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Effects of 1-Year Intervention with a Mediterranean Diet on Plasma Fatty Acid Composition and Metabolic Syndrome in a Population at High Cardiovascular Risk

Background & Aims Metabolic syndrome (MetS) has become an important public concern due to its increasing prevalence. An altered fatty acid composition has been associated with MetS, but the Mediterranean diet has been shown to have a protective effect. The aim of the present study was to analyze the... Full description

Journal Title: PLoS One Mar 2014, Vol.9(3), p.e85202
Main Author: Mayneris-Perxachs, Jordi
Other Authors: Sala-Vila, Aleix , Chisaguano, Maribel , Castellote, Ana , Estruch, Ramón , Covas, María , Fitó, Montserrat , Salas-Salvadó, Jordi , Martínez-González, Miguel , Lamuela-Raventós, Rosa , Ros, Emilio , López-Sabater, M
Format: Electronic Article Electronic Article
Language: English
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ID: E-ISSN: 19326203 ; DOI: 10.1371/journal.pone.0085202
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title: Effects of 1-Year Intervention with a Mediterranean Diet on Plasma Fatty Acid Composition and Metabolic Syndrome in a Population at High Cardiovascular Risk
format: Article
creator:
  • Mayneris-Perxachs, Jordi
  • Sala-Vila, Aleix
  • Chisaguano, Maribel
  • Castellote, Ana
  • Estruch, Ramón
  • Covas, María
  • Fitó, Montserrat
  • Salas-Salvadó, Jordi
  • Martínez-González, Miguel
  • Lamuela-Raventós, Rosa
  • Ros, Emilio
  • López-Sabater, M
subjects:
  • Spain
  • Diabetes
  • Food Science
  • Plasma
  • Diet
  • Fats
  • Epidemiology
  • Nutrition Research
  • Acids
  • Public Concern
  • Cardiovascular Diseases
  • Fatty Acids
  • Hospitals
  • Biomedical Research
  • Fats and Oils
  • Diet
  • Insulin
  • Lipids
  • Metabolic Disorders
  • Body Weight Gain
  • Reversion
  • Oils & Fats
  • Breast Cancer
  • Reversion
  • Bioindicators
  • Pharmacy
  • Fatty Acids
  • Weight Control
  • Studies
  • Health Care
  • Endocrinology
  • Mens Health
  • Cardiovascular Diseases
  • Nuts
  • Fatty Acid Composition
  • Obesity
  • Medical Research
  • Cardiovascular Disease
  • Public Health
  • Metabolic Syndrome
  • Olive Oil
  • Biomarkers
  • Intervention
  • Preventive Medicine
  • Olive Oil
  • Health Risks
  • Food
  • University of Barcelona
  • Fats
  • Vegetable Oils
  • Diet
  • Diet and Type 2 Diabetes
  • Blood Plasma
  • Fatty Acids
  • Biomarkers
  • Cardiovascular Diseases
ispartof: PLoS One, Mar 2014, Vol.9(3), p.e85202
description: Background & Aims Metabolic syndrome (MetS) has become an important public concern due to its increasing prevalence. An altered fatty acid composition has been associated with MetS, but the Mediterranean diet has been shown to have a protective effect. The aim of the present study was to analyze the influence of a Mediterranean dietary pattern, as assessed by the biomarkers of food supplied, on the plasma fatty acid composition and its relation with MetS after 1 year of intervention. Methods A total of 424 subjects were randomly selected from the PREDIMED randomized dietary trial after completing a 1-year intervention program. Participants aged 55 to 80 years and at high risk of cardiovascular disease were randomly assigned to three dietary interventions: Mediterranean diet supplemented with virgin olive oil or nuts, or a low-fat diet. Results After 1 year of intervention participants in the virgin olive oil group showed significantly increased plasma concentrations of palmitic and oleic acids, but reduced proportions of margaric, stearic, and linoleic acids. In turn, subjects in the nut group showed significantly increased levels of palmitic, linoleic, and α-linolenic acids, but reduced proportions of myristic, margaric, palmitoleic, and dihommo-γ-linoleic acids. Increases in the biomarkers of foods supplied to the Mediterranean diet groups, i.e., oleic and α-linolenic acids, were beneficially associated with the incidence, reversion and prevalence of MetS. No weight changes were observed among participants. Conclusions The nut and olive oil diets induced a fatty acid composition that has been shown to be beneficial in the face of MetS. Therefore, a Mediterranean diet rich in fats of vegetable origin may be a useful tool for the management of MetS without the need for concerns over weight gain due to its high fat content. Trial Registration Controlled-Trials.com ISRCTN35739639
