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Radiofrequency Ablation of Premature Ventricular Ectopy Improves the Efficacy of Cardiac Resynchronization Therapy in Nonresponders

Objectives This study sought to examine whether suppressing premature ventricular contractions (PVC) using radiofrequency ablation improves effectiveness of the cardiac resynchronization therapy (CRT) in nonresponders. Background CRT is an effective strategy for drug refractory congestive heart fail... Full description

Journal Title: Journal of the American College of Cardiology Oct 16, 2012, Vol.60(16), pp.1531-9
Main Author: Lakkireddy, Dhanunjaya
Other Authors: Di Biase, Luigi , Ryschon, Kay , Biria, Mazda , Swarup, Vijay , Reddy, Yeruva , Verma, Atul , Bommana, Sudharani , Burkhardt, David , Dendi, Raghuveer , Dello Russo, Antonio , Casella, Michela , Carbucicchio, Corrado , Tondo, Claudio , Dawn, Buddhadeb , Natale, Andrea
Format: Electronic Article Electronic Article
Language: English
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ID: ISSN: 07351097 ; E-ISSN: 15583597 ; DOI: 10.1016/j.jacc.2012.06.035
Link: http://search.proquest.com/docview/1506422613/?pq-origsite=primo
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title: Radiofrequency Ablation of Premature Ventricular Ectopy Improves the Efficacy of Cardiac Resynchronization Therapy in Nonresponders
format: Article
creator:
  • Lakkireddy, Dhanunjaya
  • Di Biase, Luigi
  • Ryschon, Kay
  • Biria, Mazda
  • Swarup, Vijay
  • Reddy, Yeruva
  • Verma, Atul
  • Bommana, Sudharani
  • Burkhardt, David
  • Dendi, Raghuveer
  • Dello Russo, Antonio
  • Casella, Michela
  • Carbucicchio, Corrado
  • Tondo, Claudio
  • Dawn, Buddhadeb
  • Natale, Andrea
subjects:
  • Aged–Surgery
  • Cardiac Resynchronization Therapy–Ultrasonography
  • Catheter Ablation–Ultrasonography
  • Echocardiography–Ultrasonography
  • Female–Ultrasonography
  • Humans–Ultrasonography
  • Male–Ultrasonography
  • Middle Aged–Ultrasonography
  • Prospective Studies–Ultrasonography
  • Ventricular Premature Complexes–Ultrasonography
  • Ventricular Premature Complexes–Ultrasonography
  • California
  • Drug Therapy
  • Heart Attacks
  • Catheters
  • Studies
  • Heart Failure
  • Cardiomyopathy
ispartof: Journal of the American College of Cardiology, Oct 16, 2012, Vol.60(16), pp.1531-9
description: Objectives This study sought to examine whether suppressing premature ventricular contractions (PVC) using radiofrequency ablation improves effectiveness of the cardiac resynchronization therapy (CRT) in nonresponders. Background CRT is an effective strategy for drug refractory congestive heart failure. However, one-third of patients with CRT do not respond clinically, and the causes for nonresponse are poorly understood. Whether frequent PVC contribute to CRT nonresponse remains unknown. Methods In this multicenter study, CRT nonresponders with >10,000 PVC in 24 h who underwent PVC ablation were enrolled from a prospective database. Results Sixty-five subjects (age 66.6 ± 12.4 years, 78% men, QRS duration of 155 ± 18 ms) had radiofrequency ablation of PVC from 76 foci. Acute and long-term success rates of ablation were 91% and 88% in 12 ± 4 months of follow-up. There was significant improvement in left ventricular (LV) ejection fraction (26.2 ± 5.5% to 32.7 ± 6.7 %, p < 0.001), LV end-systolic...
language: eng
source:
identifier: ISSN: 07351097 ; E-ISSN: 15583597 ; DOI: 10.1016/j.jacc.2012.06.035
fulltext: fulltext
issn:
  • 07351097
  • 0735-1097
  • 15583597
  • 1558-3597
url: Link


