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Near infrared laser-induced targeted cancer therapy using thermoresponsive polymer encapsulated gold nanorods.

External stimuli, such as ultrasound, magnetic field, and light, can be applied to activate in vivo tumor targeting. Herein, we fabricated polymer encapsulated gold nanorods to couple the photothermal properties of gold nanorods and the thermo- and pH-responsive properties of polymers in a single na... Full description

Journal Title: Journal of the American Chemical Society May 21, 2014, Vol.136(20), pp.7317-7326
Main Author: Zhang, Zhenjiang
Other Authors: Wang, Jing , Nie, Xin , Wen, Tao , Ji, Yinglu , Wu, Xiaochun , Zhao, Yuliang , Chen, Chunying
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1520-5126 ; DOI: 1520-5126 ; DOI: 10.1021/ja412735p
Link: http://search.proquest.com/docview/1527328512/?pq-origsite=primo
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recordid: proquest1527328512
title: Near infrared laser-induced targeted cancer therapy using thermoresponsive polymer encapsulated gold nanorods.
format: Article
creator:
  • Zhang, Zhenjiang
  • Wang, Jing
  • Nie, Xin
  • Wen, Tao
  • Ji, Yinglu
  • Wu, Xiaochun
  • Zhao, Yuliang
  • Chen, Chunying
subjects:
  • Animals–Chemistry
  • Antineoplastic Agents–Pharmacology
  • Cell Line, Tumor–Drug Effects
  • Cell Survival–Chemistry
  • Dose-Response Relationship, Drug–Pharmacology
  • Doxorubicin–Chemistry
  • Drug Screening Assays, Antitumor–Chemistry
  • Gold–Chemistry
  • Hydrogen-Ion Concentration–Chemistry
  • Infrared Rays–Chemistry
  • Lasers–Chemistry
  • Mice–Chemistry
  • Nanocomposites–Chemistry
  • Nanotubes–Chemistry
  • Polymers–Chemistry
  • Structure-Activity Relationship–Chemistry
  • Temperature–Chemistry
  • Tissue Distribution–Chemistry
  • Antineoplastic Agents
  • Polymers
  • Gold
  • Doxorubicin
ispartof: Journal of the American Chemical Society, May 21, 2014, Vol.136(20), pp.7317-7326
description: External stimuli, such as ultrasound, magnetic field, and light, can be applied to activate in vivo tumor targeting. Herein, we fabricated polymer encapsulated gold nanorods to couple the photothermal properties of gold nanorods and the thermo- and pH-responsive properties of polymers in a single nanocomposite. The activation mechamism was thus transformed from heat to near-infrared (NIR) laser, which can be more easily controlled. Doxorubicin, a clinical anticancer drug, can be loaded into the nanocomposite through electrostatic interactions with high loading content up to 24%. The nanocomposite's accumulation in tumor post systematic administration can be significantly enhanced by NIR laser irradiation, providing a prerequisite for their therapeutic application which almost completely inhibited tumor growth and lung metastasis. Since laser can be manipulated very precisely and flexibly, the nanocomposite provides an ideally versatile platform to simultaneously deliver heat and anticancer drugs in a laser-activation mechanism with facile control of the area, time, and dosage. The NIR laser-induced targeted cancer thermo-chemotherapy without using targeting ligands represents a novel targeted anticancer strategy with facile control and practical efficacy.
language: eng
source:
identifier: E-ISSN: 1520-5126 ; DOI: 1520-5126 ; DOI: 10.1021/ja412735p
fulltext: no_fulltext
issn:
  • 15205126
  • 1520-5126
url: Link


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titleNear infrared laser-induced targeted cancer therapy using thermoresponsive polymer encapsulated gold nanorods.
creatorZhang, Zhenjiang ; Wang, Jing ; Nie, Xin ; Wen, Tao ; Ji, Yinglu ; Wu, Xiaochun ; Zhao, Yuliang ; Chen, Chunying
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subjectAnimals–Chemistry ; Antineoplastic Agents–Pharmacology ; Cell Line, Tumor–Drug Effects ; Cell Survival–Chemistry ; Dose-Response Relationship, Drug–Pharmacology ; Doxorubicin–Chemistry ; Drug Screening Assays, Antitumor–Chemistry ; Gold–Chemistry ; Hydrogen-Ion Concentration–Chemistry ; Infrared Rays–Chemistry ; Lasers–Chemistry ; Mice–Chemistry ; Nanocomposites–Chemistry ; Nanotubes–Chemistry ; Polymers–Chemistry ; Structure-Activity Relationship–Chemistry ; Temperature–Chemistry ; Tissue Distribution–Chemistry ; Antineoplastic Agents ; Polymers ; Gold ; Doxorubicin
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descriptionExternal stimuli, such as ultrasound, magnetic field, and light, can be applied to activate in vivo tumor targeting. Herein, we fabricated polymer encapsulated gold nanorods to couple the photothermal properties of gold nanorods and the thermo- and pH-responsive properties of polymers in a single nanocomposite. The activation mechamism was thus transformed from heat to near-infrared (NIR) laser, which can be more easily controlled. Doxorubicin, a clinical anticancer drug, can be loaded into the nanocomposite through electrostatic interactions with high loading content up to 24%. The nanocomposite's accumulation in tumor post systematic administration can be significantly enhanced by NIR laser irradiation, providing a prerequisite for their therapeutic application which almost completely inhibited tumor growth and lung metastasis. Since laser can be manipulated very precisely and flexibly, the nanocomposite provides an ideally versatile platform to simultaneously deliver heat and anticancer drugs in a laser-activation mechanism with facile control of the area, time, and dosage. The NIR laser-induced targeted cancer thermo-chemotherapy without using targeting ligands represents a novel targeted anticancer strategy with facile control and practical efficacy.
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titleNear infrared laser-induced targeted cancer therapy using thermoresponsive polymer encapsulated gold nanorods.
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titleNear infrared laser-induced targeted cancer therapy using thermoresponsive polymer encapsulated gold nanorods.
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