-TSL), could be readily achieved upon NIR laser irradiation. The treatment of tumor cells with DOX&HAuNS-TSL followed by NIR laser irradiation showed significantly...
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doi10.1007/s11095-013-1180-7
urlhttp://search.proquest.com/docview/1500913804/
date2014-03-01