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High proportion of knowlesi malaria in recent malaria cases in Malaysia.

BACKGROUNDPlasmodium knowlesi is a simian parasite that has been recognized as the fifth species causing human malaria. Naturally-acquired P. knowlesi infection is widespread among human populations in Southeast Asia. The aim of this epidemiological study was to determine the incidence and distribut... Full description

Journal Title: Malaria journal May 3, 2014, Vol.13, p.168
Main Author: Yusof, Ruhani
Other Authors: Lau, Yee Ling , Mahmud, Rohela , Fong, Mun Yik , Jelip, Jenarun , Ngian, Hie Ung , Mustakim, Sahlawati , Hussin, Hani Mat , Marzuki, Noradilah , Mohd Ali, Marlindawati
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1475-2875 ; DOI: 1475-2875 ; DOI: 10.1186/1475-2875-13-168
Link: http://search.proquest.com/docview/1532942367/?pq-origsite=primo
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title: High proportion of knowlesi malaria in recent malaria cases in Malaysia.
format: Article
creator:
  • Yusof, Ruhani
  • Lau, Yee Ling
  • Mahmud, Rohela
  • Fong, Mun Yik
  • Jelip, Jenarun
  • Ngian, Hie Ung
  • Mustakim, Sahlawati
  • Hussin, Hani Mat
  • Marzuki, Noradilah
  • Mohd Ali, Marlindawati
subjects:
  • Adolescent–Genetics
  • Adult–Epidemiology
  • Aged–Parasitology
  • Aged, 80 and Over–Epidemiology
  • Child–Classification
  • Child, Preschool–Genetics
  • DNA, Ribosomal–Isolation & Purification
  • Female–Genetics
  • Humans–Genetics
  • Incidence–Genetics
  • Infant–Genetics
  • Infant, Newborn–Genetics
  • Malaria–Genetics
  • Malaysia–Genetics
  • Male–Genetics
  • Middle Aged–Genetics
  • Plasmodium–Genetics
  • RNA, Ribosomal, 18s–Genetics
  • Young Adult–Genetics
  • DNA, Ribosomal
  • RNA, Ribosomal, 18s
ispartof: Malaria journal, May 3, 2014, Vol.13, p.168
description: BACKGROUNDPlasmodium knowlesi is a simian parasite that has been recognized as the fifth species causing human malaria. Naturally-acquired P. knowlesi infection is widespread among human populations in Southeast Asia. The aim of this epidemiological study was to determine the incidence and distribution of malaria parasites, with a particular focus on human P. knowlesi infection in Malaysia. METHODSA total of 457 microscopically confirmed, malaria-positive blood samples were collected from 22 state and main district hospitals in Malaysia between September 2012 and December 2013. Nested PCR assay targeting the 18S rRNA gene was used to determine the infecting Plasmodium species. RESULTSA total of 453 samples were positive for Plasmodium species by using nested PCR assay. Plasmodium knowlesi was identified in 256 (56.5%) samples, followed by 133 (29.4%) cases of Plasmodium vivax, 49 (10.8%) cases of Plasmodium falciparum, two (0.4%) cases of Plasmodium ovale and one (0.2%) case of Plasmodium malariae. Twelve mixed infections were detected, including P. knowlesi/P. vivax (n = 10), P. knowlesi/P. falciparum (n = 1), and P. falciparum/P. vivax (n = 1). Notably, P. knowlesi (Included mixed infections involving P. knowlesi (P. knowlesi/P. vivax and P. knowlesi /P. falciparum)) showed the highest proportion in Sabah (84/115 cases, prevalence of 73.0%), Sarawak (83/120, 69.2%), Kelantan (42/56, 75.0%), Pahang (24/25, 96.0%), Johor (7/9, 77.8%), and Terengganu (4/5, 80.0%,). In contrast, the rates of P. knowlesi infection in Selangor and Negeri Sembilan were found to be 16.2% (18/111 cases) and 50.0% (5/10 cases), respectively. Sample of P. knowlesi was not obtained from Kuala Lumpur, Melaka, Perak, Pulau Pinang, and Perlis during the study period, while a microscopically-positive sample from Kedah was negative by PCR. CONCLUSIONIn addition to Sabah and Sarawak, which have been known for high prevalence of P. knowlesi infection, the findings from this study highlight the widespread distribution of P. knowlesi in many Peninsular Malaysia states.
