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Prevention of diabetes with Mediterranean diets: a subgroup analysis of a randomized trial.

BACKGROUNDInterventions promoting weight loss can reduce the incidence of type 2 diabetes mellitus. Whether dietary changes without calorie restriction also protect from diabetes has not been evaluated. OBJECTIVETo assess the efficacy of Mediterranean diets for the primary prevention of diabetes in... Full description

Journal Title: Annals of internal medicine January 7, 2014, Vol.160(1), pp.1-10
Main Author: Salas-Salvadó, Jordi
Other Authors: Bulló, Mònica , Estruch, Ramón , Ros, Emilio , Covas, Maria-Isabel , Ibarrola-Jurado, Núria , Corella, Dolores , Arós, Fernando , Gómez-Gracia, Enrique , Ruiz-Gutiérrez, Valentina , Romaguera, Dora , Lapetra, José , Lamuela-Raventós, Rosa Maria , Serra-Majem, Lluís , Pintó, Xavier , Basora, Josep , Muñoz, Miguel Angel , Sorlí, José V , Martínez-González, Miguel A
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1539-3704 ; DOI: 1539-3704 ; DOI: 10.7326/M13-1725
Link: http://search.proquest.com/docview/1503548434/?pq-origsite=primo
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title: Prevention of diabetes with Mediterranean diets: a subgroup analysis of a randomized trial.
format: Article
creator:
  • Salas-Salvadó, Jordi
  • Bulló, Mònica
  • Estruch, Ramón
  • Ros, Emilio
  • Covas, Maria-Isabel
  • Ibarrola-Jurado, Núria
  • Corella, Dolores
  • Arós, Fernando
  • Gómez-Gracia, Enrique
  • Ruiz-Gutiérrez, Valentina
  • Romaguera, Dora
  • Lapetra, José
  • Lamuela-Raventós, Rosa Maria
  • Serra-Majem, Lluís
  • Pintó, Xavier
  • Basora, Josep
  • Muñoz, Miguel Angel
  • Sorlí, José V
  • Martínez-González, Miguel A
subjects:
  • Aged–Epidemiology
  • Aged, 80 and Over–Prevention & Control
  • Cardiovascular Diseases–Epidemiology
  • Diabetes Mellitus, Type 2–Epidemiology
  • Diet, Fat-Restricted–Epidemiology
  • Diet, Mediterranean–Epidemiology
  • Dietary Fats, Unsaturated–Epidemiology
  • Exercise–Epidemiology
  • Female–Epidemiology
  • Humans–Epidemiology
  • Incidence–Epidemiology
  • Male–Epidemiology
  • Middle Aged–Epidemiology
  • Nuts–Epidemiology
  • Olive Oil–Epidemiology
  • Plant Oils–Epidemiology
  • Primary Prevention–Epidemiology
  • Risk Factors–Epidemiology
  • Spain–Epidemiology
  • Weight Loss–Epidemiology
  • Abridged
  • Dietary Fats, Unsaturated
  • Olive Oil
  • Plant Oils
ispartof: Annals of internal medicine, January 7, 2014, Vol.160(1), pp.1-10
description: BACKGROUNDInterventions promoting weight loss can reduce the incidence of type 2 diabetes mellitus. Whether dietary changes without calorie restriction also protect from diabetes has not been evaluated. OBJECTIVETo assess the efficacy of Mediterranean diets for the primary prevention of diabetes in the Prevención con Dieta Mediterránea trial, from October 2003 to December 2010 (median follow-up, 4.1 years). DESIGNSubgroup analysis of a multicenter, randomized trial. (Current Controlled Trials: ISRCTN35739639) SETTING: Primary care centers in Spain. PARTICIPANTSMen and women without diabetes (3541 patients aged 55 to 80 years) at high cardiovascular risk. INTERVENTIONParticipants were randomly assigned and stratified by site, sex, and age but not diabetes status to receive 1 of 3 diets: Mediterranean diet supplemented with extra-virgin olive oil (EVOO), Mediterranean diet supplemented with nuts, or a control diet (advice on a low-fat diet). No intervention to increase physical activity or lose weight was included. MEASUREMENTSIncidence of new-onset type 2 diabetes mellitus (prespecified secondary outcome). RESULTSDuring follow-up, 80, 92, and 101 new-onset cases of diabetes occurred in the Mediterranean diet supplemented with EVOO, Mediterranean diet supplemented with mixed nuts, and control diet groups, respectively, corresponding to rates of 16.0, 18.7, and 23.6 cases per 1000 person-years. Multivariate-adjusted hazard ratios were 0.60 (95% CI, 0.43 to 0.85) for the Mediterranean diet supplemented with EVOO and 0.82 (CI, 0.61 to 1.10) for the Mediterranean diet supplemented with nuts compared with the control diet. LIMITATIONSRandomization was not stratified by diabetes status. Withdrawals were greater in the control group. CONCLUSIONA Mediterranean diet enriched with EVOO but without energy restrictions reduced diabetes risk among persons with high cardiovascular risk. PRIMARY FUNDING SOURCEInstituto de Salud Carlos III.
