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Susceptibility loci for pigmentation and melanoma in relation to Parkinson's disease.

Growing evidence suggests that Parkinson's disease (PD) patients have a lower risk for most types of cancer except for melanoma, which has a modest positive association with PD. Pigmentation genes have been hypothesized to contribute to this association. We therefore examined whether genetic suscept... Full description

Journal Title: Neurobiology of aging June 2014, Vol.35(6), pp.1512.e5-1512.e10
Main Author: Dong, Jing
Other Authors: Gao, Jianjun , Nalls, Michael , Gao, Xiang , Huang, Xuemei , Han, Jiali , Singleton, Andrew B , Chen, Honglei , Dong, Jing
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1558-1497 ; DOI: 10.1016/j.neurobiolaging.2013.12.020
Link: http://search.proquest.com/docview/1508947333/?pq-origsite=primo
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title: Susceptibility loci for pigmentation and melanoma in relation to Parkinson's disease.
format: Article
creator:
  • Dong, Jing
  • Gao, Jianjun
  • Nalls, Michael
  • Gao, Xiang
  • Huang, Xuemei
  • Han, Jiali
  • Singleton, Andrew B
  • Chen, Honglei
  • Dong, Jing
subjects:
  • Case-Control Studies–Genetics
  • Female–Genetics
  • Genetic Predisposition to Disease–Genetics
  • Genome-Wide Association Study–Genetics
  • Humans–Genetics
  • Male–Genetics
  • Melanoma–Genetics
  • Parkinson Disease–Genetics
  • Phenotype–Genetics
  • Pigmentation–Genetics
  • Polymorphism, Single Nucleotide–Genetics
  • Risk–Genetics
  • Melanoma
  • Parkinson'S Disease
  • Pigmentation
  • Susceptibility
ispartof: Neurobiology of aging, June 2014, Vol.35(6), pp.1512.e5-1512.e10
description: Growing evidence suggests that Parkinson's disease (PD) patients have a lower risk for most types of cancer except for melanoma, which has a modest positive association with PD. Pigmentation genes have been hypothesized to contribute to this association. We therefore examined whether genetic susceptibility loci for pigmentation or melanoma was associated with PD risk in 2 large independent datasets. In the Parkinson's Genes and Environment (PAGE) study, we examined 11 single-nucleotide polymorphisms (SNPs) identified from previous genome-wide association studies (GWAS) of pigmentation or melanoma in relation to PD among 808 PD cases and 1623 controls; furthermore, we also examined the colors of hair, eye, or skin and melanoma in relation to PD. In the International Parkinson's Disease Genomic Consortium (IPDGC), we examined a broader selection of 360 pigmentation or melanoma GWAS SNPs in relation to PD among 5,333 PD cases and 12,019 controls. All participants were non-Hispanic Whites. As expected, in the PAGE study, most SNPs were associated with 1 or more pigmentation phenotypes. However, neither these SNPs nor pigmentation phenotypes were associated with PD risk after Bonferroni correction with the exception of rs4911414 at the ASIP gene (p = .001). A total of 18 PD cases (2.2%) and 26 controls (1.6%) had a diagnosis of melanoma with an odds ratio of 1.3 (95% confidence interval: 0.7–2.4). In the IPDGC analysis, none of the 360 SNPs, including rs4911414, were associated with PD risk after adjusting for multiple comparisons. In conclusion, we did not find significant associations between GWAS SNPs of pigmentation or melanoma and the risk for PD.
language: eng
source:
identifier: E-ISSN: 1558-1497 ; DOI: 10.1016/j.neurobiolaging.2013.12.020
fulltext: fulltext
issn:
  • 15581497
  • 1558-1497
url: Link