language: eng
source:
identifier: E-ISSN: 19326203 ; DOI: 10.1371/journal.pone.0085202
fulltext: fulltext_linktorsrc
issn:
  • 19326203
  • 1932-6203
url: Link


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titleEffects of 1-Year Intervention with a Mediterranean Diet on Plasma Fatty Acid Composition and Metabolic Syndrome in a Population at High Cardiovascular Risk
creatorMayneris-Perxachs, Jordi ; Sala-Vila, Aleix ; Chisaguano, Maribel ; Castellote, Ana ; Estruch, Ramón ; Covas, María ; Fitó, Montserrat ; Salas-Salvadó, Jordi ; Martínez-González, Miguel ; Lamuela-Raventós, Rosa ; Ros, Emilio ; López-Sabater, M
ispartofPLoS One, Mar 2014, Vol.9(3), p.e85202
identifierE-ISSN: 19326203 ; DOI: 10.1371/journal.pone.0085202
subjectSpain ; Diabetes ; Food Science ; Plasma ; Diet ; Fats ; Epidemiology ; Nutrition Research ; Acids ; Public Concern ; Cardiovascular Diseases ; Fatty Acids ; Hospitals ; Biomedical Research ; Fats and Oils ; Diet ; Insulin ; Lipids ; Metabolic Disorders ; Body Weight Gain ; Reversion ; Oils & Fats ; Breast Cancer ; Reversion ; Bioindicators ; Pharmacy ; Fatty Acids ; Weight Control ; Studies ; Health Care ; Endocrinology ; Mens Health ; Cardiovascular Diseases ; Nuts ; Fatty Acid Composition ; Obesity ; Medical Research ; Cardiovascular Disease ; Public Health ; Metabolic Syndrome ; Olive Oil ; Biomarkers ; Intervention ; Preventive Medicine ; Olive Oil ; Health Risks ; Food ; University of Barcelona ; Fats ; Vegetable Oils ; Diet ; Diet and Type 2 Diabetes ; Blood Plasma ; Fatty Acids ; Biomarkers ; Cardiovascular Diseases
descriptionBackground & Aims Metabolic syndrome (MetS) has become an important public concern due to its increasing prevalence. An altered fatty acid composition has been associated with MetS, but the Mediterranean diet has been shown to have a protective effect. The aim of the present study was to analyze the influence of a Mediterranean dietary pattern, as assessed by the biomarkers of food supplied, on the plasma fatty acid composition and its relation with MetS after 1 year of intervention. Methods A total of 424 subjects were randomly selected from the PREDIMED randomized dietary trial after completing a 1-year intervention program. Participants aged 55 to 80 years and at high risk of cardiovascular disease were randomly assigned to three dietary interventions: Mediterranean diet supplemented with virgin olive oil or nuts, or a low-fat diet. Results After 1 year of intervention participants in the virgin olive oil group showed significantly increased plasma concentrations of palmitic and oleic acids, but reduced proportions of margaric, stearic, and linoleic acids. In turn, subjects in the nut group showed significantly increased levels of palmitic, linoleic, and α-linolenic acids, but reduced proportions of myristic, margaric, palmitoleic, and dihommo-γ-linoleic acids. Increases in the biomarkers of foods supplied to the Mediterranean diet groups, i.e., oleic and α-linolenic acids, were beneficially associated with the incidence, reversion and prevalence of MetS. No weight changes were observed among participants. Conclusions The nut and olive oil diets induced a fatty acid composition that has been shown to be beneficial in the face of MetS. Therefore, a Mediterranean diet rich in fats of vegetable origin may be a useful tool for the management of MetS without the need for concerns over weight gain due to its high fat content. Trial Registration Controlled-Trials.com ISRCTN35739639
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titleEffects of 1-Year Intervention with a Mediterranean Diet on Plasma Fatty Acid Composition and Metabolic Syndrome in a Population at High Cardiovascular Risk