language: eng
source:
identifier: E-ISSN: 1539-3704 ; DOI: 1539-3704 ; DOI: 10.7326/M13-1725
fulltext: fulltext
issn:
  • 15393704
  • 1539-3704
url: Link


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titlePrevention of diabetes with Mediterranean diets: a subgroup analysis of a randomized trial.
creatorSalas-Salvadó, Jordi ; Bulló, Mònica ; Estruch, Ramón ; Ros, Emilio ; Covas, Maria-Isabel ; Ibarrola-Jurado, Núria ; Corella, Dolores ; Arós, Fernando ; Gómez-Gracia, Enrique ; Ruiz-Gutiérrez, Valentina ; Romaguera, Dora ; Lapetra, José ; Lamuela-Raventós, Rosa Maria ; Serra-Majem, Lluís ; Pintó, Xavier ; Basora, Josep ; Muñoz, Miguel Angel ; Sorlí, José V ; Martínez-González, Miguel A
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ispartofAnnals of internal medicine, January 7, 2014, Vol.160(1), pp.1-10
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subjectAged–Epidemiology ; Aged, 80 and Over–Prevention & Control ; Cardiovascular Diseases–Epidemiology ; Diabetes Mellitus, Type 2–Epidemiology ; Diet, Fat-Restricted–Epidemiology ; Diet, Mediterranean–Epidemiology ; Dietary Fats, Unsaturated–Epidemiology ; Exercise–Epidemiology ; Female–Epidemiology ; Humans–Epidemiology ; Incidence–Epidemiology ; Male–Epidemiology ; Middle Aged–Epidemiology ; Nuts–Epidemiology ; Olive Oil–Epidemiology ; Plant Oils–Epidemiology ; Primary Prevention–Epidemiology ; Risk Factors–Epidemiology ; Spain–Epidemiology ; Weight Loss–Epidemiology ; Abridged ; Dietary Fats, Unsaturated ; Olive Oil ; Plant Oils
descriptionBACKGROUNDInterventions promoting weight loss can reduce the incidence of type 2 diabetes mellitus. Whether dietary changes without calorie restriction also protect from diabetes has not been evaluated. OBJECTIVETo assess the efficacy of Mediterranean diets for the primary prevention of diabetes in the Prevención con Dieta Mediterránea trial, from October 2003 to December 2010 (median follow-up, 4.1 years). DESIGNSubgroup analysis of a multicenter, randomized trial. (Current Controlled Trials: ISRCTN35739639) SETTING: Primary care centers in Spain. PARTICIPANTSMen and women without diabetes (3541 patients aged 55 to 80 years) at high cardiovascular risk. INTERVENTIONParticipants were randomly assigned and stratified by site, sex, and age but not diabetes status to receive 1 of 3 diets: Mediterranean diet supplemented with extra-virgin olive oil (EVOO), Mediterranean diet supplemented with nuts, or a control diet (advice on a low-fat diet). No intervention to increase physical activity or lose weight was included. MEASUREMENTSIncidence of new-onset type 2 diabetes mellitus (prespecified secondary outcome). RESULTSDuring follow-up, 80, 92, and 101 new-onset cases of diabetes occurred in the Mediterranean diet supplemented with EVOO, Mediterranean diet supplemented with mixed nuts, and control diet groups, respectively, corresponding to rates of 16.0, 18.7, and 23.6 cases per 1000 person-years. Multivariate-adjusted hazard ratios were 0.60 (95% CI, 0.43 to 0.85) for the Mediterranean diet supplemented with EVOO and 0.82 (CI, 0.61 to 1.10) for the Mediterranean diet supplemented with nuts compared with the control diet. LIMITATIONSRandomization was not stratified by diabetes status. Withdrawals were greater in the control group. CONCLUSIONA Mediterranean diet enriched with EVOO but without energy restrictions reduced diabetes risk among persons with high cardiovascular risk. PRIMARY FUNDING SOURCEInstituto de Salud Carlos III.
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titlePrevention of diabetes with Mediterranean diets: a subgroup analysis of a randomized trial.