language: eng
source:
identifier: E-ISSN: 1475-2875 ; DOI: 1475-2875 ; DOI: 10.1186/1475-2875-13-168
fulltext: fulltext
issn:
  • 14752875
  • 1475-2875
url: Link


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titleHigh proportion of knowlesi malaria in recent malaria cases in Malaysia.
creatorYusof, Ruhani ; Lau, Yee Ling ; Mahmud, Rohela ; Fong, Mun Yik ; Jelip, Jenarun ; Ngian, Hie Ung ; Mustakim, Sahlawati ; Hussin, Hani Mat ; Marzuki, Noradilah ; Mohd Ali, Marlindawati
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ispartofMalaria journal, May 3, 2014, Vol.13, p.168
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subjectAdolescent–Genetics ; Adult–Epidemiology ; Aged–Parasitology ; Aged, 80 and Over–Epidemiology ; Child–Classification ; Child, Preschool–Genetics ; DNA, Ribosomal–Isolation & Purification ; Female–Genetics ; Humans–Genetics ; Incidence–Genetics ; Infant–Genetics ; Infant, Newborn–Genetics ; Malaria–Genetics ; Malaysia–Genetics ; Male–Genetics ; Middle Aged–Genetics ; Plasmodium–Genetics ; RNA, Ribosomal, 18s–Genetics ; Young Adult–Genetics ; DNA, Ribosomal ; RNA, Ribosomal, 18s
descriptionBACKGROUNDPlasmodium knowlesi is a simian parasite that has been recognized as the fifth species causing human malaria. Naturally-acquired P. knowlesi infection is widespread among human populations in Southeast Asia. The aim of this epidemiological study was to determine the incidence and distribution of malaria parasites, with a particular focus on human P. knowlesi infection in Malaysia. METHODSA total of 457 microscopically confirmed, malaria-positive blood samples were collected from 22 state and main district hospitals in Malaysia between September 2012 and December 2013. Nested PCR assay targeting the 18S rRNA gene was used to determine the infecting Plasmodium species. RESULTSA total of 453 samples were positive for Plasmodium species by using nested PCR assay. Plasmodium knowlesi was identified in 256 (56.5%) samples, followed by 133 (29.4%) cases of Plasmodium vivax, 49 (10.8%) cases of Plasmodium falciparum, two (0.4%) cases of Plasmodium ovale and one (0.2%) case of Plasmodium malariae. Twelve mixed infections were detected, including P. knowlesi/P. vivax (n = 10), P. knowlesi/P. falciparum (n = 1), and P. falciparum/P. vivax (n = 1). Notably, P. knowlesi (Included mixed infections involving P. knowlesi (P. knowlesi/P. vivax and P. knowlesi /P. falciparum)) showed the highest proportion in Sabah (84/115 cases, prevalence of 73.0%), Sarawak (83/120, 69.2%), Kelantan (42/56, 75.0%), Pahang (24/25, 96.0%), Johor (7/9, 77.8%), and Terengganu (4/5, 80.0%,). In contrast, the rates of P. knowlesi infection in Selangor and Negeri Sembilan were found to be 16.2% (18/111 cases) and 50.0% (5/10 cases), respectively. Sample of P. knowlesi was not obtained from Kuala Lumpur, Melaka, Perak, Pulau Pinang, and Perlis during the study period, while a microscopically-positive sample from Kedah was negative by PCR. CONCLUSIONIn addition to Sabah and Sarawak, which have been known for high prevalence of P. knowlesi infection, the findings from this study highlight the widespread distribution of P. knowlesi in many Peninsular Malaysia states.