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titleSusceptibility loci for pigmentation and melanoma in relation to Parkinson's disease.
creatorDong, Jing ; Gao, Jianjun ; Nalls, Michael ; Gao, Xiang ; Huang, Xuemei ; Han, Jiali ; Singleton, Andrew B ; Chen, Honglei ; Dong, Jing
contributorNalls, Mike A (correspondence author) ; Plagnol, Vincent (record owner) ; Hernandez, Dena G ; Sharma, Manu ; Sheerin, Una-Marie ; Saad, Mohamad ; Simón-Sánchez, Javier ; Schulte, Claudia ; Lesage, Suzanne ; Sveinbjörnsdóttir, Sigurlaug ; Arepalli, Sampath ; Barker, Roger ; Ben-Shlomo, Yoav ; Berendse, Henk W ; Berg, Daniela ; Bhatia
ispartofNeurobiology of aging, June 2014, Vol.35(6), pp.1512.e5-1512.e10
identifierE-ISSN: 1558-1497 ; DOI: 10.1016/j.neurobiolaging.2013.12.020
subjectCase-Control Studies–Genetics ; Female–Genetics ; Genetic Predisposition to Disease–Genetics ; Genome-Wide Association Study–Genetics ; Humans–Genetics ; Male–Genetics ; Melanoma–Genetics ; Parkinson Disease–Genetics ; Phenotype–Genetics ; Pigmentation–Genetics ; Polymorphism, Single Nucleotide–Genetics ; Risk–Genetics ; Melanoma ; Parkinson'S Disease ; Pigmentation ; Susceptibility
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descriptionGrowing evidence suggests that Parkinson's disease (PD) patients have a lower risk for most types of cancer except for melanoma, which has a modest positive association with PD. Pigmentation genes have been hypothesized to contribute to this association. We therefore examined whether genetic susceptibility loci for pigmentation or melanoma was associated with PD risk in 2 large independent datasets. In the Parkinson's Genes and Environment (PAGE) study, we examined 11 single-nucleotide polymorphisms (SNPs) identified from previous genome-wide association studies (GWAS) of pigmentation or melanoma in relation to PD among 808 PD cases and 1623 controls; furthermore, we also examined the colors of hair, eye, or skin and melanoma in relation to PD. In the International Parkinson's Disease Genomic Consortium (IPDGC), we examined a broader selection of 360 pigmentation or melanoma GWAS SNPs in relation to PD among 5,333 PD cases and 12,019 controls. All participants were non-Hispanic Whites. As expected, in the PAGE study, most SNPs were associated with 1 or more pigmentation phenotypes. However, neither these SNPs nor pigmentation phenotypes were associated with PD risk after Bonferroni correction with the exception of rs4911414 at the ASIP gene (p = .001). A total of 18 PD cases (2.2%) and 26 controls (1.6%) had a diagnosis of melanoma with an odds ratio of 1.3 (95% confidence interval: 0.7–2.4). In the IPDGC analysis, none of the 360 SNPs, including rs4911414, were associated with PD risk after adjusting for multiple comparisons. In conclusion, we did not find significant associations between GWAS SNPs of pigmentation or melanoma and the risk for PD.
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titleSusceptibility loci for pigmentation and melanoma in relation to Parkinson's disease.
authorDong, Jing ; Gao, Jianjun ; Nalls, Michael ; Gao, Xiang ; Huang, Xuemei ; Han, Jiali ; Singleton, Andrew B ; Chen, Honglei ; Dong, Jing
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7Parkinson Disease–Genetics
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12Sheerin, Una-Marie
13Saad, Mohamad
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15Schulte, Claudia
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17Sveinbjörnsdóttir, Sigurlaug
18Arepalli, Sampath
19Barker, Roger
20Ben-Shlomo, Yoav
21Berendse, Henk W
22Berg, Daniela
23Bhatia, Kailash
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25Biffi, Alessandro
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27Bochdanovits, Zoltan
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29Bras, Jose M
30Brockmann, Kathrin
31Brooks, Janet
32Burn, David J
33Charlesworth, Gavin
34Chinnery, Patrick F
35Chong, Sean
36Clarke, Carl E
37Cookson, Mark R
38Cooper, J Mark
39Corvol, Jean Christophe
40Counsell, Carl
41Damier, Philippe
42Dartigues, Jean-François
43Deloukas, Panos
44Deuschl, Günther
45Dexter, David T
46van Dijk, Karin D
47Dillman, Allissa
48Durif, Frank
49Dürr, Alexandra
50Edkins, Sarah
51Evans, Jonathan R
52Foltynie, Thomas
53Gardner, Michelle
54Gibbs, J Raphael
55Goate, Alison
56Gray, Emma
57Guerreiro, Rita
58Gústafsson, Ómar
59Harris, Clare
60van Hilten, Jacobus J
61Hofman, Albert
62Hollenbeck, Albert
63Holton, Janice
64Hu, Michele
65Huber, Heiko
66Hudson, Gavin
67Hunt, Sarah E
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24Burn, David J
25Charlesworth, Gavin
26Chen, Honglei
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32Corvol, Jean Christophe
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34Damier, Philippe
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36Deloukas, Panos
37Deuschl, Günther
38Dexter, David T
39van Dijk, Karin D
40Dillman, Allissa
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43Dürr, Alexandra
44Edkins, Sarah
45Evans, Jonathan R
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47Gardner, Michelle
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49Goate, Alison
50Gray, Emma
51Guerreiro, Rita
52Gústafsson, Ómar
53Harris, Clare
54van Hilten, Jacobus J
55Hofman, Albert
56Hollenbeck, Albert
57Holton, Janice
58Hu, Michele
59Huang, Xuemei
60Huber, Heiko
61Hudson, Gavin
62Hunt, Sarah E
63Huttenlocher, Johanna
64Illig, Thomas
65Jónsson, Pálmi V
66Lambert, Jean-Charles
67Langford, Cordelia
68Lees, Andrew
69Lichtner, Peter
70Limousin, Patricia
71Lopez, Grisel
72Lorenz, Delia
73McNeill, Alisdair
74Moorby, Catriona
75Moore, Matthew
76Morris, Huw R
77Morrison, Karen E
78Mudanohwo, Ese
79O'Sullivan, Sean S
80Pearson, Justin
81Perlmutter, Joel S
82Pétursson, Hjörvar
83Pollak, Pierre
84Post, Bart
85Potter, Simon
86Ravina, Bernard
87Revesz, Tamas
88Riess, Olaf
89Rivadeneira, Fernando
90Rizzu, Patrizia
91Ryten, Mina
92Sawcer, Stephen
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94Scheffer, Hans
95Shaw, Karen
96Shoulson, Ira
97Sidransky, Ellen
98Smith, Colin
99Spencer, Chris C A
100...
atitleSusceptibility loci for pigmentation and melanoma in relation to Parkinson's disease.
jtitleNeurobiology of aging
risdate20140601
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date2014-06-01