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Co-Delivery of Doxorubicin and SATB1 shRNA by Thermosensitive Magnetic Cationic Liposomes for Gastric Cancer Therapy

In previous a study, we had developed a novel thermosensitive magnetic delivery system based on liposomes. This study aimed to evaluate the efficiency of this system for the co-delivery of both drugs and genes to the same cell and its anti-tumor effects on gastric cancer. Doxorubicin (DOX) and SATB1... Full description

Journal Title: PLoS One Mar 2014, Vol.9(3), p.e92924
Main Author: Zhao, Peng
Other Authors: Wang, Chenxiao , Fang, Erhu , Lu, Xiaoming , Wang, Guobin , Tong, Qiang
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 19326203 ; DOI: 10.1371/journal.pone.0092924
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recordid: proquest1510768072
title: Co-Delivery of Doxorubicin and SATB1 shRNA by Thermosensitive Magnetic Cationic Liposomes for Gastric Cancer Therapy
format: Article
creator:
  • Zhao, Peng
  • Wang, Chenxiao
  • Fang, Erhu
  • Lu, Xiaoming
  • Wang, Guobin
  • Tong, Qiang
subjects:
  • United States–Us
  • Zhejiang China
  • Cytotoxicity
  • Gene Therapy
  • Liposomes
  • Science
  • Cancer
  • Nanoparticles
  • Cancer Therapies
  • Gene Therapy
  • Thermosensitive
  • Cholesterol
  • Doxorubicin
  • Biomedical Materials
  • In Vivo Methods and Tests
  • Toxicity
  • Thin Films
  • Cytotoxicity
  • Drug Resistance
  • Efficiency
  • Gene Silencing
  • Gastrointestinal Surgery
  • Chemotherapy
  • Gene Expression
  • Lung Cancer
  • Chemotherapy
  • Cancer
  • Anticancer Properties
  • Stomach Cancer
  • Drug Delivery Systems
  • Phase Transitions
  • Particle Size
  • Gastric Cancer
  • Biocompatibility
  • Methods
  • Drug Delivery
  • Chemotherapy
  • Doxorubicin
  • Liposomes
  • Drugs
  • Antitumor Agents
  • Gene Therapy
  • Chemotherapy
  • Liposomes
  • Small Interfering Rnas
  • Gastric Cancer
  • Apoptosis
  • Cytotoxicity
  • Cancer Chemotherapy
  • Magnetic Fields
  • Cancer Treatment
ispartof: PLoS One, Mar 2014, Vol.9(3), p.e92924
description: In previous a study, we had developed a novel thermosensitive magnetic delivery system based on liposomes. This study aimed to evaluate the efficiency of this system for the co-delivery of both drugs and genes to the same cell and its anti-tumor effects on gastric cancer. Doxorubicin (DOX) and SATB1 shRNA vector were loaded into the co-delivery system, and in vitro DOX thermosensitive release activity, targeted gene silencing efficiency, targeted cellular uptake, in vitro cytotoxicity, as well as in vivo anti-tumor activity were determined. The results showed that this co-delivery system had desirable targeted delivery efficacy, DOX thermosensitive release and SATB1 gene silencing. Moreover, the co-delivery of DOX and SATB1 shRNA exhibited enhanced activity to inhibit gastric cancer cell growth in vitro and in vivo, compared to single delivery. In conclusion, the novel thermosensitive magnetic drug and gene co-delivery system has promising application in combined chemotherapy and gene therapy for gastric cancer.
language: eng
source:
identifier: E-ISSN: 19326203 ; DOI: 10.1371/journal.pone.0092924
fulltext: fulltext_linktorsrc
issn:
  • 19326203
  • 1932-6203
url: Link


