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Adipose Tissue Dendritic Cells Enhances Inflammation by Prompting the Generation of Th17 Cells: e92450

Background Obesity has become a global challenge for public health. It has been reported that obesity is associated with chronic inflammation. However, the mechanism for the chronic inflammation contributes to obesity remains elusive. Methodology/Principal Findings In our study, we found a novel CD1... Full description

Journal Title: PLoS ONE Mar 2014, Vol.9(3)
Main Author: Chen, Yanhong
Other Authors: Tian, Jie , Tian, Xinyu , Tang, Xinyi , Rui, Ke , Tong, Jia , Lu, Liwei , Xu, Huaxi , Wang, Shengjun
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0092450
Link: http://search.proquest.com/docview/1520374032/
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title: Adipose Tissue Dendritic Cells Enhances Inflammation by Prompting the Generation of Th17 Cells: e92450
format: Article
creator:
  • Chen, Yanhong
  • Tian, Jie
  • Tian, Xinyu
  • Tang, Xinyi
  • Rui, Ke
  • Tong, Jia
  • Lu, Liwei
  • Xu, Huaxi
  • Wang, Shengjun
subjects:
  • Interleukin 6
  • Obesity
  • Helper Cells
  • Cd86 Antigen
  • Spleen
  • Cd11c Antigen
  • Inflammation
  • Public Health
  • Dendritic Cells
  • Interleukin 23
  • High Fat Diet
  • Transforming Growth Factor- Beta
  • Cd80 Antigen
  • Adipose Tissue
  • Cd40 Antigen
  • Development, Aging & Organ Systems
ispartof: PLoS ONE, Mar 2014, Vol.9(3)
description: Background Obesity has become a global challenge for public health. It has been reported that obesity is associated with chronic inflammation. However, the mechanism for the chronic inflammation contributes to obesity remains elusive. Methodology/Principal Findings In our study, we found a novel CD11c+ dendritic cell subset existed in murine adipose tissues which was immature phenotype. Moreover, as compared to the lean controls, the number of CD11c+ DCs and CD4+IL-17+T cells were higher in adipose tissue of high fat diet (HFD) mice. Adipose tissues derived dendritic cells (ATDCs) displayed lower levels of CD40, CD80, CD86, MHCI and MHCII expression than splenic DCs (SPDCs). However, ATDCs showed higher levels of IL-6, TGF- beta and IL-23 secretion. Moreover, our in vitro experiments demonstrated that ATDCs were capable of promoting Th17 cell generation. Conclusions/Significance Our results indicate the existence of CD11c+ DCs in adipose tissues, which displays an immature phenotype but possessing pro-inflammatory function.
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0092450
fulltext: fulltext
issn:
  • 19326203
  • 1932-6203
url: Link


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titleAdipose Tissue Dendritic Cells Enhances Inflammation by Prompting the Generation of Th17 Cells: e92450
creatorChen, Yanhong ; Tian, Jie ; Tian, Xinyu ; Tang, Xinyi ; Rui, Ke ; Tong, Jia ; Lu, Liwei ; Xu, Huaxi ; Wang, Shengjun
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identifierE-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0092450
subjectInterleukin 6 ; Obesity ; Helper Cells ; Cd86 Antigen ; Spleen ; Cd11c Antigen ; Inflammation ; Public Health ; Dendritic Cells ; Interleukin 23 ; High Fat Diet ; Transforming Growth Factor- Beta ; Cd80 Antigen ; Adipose Tissue ; Cd40 Antigen ; Development, Aging & Organ Systems
descriptionBackground Obesity has become a global challenge for public health. It has been reported that obesity is associated with chronic inflammation. However, the mechanism for the chronic inflammation contributes to obesity remains elusive. Methodology/Principal Findings In our study, we found a novel CD11c+ dendritic cell subset existed in murine adipose tissues which was immature phenotype. Moreover, as compared to the lean controls, the number of CD11c+ DCs and CD4+IL-17+T cells were higher in adipose tissue of high fat diet (HFD) mice. Adipose tissues derived dendritic cells (ATDCs) displayed lower levels of CD40, CD80, CD86, MHCI and MHCII expression than splenic DCs (SPDCs). However, ATDCs showed higher levels of IL-6, TGF- beta and IL-23 secretion. Moreover, our in vitro experiments demonstrated that ATDCs were capable of promoting Th17 cell generation. Conclusions/Significance Our results indicate the existence of CD11c+ DCs in adipose tissues, which displays an immature phenotype but possessing pro-inflammatory function.
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titleAdipose Tissue Dendritic Cells Enhances Inflammation by Prompting the Generation of Th17 Cells: e92450
descriptionBackground Obesity has become a global challenge for public health. It has been reported that obesity is associated with chronic inflammation. However, the mechanism for the chronic inflammation contributes to obesity remains elusive. Methodology/Principal Findings In our study, we found a novel CD11c+ dendritic cell subset existed in murine adipose tissues which was immature phenotype. Moreover, as compared to the lean controls, the number of CD11c+ DCs and CD4+IL-17+T cells were higher in adipose tissue of high fat diet (HFD) mice. Adipose tissues derived dendritic cells (ATDCs) displayed lower levels of CD40, CD80, CD86, MHCI and MHCII expression than splenic DCs (SPDCs). However, ATDCs showed higher levels of IL-6, TGF- beta and IL-23 secretion. Moreover, our in vitro experiments demonstrated that ATDCs were capable of promoting Th17 cell generation. Conclusions/Significance Our results indicate the existence of CD11c+ DCs in adipose tissues, which displays an immature phenotype but possessing pro-inflammatory function.
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titleAdipose Tissue Dendritic Cells Enhances Inflammation by Prompting the Generation of Th17 Cells: e92450
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abstractBackground Obesity has become a global challenge for public health. It has been reported that obesity is associated with chronic inflammation. However, the mechanism for the chronic inflammation contributes to obesity remains elusive. Methodology/Principal Findings In our study, we found a novel CD11c+ dendritic cell subset existed in murine adipose tissues which was immature phenotype. Moreover, as compared to the lean controls, the number of CD11c+ DCs and CD4+IL-17+T cells were higher in adipose tissue of high fat diet (HFD) mice. Adipose tissues derived dendritic cells (ATDCs) displayed lower levels of CD40, CD80, CD86, MHCI and MHCII expression than splenic DCs (SPDCs). However, ATDCs showed higher levels of IL-6, TGF- beta and IL-23 secretion. Moreover, our in vitro experiments demonstrated that ATDCs were capable of promoting Th17 cell generation. Conclusions/Significance Our results indicate the existence of CD11c+ DCs in adipose tissues, which displays an immature phenotype but possessing pro-inflammatory function.
doi10.1371/journal.pone.0092450
urlhttp://search.proquest.com/docview/1520374032/