descriptionBACKGROUNDInterventions promoting weight loss can reduce the incidence of type 2 diabetes mellitus. Whether dietary changes without calorie restriction also protect from diabetes has not been evaluated. OBJECTIVETo assess the efficacy of Mediterranean diets for the primary prevention of diabetes in the Prevención con Dieta Mediterránea trial, from October 2003 to December 2010 (median follow-up, 4.1 years). DESIGNSubgroup analysis of a multicenter, randomized trial. (Current Controlled Trials: ISRCTN35739639) SETTING: Primary care centers in Spain. PARTICIPANTSMen and women without diabetes (3541 patients aged 55 to 80 years) at high cardiovascular risk. INTERVENTIONParticipants were randomly assigned and stratified by site, sex, and age but not diabetes status to receive 1 of 3 diets: Mediterranean diet supplemented with extra-virgin olive oil (EVOO), Mediterranean diet supplemented with nuts, or a control diet (advice on a low-fat diet). No intervention to increase physical activity or lose weight was included. MEASUREMENTSIncidence of new-onset type 2 diabetes mellitus (prespecified secondary outcome). RESULTSDuring follow-up, 80, 92, and 101 new-onset cases of diabetes occurred in the Mediterranean diet supplemented with EVOO, Mediterranean diet supplemented with mixed nuts, and control diet groups, respectively, corresponding to rates of 16.0, 18.7, and 23.6 cases per 1000 person-years. Multivariate-adjusted hazard ratios were 0.60 (95% CI, 0.43 to 0.85) for the Mediterranean diet supplemented with EVOO and 0.82 (CI, 0.61 to 1.10) for the Mediterranean diet supplemented with nuts compared with the control diet. LIMITATIONSRandomization was not stratified by diabetes status. Withdrawals were greater in the control group. CONCLUSIONA Mediterranean diet enriched with EVOO but without energy restrictions reduced diabetes risk among persons with high cardiovascular risk. PRIMARY FUNDING SOURCEInstituto de Salud Carlos III.
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1Aged, 80 and Over–Prevention & Control
2Cardiovascular Diseases–Epidemiology
3Diabetes Mellitus, Type 2–Epidemiology
4Diet, Fat-Restricted–Epidemiology
5Diet, Mediterranean–Epidemiology
6Dietary Fats, Unsaturated–Epidemiology
7Exercise–Epidemiology
8Female–Epidemiology
9Humans–Epidemiology
10Incidence–Epidemiology
11Male–Epidemiology
12Middle Aged–Epidemiology
13Nuts–Epidemiology
14Olive Oil–Epidemiology
15Plant Oils–Epidemiology
16Primary Prevention–Epidemiology
17Risk Factors–Epidemiology
18Spain–Epidemiology
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20Abridged
21Dietary Fats, Unsaturated
22Olive Oil
23Plant Oils
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titlePrevention of diabetes with Mediterranean diets: a subgroup analysis of a randomized trial.
authorSalas-Salvadó, Jordi ; Bulló, Mònica ; Estruch, Ramón ; Ros, Emilio ; Covas, Maria-Isabel ; Ibarrola-Jurado, Núria ; Corella, Dolores ; Arós, Fernando ; Gómez-Gracia, Enrique ; Ruiz-Gutiérrez, Valentina ; Romaguera, Dora ; Lapetra, José ; Lamuela-Raventós, Rosa Maria ; Serra-Majem, Lluís ; Pintó, Xavier ; Basora, Josep ; Muñoz, Miguel Angel ; Sorlí, José V ; Martínez-González, Miguel A
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3Diabetes Mellitus, Type 2–Epidemiology
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21Dietary Fats, Unsaturated
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abstractBACKGROUNDInterventions promoting weight loss can reduce the incidence of type 2 diabetes mellitus. Whether dietary changes without calorie restriction also protect from diabetes has not been evaluated. OBJECTIVETo assess the efficacy of Mediterranean diets for the primary prevention of diabetes in the Prevención con Dieta Mediterránea trial, from October 2003 to December 2010 (median follow-up, 4.1 years). DESIGNSubgroup analysis of a multicenter, randomized trial. (Current Controlled Trials: ISRCTN35739639) SETTING: Primary care centers in Spain. PARTICIPANTSMen and women without diabetes (3541 patients aged 55 to 80 years) at high cardiovascular risk. INTERVENTIONParticipants were randomly assigned and stratified by site, sex, and age but not diabetes status to receive 1 of 3 diets: Mediterranean diet supplemented with extra-virgin olive oil (EVOO), Mediterranean diet supplemented with nuts, or a control diet (advice on a low-fat diet). No intervention to increase physical activity or lose weight was included. MEASUREMENTSIncidence of new-onset type 2 diabetes mellitus (prespecified secondary outcome). RESULTSDuring follow-up, 80, 92, and 101 new-onset cases of diabetes occurred in the Mediterranean diet supplemented with EVOO, Mediterranean diet supplemented with mixed nuts, and control diet groups, respectively, corresponding to rates of 16.0, 18.7, and 23.6 cases per 1000 person-years. Multivariate-adjusted hazard ratios were 0.60 (95% CI, 0.43 to 0.85) for the Mediterranean diet supplemented with EVOO and 0.82 (CI, 0.61 to 1.10) for the Mediterranean diet supplemented with nuts compared with the control diet. LIMITATIONSRandomization was not stratified by diabetes status. Withdrawals were greater in the control group. CONCLUSIONA Mediterranean diet enriched with EVOO but without energy restrictions reduced diabetes risk among persons with high cardiovascular risk. PRIMARY FUNDING SOURCEInstituto de Salud Carlos III.
doi10.7326/M13-1725
urlhttp://search.proquest.com/docview/1503548434/
issn00034819
date2014-01-07