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C1420T polymorphism of cytosolic serine hydroxymethyltransferase and risk of cancer: a meta-analysis.

A series of studies have explored the role of cytosolic serine hydroxymethyltransferase (SHMT1) C1420T polymorphism in cancer risk, but their results were conflicting rather than conclusive. To derive a more precise estimation of the association between C1420T and cancer risk, the present meta-analy... Full description

Journal Title: Asian Pacific journal of cancer prevention : APJCP 2014, Vol.15(5), pp.2257-2262
Main Author: Zhong, Shan-Liang
Other Authors: Zhang, Jun , Hu, Qing , Chen, Wei-Xian , Ma, Teng-Fei , Zhao, Jian-Hua
Format: Electronic Article Electronic Article
Language: English
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ID: E-ISSN: 2476-762X
Link: http://search.proquest.com/docview/1515642069/?pq-origsite=primo
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recordid: proquest1515642069
title: C1420T polymorphism of cytosolic serine hydroxymethyltransferase and risk of cancer: a meta-analysis.
format: Article
creator:
  • Zhong, Shan-Liang
  • Zhang, Jun
  • Hu, Qing
  • Chen, Wei-Xian
  • Ma, Teng-Fei
  • Zhao, Jian-Hua
subjects:
  • Alleles–Methods
  • Case-Control Studies–Genetics
  • Genetic Association Studies–Genetics
  • Genetic Predisposition to Disease–Genetics
  • Genotype–Genetics
  • Glycine Hydroxymethyltransferase–Genetics
  • Humans–Genetics
  • Neoplasms–Genetics
  • Polymorphism, Genetic–Genetics
  • Risk–Genetics
  • Glycine Hydroxymethyltransferase
  • Shmt Protein, Human
ispartof: Asian Pacific journal of cancer prevention : APJCP, 2014, Vol.15(5), pp.2257-2262
description: A series of studies have explored the role of cytosolic serine hydroxymethyltransferase (SHMT1) C1420T polymorphism in cancer risk, but their results were conflicting rather than conclusive. To derive a more precise estimation of the association between C1420T and cancer risk, the present meta-analysis of 28 available studies with 15,121 cases and 18,023 controls was conducted. The results revealed that there was no significant association between the polymorphism and cancer risk overall. In stratified analysis by cancer type (breast cancer, gastrointestinal cancer, leukemia, lymphoma, and others), the results showed that 1420T allele was associated with decreased risk in leukemia (CT vs. CC: OR= 0.825, 95% CI =0.704-0.966; and CT+TT vs. CC: OR= 0.838, 95% CI = 0.722-0.973), but the same results were not present for other cancer types. When subgroup analysis was performed by source of control (population-based [PB] and hospital-based [HB]), a borderline inverse association was observed for the HB subgroup (CT vs. CC: OR= 0.917, 95% CI = 0.857-0.982) but not for the PB subgroup. Stratifying by geographic area (America, Asia and Europe), significant inverse association was only found in Asia subgroup (CT vs. CC: OR= 0.674, 95% CI = 0.522-0.870). In summary, the findings suggest that SHMT1 C1420T polymorphism is not associated with overall cancer development, but might decrease cancer susceptibility of Asians as well as reduce leukemia risk. Large well-designed epidemiological studies will be necessary to validate the risk identified in the current meta-analysis.
language: eng
source:
identifier: E-ISSN: 2476-762X
fulltext: fulltext
issn:
  • 2476762X
  • 2476-762X
url: Link


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titleC1420T polymorphism of cytosolic serine hydroxymethyltransferase and risk of cancer: a meta-analysis.
creatorZhong, Shan-Liang ; Zhang, Jun ; Hu, Qing ; Chen, Wei-Xian ; Ma, Teng-Fei ; Zhao, Jian-Hua
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identifierE-ISSN: 2476-762X
subjectAlleles–Methods ; Case-Control Studies–Genetics ; Genetic Association Studies–Genetics ; Genetic Predisposition to Disease–Genetics ; Genotype–Genetics ; Glycine Hydroxymethyltransferase–Genetics ; Humans–Genetics ; Neoplasms–Genetics ; Polymorphism, Genetic–Genetics ; Risk–Genetics ; Glycine Hydroxymethyltransferase ; Shmt Protein, Human
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descriptionA series of studies have explored the role of cytosolic serine hydroxymethyltransferase (SHMT1) C1420T polymorphism in cancer risk, but their results were conflicting rather than conclusive. To derive a more precise estimation of the association between C1420T and cancer risk, the present meta-analysis of 28 available studies with 15,121 cases and 18,023 controls was conducted. The results revealed that there was no significant association between the polymorphism and cancer risk overall. In stratified analysis by cancer type (breast cancer, gastrointestinal cancer, leukemia, lymphoma, and others), the results showed that 1420T allele was associated with decreased risk in leukemia (CT vs. CC: OR= 0.825, 95% CI =0.704-0.966; and CT+TT vs. CC: OR= 0.838, 95% CI = 0.722-0.973), but the same results were not present for other cancer types. When subgroup analysis was performed by source of control (population-based [PB] and hospital-based [HB]), a borderline inverse association was observed for the HB subgroup (CT vs. CC: OR= 0.917, 95% CI = 0.857-0.982) but not for the PB subgroup. Stratifying by geographic area (America, Asia and Europe), significant inverse association was only found in Asia subgroup (CT vs. CC: OR= 0.674, 95% CI = 0.522-0.870). In summary, the findings suggest that SHMT1 C1420T polymorphism is not associated with overall cancer development, but might decrease cancer susceptibility of Asians as well as reduce leukemia risk. Large well-designed epidemiological studies will be necessary to validate the risk identified in the current meta-analysis.
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