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titleCo-Delivery of Doxorubicin and SATB1 shRNA by Thermosensitive Magnetic Cationic Liposomes for Gastric Cancer Therapy
creatorZhao, Peng ; Wang, Chenxiao ; Fang, Erhu ; Lu, Xiaoming ; Wang, Guobin ; Tong, Qiang
ispartofPLoS One, Mar 2014, Vol.9(3), p.e92924
identifierE-ISSN: 19326203 ; DOI: 10.1371/journal.pone.0092924
subjectUnited States–Us ; Zhejiang China ; Cytotoxicity ; Gene Therapy ; Liposomes ; Science ; Cancer ; Nanoparticles ; Cancer Therapies ; Gene Therapy ; Thermosensitive ; Cholesterol ; Doxorubicin ; Biomedical Materials ; In Vivo Methods and Tests ; Toxicity ; Thin Films ; Cytotoxicity ; Drug Resistance ; Efficiency ; Gene Silencing ; Gastrointestinal Surgery ; Chemotherapy ; Gene Expression ; Lung Cancer ; Chemotherapy ; Cancer ; Anticancer Properties ; Stomach Cancer ; Drug Delivery Systems ; Phase Transitions ; Particle Size ; Gastric Cancer ; Biocompatibility ; Methods ; Drug Delivery ; Chemotherapy ; Doxorubicin ; Liposomes ; Drugs ; Antitumor Agents ; Gene Therapy ; Chemotherapy ; Liposomes ; Small Interfering Rnas ; Gastric Cancer ; Apoptosis ; Cytotoxicity ; Cancer Chemotherapy ; Magnetic Fields ; Cancer Treatment
descriptionIn previous a study, we had developed a novel thermosensitive magnetic delivery system based on liposomes. This study aimed to evaluate the efficiency of this system for the co-delivery of both drugs and genes to the same cell and its anti-tumor effects on gastric cancer. Doxorubicin (DOX) and SATB1 shRNA vector were loaded into the co-delivery system, and in vitro DOX thermosensitive release activity, targeted gene silencing efficiency, targeted cellular uptake, in vitro cytotoxicity, as well as in vivo anti-tumor activity were determined. The results showed that this co-delivery system had desirable targeted delivery efficacy, DOX thermosensitive release and SATB1 gene silencing. Moreover, the co-delivery of DOX and SATB1 shRNA exhibited enhanced activity to inhibit gastric cancer cell growth in vitro and in vivo, compared to single delivery. In conclusion, the novel thermosensitive magnetic drug and gene co-delivery system has promising application in combined chemotherapy and gene therapy for gastric cancer.
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titleCo-Delivery of Doxorubicin and SATB1 shRNA by Thermosensitive Magnetic Cationic Liposomes for Gastric Cancer Therapy
descriptionIn previous a study, we had developed a novel thermosensitive magnetic delivery system based on liposomes. This study aimed to evaluate the efficiency of this system for the co-delivery of both drugs and genes to the same cell and its anti-tumor effects on gastric cancer. Doxorubicin (DOX) and SATB1 shRNA vector were loaded into the co-delivery system, and in vitro DOX thermosensitive release activity, targeted gene silencing efficiency, targeted cellular uptake, in vitro cytotoxicity, as well as in vivo anti-tumor activity were determined. The results showed that this co-delivery system had desirable targeted delivery efficacy, DOX thermosensitive release and SATB1 gene silencing. Moreover, the co-delivery of DOX and SATB1 shRNA exhibited enhanced activity to inhibit gastric cancer cell growth in vitro and in vivo, compared to single delivery. In conclusion, the novel thermosensitive magnetic drug and gene co-delivery system has promising application in combined chemotherapy and gene therapy for gastric cancer.
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titleCo-Delivery of Doxorubicin and SATB1 shRNA by Thermosensitive Magnetic Cationic Liposomes for Gastric Cancer Therapy
authorZhao, Peng ; Wang, Chenxiao ; Fang, Erhu ; Lu, Xiaoming ; Wang, Guobin ; Tong, Qiang
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6Cancer
7Nanoparticles
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9Thermosensitive
10Cholesterol
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12Biomedical Materials
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abstractIn previous a study, we had developed a novel thermosensitive magnetic delivery system based on liposomes. This study aimed to evaluate the efficiency of this system for the co-delivery of both drugs and genes to the same cell and its anti-tumor effects on gastric cancer. Doxorubicin (DOX) and SATB1 shRNA vector were loaded into the co-delivery system, and in vitro DOX thermosensitive release activity, targeted gene silencing efficiency, targeted cellular uptake, in vitro cytotoxicity, as well as in vivo anti-tumor activity were determined. The results showed that this co-delivery system had desirable targeted delivery efficacy, DOX thermosensitive release and SATB1 gene silencing. Moreover, the co-delivery of DOX and SATB1 shRNA exhibited enhanced activity to inhibit gastric cancer cell growth in vitro and in vivo, compared to single delivery. In conclusion, the novel thermosensitive magnetic drug and gene co-delivery system has promising application in combined chemotherapy and gene therapy for gastric cancer.
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