descriptionBackground & Aims Metabolic syndrome (MetS) has become an important public concern due to its increasing prevalence. An altered fatty acid composition has been associated with MetS, but the Mediterranean diet has been shown to have a protective effect. The aim of the present study was to analyze the influence of a Mediterranean dietary pattern, as assessed by the biomarkers of food supplied, on the plasma fatty acid composition and its relation with MetS after 1 year of intervention. Methods A total of 424 subjects were randomly selected from the PREDIMED randomized dietary trial after completing a 1-year intervention program. Participants aged 55 to 80 years and at high risk of cardiovascular disease were randomly assigned to three dietary interventions: Mediterranean diet supplemented with virgin olive oil or nuts, or a low-fat diet. Results After 1 year of intervention participants in the virgin olive oil group showed significantly increased plasma concentrations of palmitic and oleic acids, but reduced proportions of margaric, stearic, and linoleic acids. In turn, subjects in the nut group showed significantly increased levels of palmitic, linoleic, and α-linolenic acids, but reduced proportions of myristic, margaric, palmitoleic, and dihommo-γ-linoleic acids. Increases in the biomarkers of foods supplied to the Mediterranean diet groups, i.e., oleic and α-linolenic acids, were beneficially associated with the incidence, reversion and prevalence of MetS. No weight changes were observed among participants. Conclusions The nut and olive oil diets induced a fatty acid composition that has been shown to be beneficial in the face of MetS. Therefore, a Mediterranean diet rich in fats of vegetable origin may be a useful tool for the management of MetS without the need for concerns over weight gain due to its high fat content. Trial Registration Controlled-Trials.com ISRCTN35739639
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titleEffects of 1-Year Intervention with a Mediterranean Diet on Plasma Fatty Acid Composition and Metabolic Syndrome in a Population at High Cardiovascular Risk
authorMayneris-Perxachs, Jordi ; Sala-Vila, Aleix ; Chisaguano, Maribel ; Castellote, Ana ; Estruch, Ramón ; Covas, María ; Fitó, Montserrat ; Salas-Salvadó, Jordi ; Martínez-González, Miguel ; Lamuela-Raventós, Rosa ; Ros, Emilio ; López-Sabater, M
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2Food Science
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4Diet
5Fats
6Epidemiology
7Nutrition Research
8Acids
9Public Concern
10Cardiovascular Diseases
11Fatty Acids
12Hospitals
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abstractBackground & Aims Metabolic syndrome (MetS) has become an important public concern due to its increasing prevalence. An altered fatty acid composition has been associated with MetS, but the Mediterranean diet has been shown to have a protective effect. The aim of the present study was to analyze the influence of a Mediterranean dietary pattern, as assessed by the biomarkers of food supplied, on the plasma fatty acid composition and its relation with MetS after 1 year of intervention. Methods A total of 424 subjects were randomly selected from the PREDIMED randomized dietary trial after completing a 1-year intervention program. Participants aged 55 to 80 years and at high risk of cardiovascular disease were randomly assigned to three dietary interventions: Mediterranean diet supplemented with virgin olive oil or nuts, or a low-fat diet. Results After 1 year of intervention participants in the virgin olive oil group showed significantly increased plasma concentrations of palmitic and oleic acids, but reduced proportions of margaric, stearic, and linoleic acids. In turn, subjects in the nut group showed significantly increased levels of palmitic, linoleic, and α-linolenic acids, but reduced proportions of myristic, margaric, palmitoleic, and dihommo-γ-linoleic acids. Increases in the biomarkers of foods supplied to the Mediterranean diet groups, i.e., oleic and α-linolenic acids, were beneficially associated with the incidence, reversion and prevalence of MetS. No weight changes were observed among participants. Conclusions The nut and olive oil diets induced a fatty acid composition that has been shown to be beneficial in the face of MetS. Therefore, a Mediterranean diet rich in fats of vegetable origin may be a useful tool for the management of MetS without the need for concerns over weight gain due to its high fat content. Trial Registration Controlled-Trials.com ISRCTN35739639
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pubPublic Library of Science
doi10.1371/journal.pone.0085202
urlhttp://search.proquest.com/docview/1508982050/
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date2014-03-01