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Hemokinin-1(4-11)-induced analgesia selectively up-regulates δ-opioid receptor expression in mice.

Our previous studies have shown that an active fragment of human tachykinins (hHK-1(4-11)) produced an opioid-independent analgesia after intracerebroventricular (i.c.v.) injection in mice, which has been markedly enhanced by a [delta] OR antagonist, naltrindole hydrochloride (NTI). In this study, w... Full description

Journal Title: PloS one 2014, Vol.9(2), p.e90446
Main Author: Fu, Cai-Yun
Other Authors: Xia, Rui-Long , Zhang, Teng-Fei , Lu, Yan , Zhang, Shi-Fu , Yu, Zhi-Qiang , Jin, Tao , Mou, Xiao-Zhou
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0090446
Link: http://search.proquest.com/docview/1504162804/?pq-origsite=primo
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title: Hemokinin-1(4-11)-induced analgesia selectively up-regulates δ-opioid receptor expression in mice.
format: Article
creator:
  • Fu, Cai-Yun
  • Xia, Rui-Long
  • Zhang, Teng-Fei
  • Lu, Yan
  • Zhang, Shi-Fu
  • Yu, Zhi-Qiang
  • Jin, Tao
  • Mou, Xiao-Zhou
subjects:
  • Analgesia–Drug Effects
  • Animals–Administration & Dosage
  • Blotting, Western–Pharmacology
  • Female–Genetics
  • Gene Expression–Metabolism
  • Humans–Genetics
  • Injections, Intraventricular–Metabolism
  • Male–Genetics
  • Mice, Inbred Icr–Metabolism
  • Peptide Fragments–Genetics
  • Pro-Opiomelanocortin–Metabolism
  • Protein Precursors–Administration & Dosage
  • Receptors, Opioid, Delta–Chemistry
  • Receptors, Opioid, Mu–Genetics
  • Reverse Transcriptase Polymerase Chain Reaction–Metabolism
  • Tachykinins–Pharmacology
  • Up-Regulation–Drug Effects
  • Peptide Fragments
  • Protein Precursors
  • Receptors, Opioid, Delta
  • Receptors, Opioid, Mu
  • Tachykinins
  • Hemokinin-1
  • Preprotachykinin
  • Pro-Opiomelanocortin
ispartof: PloS one, 2014, Vol.9(2), p.e90446
description: Our previous studies have shown that an active fragment of human tachykinins (hHK-1(4-11)) produced an opioid-independent analgesia after intracerebroventricular (i.c.v.) injection in mice, which has been markedly enhanced by a [delta] OR antagonist, naltrindole hydrochloride (NTI). In this study, we have further characterized the in vivo analgesia after i.c.v. injection of hHK-1(4-11) in mouse model. Our qRT-PCR results showed that the mRNA levels of several ligands and receptors (e.g. PPT-A, PPT-C, KOR, PDYN and PENK) have not changed significantly. Furthermore, neither transcription nor expression of NK.sub.1 receptor, MOR and POMC have changed noticeably. In contrast, both mRNA and protein levels of DOR have been up-regulated significantly, indicating that the enhanced expression of [delta] opioid receptor negatively modulates the analgesia induced by i.c.v. injection of hHK-1(4-11). Additionally, the combinatorial data from our previous and present experiments strongly suggest that the discriminable distribution sites in the central nervous system between hHK-1(4-11) and r/mHK-1 may be attributed to their discriminable analgesic effects. Altogether, our findings will not only contribute to the understanding of the complicated mechanisms regarding the nociceptive modulation of hemokinin-1 as well as its active fragments at supraspinal level, but may also lead to novel pharmacological interventions.
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0090446
fulltext: fulltext
issn:
  • 19326203
  • 1932-6203
url: Link


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titleHemokinin-1(4-11)-induced analgesia selectively up-regulates δ-opioid receptor expression in mice.
creatorFu, Cai-Yun ; Xia, Rui-Long ; Zhang, Teng-Fei ; Lu, Yan ; Zhang, Shi-Fu ; Yu, Zhi-Qiang ; Jin, Tao ; Mou, Xiao-Zhou
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identifierE-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0090446
subjectAnalgesia–Drug Effects ; Animals–Administration & Dosage ; Blotting, Western–Pharmacology ; Female–Genetics ; Gene Expression–Metabolism ; Humans–Genetics ; Injections, Intraventricular–Metabolism ; Male–Genetics ; Mice, Inbred Icr–Metabolism ; Peptide Fragments–Genetics ; Pro-Opiomelanocortin–Metabolism ; Protein Precursors–Administration & Dosage ; Receptors, Opioid, Delta–Chemistry ; Receptors, Opioid, Mu–Genetics ; Reverse Transcriptase Polymerase Chain Reaction–Metabolism ; Tachykinins–Pharmacology ; Up-Regulation–Drug Effects ; Peptide Fragments ; Protein Precursors ; Receptors, Opioid, Delta ; Receptors, Opioid, Mu ; Tachykinins ; Hemokinin-1 ; Preprotachykinin ; Pro-Opiomelanocortin
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descriptionOur previous studies have shown that an active fragment of human tachykinins (hHK-1(4-11)) produced an opioid-independent analgesia after intracerebroventricular (i.c.v.) injection in mice, which has been markedly enhanced by a [delta] OR antagonist, naltrindole hydrochloride (NTI). In this study, we have further characterized the in vivo analgesia after i.c.v. injection of hHK-1(4-11) in mouse model. Our qRT-PCR results showed that the mRNA levels of several ligands and receptors (e.g. PPT-A, PPT-C, KOR, PDYN and PENK) have not changed significantly. Furthermore, neither transcription nor expression of NK.sub.1 receptor, MOR and POMC have changed noticeably. In contrast, both mRNA and protein levels of DOR have been up-regulated significantly, indicating that the enhanced expression of [delta] opioid receptor negatively modulates the analgesia induced by i.c.v. injection of hHK-1(4-11). Additionally, the combinatorial data from our previous and present experiments strongly suggest that the discriminable distribution sites in the central nervous system between hHK-1(4-11) and r/mHK-1 may be attributed to their discriminable analgesic effects. Altogether, our findings will not only contribute to the understanding of the complicated mechanisms regarding the nociceptive modulation of hemokinin-1 as well as its active fragments at supraspinal level, but may also lead to novel pharmacological interventions.
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titleHemokinin-1(4-11)-induced analgesia selectively up-regulates δ-opioid receptor expression in mice.
authorFu, Cai-Yun ; Xia, Rui-Long ; Zhang, Teng-Fei ; Lu, Yan ; Zhang, Shi-Fu ; Yu, Zhi-Qiang ; Jin, Tao ; Mou, Xiao-Zhou
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