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titleRadiofrequency Ablation of Premature Ventricular Ectopy Improves the Efficacy of Cardiac Resynchronization Therapy in Nonresponders
creatorLakkireddy, Dhanunjaya ; Di Biase, Luigi ; Ryschon, Kay ; Biria, Mazda ; Swarup, Vijay ; Reddy, Yeruva ; Verma, Atul ; Bommana, Sudharani ; Burkhardt, David ; Dendi, Raghuveer ; Dello Russo, Antonio ; Casella, Michela ; Carbucicchio, Corrado ; Tondo, Claudio ; Dawn, Buddhadeb ; Natale, Andrea
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subjectAged–Surgery ; Cardiac Resynchronization Therapy–Ultrasonography ; Catheter Ablation–Ultrasonography ; Echocardiography–Ultrasonography ; Female–Ultrasonography ; Humans–Ultrasonography ; Male–Ultrasonography ; Middle Aged–Ultrasonography ; Prospective Studies–Ultrasonography ; Ventricular Premature Complexes–Ultrasonography ; Ventricular Premature Complexes–Ultrasonography ; California ; Drug Therapy ; Heart Attacks ; Catheters ; Studies ; Heart Failure ; Cardiomyopathy
descriptionObjectives This study sought to examine whether suppressing premature ventricular contractions (PVC) using radiofrequency ablation improves effectiveness of the cardiac resynchronization therapy (CRT) in nonresponders. Background CRT is an effective strategy for drug refractory congestive heart failure. However, one-third of patients with CRT do not respond clinically, and the causes for nonresponse are poorly understood. Whether frequent PVC contribute to CRT nonresponse remains unknown. Methods In this multicenter study, CRT nonresponders with >10,000 PVC in 24 h who underwent PVC ablation were enrolled from a prospective database. Results Sixty-five subjects (age 66.6 ± 12.4 years, 78% men, QRS duration of 155 ± 18 ms) had radiofrequency ablation of PVC from 76 foci. Acute and long-term success rates of ablation were 91% and 88% in 12 ± 4 months of follow-up. There was significant improvement in left ventricular (LV) ejection fraction (26.2 ± 5.5% to 32.7 ± 6.7 %, p < 0.001), LV end-systolic...
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titleRadiofrequency Ablation of Premature Ventricular Ectopy Improves the Efficacy of Cardiac Resynchronization Therapy in Nonresponders
descriptionObjectives This study sought to examine whether suppressing premature ventricular contractions (PVC) using radiofrequency ablation improves effectiveness of the cardiac resynchronization therapy (CRT) in nonresponders. Background CRT is an effective strategy for drug refractory congestive heart failure. However, one-third of patients with CRT do not respond clinically, and the causes for nonresponse are poorly understood. Whether frequent PVC contribute to CRT nonresponse remains unknown. Methods In this multicenter study, CRT nonresponders with >10,000 PVC in 24 h who underwent PVC ablation were enrolled from a prospective database. Results Sixty-five subjects (age 66.6 ± 12.4 years, 78% men, QRS duration of 155 ± 18 ms) had radiofrequency ablation of PVC from 76 foci. Acute and long-term success rates of ablation were 91% and 88% in 12 ± 4 months of follow-up. There was significant improvement in left ventricular (LV) ejection fraction (26.2 ± 5.5% to 32.7 ± 6.7 %, p < 0.001), LV end-systolic...
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titleRadiofrequency Ablation of Premature Ventricular Ectopy Improves the Efficacy of Cardiac Resynchronization Therapy in Nonresponders
authorLakkireddy, Dhanunjaya ; Di Biase, Luigi ; Ryschon, Kay ; Biria, Mazda ; Swarup, Vijay ; Reddy, Yeruva ; Verma, Atul ; Bommana, Sudharani ; Burkhardt, David ; Dendi, Raghuveer ; Dello Russo, Antonio ; Casella, Michela ; Carbucicchio, Corrado ; Tondo, Claudio ; Dawn, Buddhadeb ; Natale, Andrea
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8Prospective Studies–Ultrasonography
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12Heart Attacks
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14Studies
15Heart Failure
16Cardiomyopathy
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abstractObjectives This study sought to examine whether suppressing premature ventricular contractions (PVC) using radiofrequency ablation improves effectiveness of the cardiac resynchronization therapy (CRT) in nonresponders. Background CRT is an effective strategy for drug refractory congestive heart failure. However, one-third of patients with CRT do not respond clinically, and the causes for nonresponse are poorly understood. Whether frequent PVC contribute to CRT nonresponse remains unknown. Methods In this multicenter study, CRT nonresponders with >10,000 PVC in 24 h who underwent PVC ablation were enrolled from a prospective database. Results Sixty-five subjects (age 66.6 ± 12.4 years, 78% men, QRS duration of 155 ± 18 ms) had radiofrequency ablation of PVC from 76 foci. Acute and long-term success rates of ablation were 91% and 88% in 12 ± 4 months of follow-up. There was significant improvement in left ventricular (LV) ejection fraction (26.2 ± 5.5% to 32.7 ± 6.7 %, p < 0.001), LV end-systolic...
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date2012-10-16