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titleHigh proportion of knowlesi malaria in recent malaria cases in Malaysia.
descriptionBACKGROUNDPlasmodium knowlesi is a simian parasite that has been recognized as the fifth species causing human malaria. Naturally-acquired P. knowlesi infection is widespread among human populations in Southeast Asia. The aim of this epidemiological study was to determine the incidence and distribution of malaria parasites, with a particular focus on human P. knowlesi infection in Malaysia. METHODSA total of 457 microscopically confirmed, malaria-positive blood samples were collected from 22 state and main district hospitals in Malaysia between September 2012 and December 2013. Nested PCR assay targeting the 18S rRNA gene was used to determine the infecting Plasmodium species. RESULTSA total of 453 samples were positive for Plasmodium species by using nested PCR assay. Plasmodium knowlesi was identified in 256 (56.5%) samples, followed by 133 (29.4%) cases of Plasmodium vivax, 49 (10.8%) cases of Plasmodium falciparum, two (0.4%) cases of Plasmodium ovale and one (0.2%) case of Plasmodium malariae. Twelve mixed infections were detected, including P. knowlesi/P. vivax (n = 10), P. knowlesi/P. falciparum (n = 1), and P. falciparum/P. vivax (n = 1). Notably, P. knowlesi (Included mixed infections involving P. knowlesi (P. knowlesi/P. vivax and P. knowlesi /P. falciparum)) showed the highest proportion in Sabah (84/115 cases, prevalence of 73.0%), Sarawak (83/120, 69.2%), Kelantan (42/56, 75.0%), Pahang (24/25, 96.0%), Johor (7/9, 77.8%), and Terengganu (4/5, 80.0%,). In contrast, the rates of P. knowlesi infection in Selangor and Negeri Sembilan were found to be 16.2% (18/111 cases) and 50.0% (5/10 cases), respectively. Sample of P. knowlesi was not obtained from Kuala Lumpur, Melaka, Perak, Pulau Pinang, and Perlis during the study period, while a microscopically-positive sample from Kedah was negative by PCR. CONCLUSIONIn addition to Sabah and Sarawak, which have been known for high prevalence of P. knowlesi infection, the findings from this study highlight the widespread distribution of P. knowlesi in many Peninsular Malaysia states.
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authorYusof, Ruhani ; Lau, Yee Ling ; Mahmud, Rohela ; Fong, Mun Yik ; Jelip, Jenarun ; Ngian, Hie Ung ; Mustakim, Sahlawati ; Hussin, Hani Mat ; Marzuki, Noradilah ; Mohd Ali, Marlindawati
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6DNA, Ribosomal–Isolation & Purification
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8Humans–Genetics
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10Infant–Genetics
11Infant, Newborn–Genetics
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13Malaysia–Genetics
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abstractBACKGROUNDPlasmodium knowlesi is a simian parasite that has been recognized as the fifth species causing human malaria. Naturally-acquired P. knowlesi infection is widespread among human populations in Southeast Asia. The aim of this epidemiological study was to determine the incidence and distribution of malaria parasites, with a particular focus on human P. knowlesi infection in Malaysia. METHODSA total of 457 microscopically confirmed, malaria-positive blood samples were collected from 22 state and main district hospitals in Malaysia between September 2012 and December 2013. Nested PCR assay targeting the 18S rRNA gene was used to determine the infecting Plasmodium species. RESULTSA total of 453 samples were positive for Plasmodium species by using nested PCR assay. Plasmodium knowlesi was identified in 256 (56.5%) samples, followed by 133 (29.4%) cases of Plasmodium vivax, 49 (10.8%) cases of Plasmodium falciparum, two (0.4%) cases of Plasmodium ovale and one (0.2%) case of Plasmodium malariae. Twelve mixed infections were detected, including P. knowlesi/P. vivax (n = 10), P. knowlesi/P. falciparum (n = 1), and P. falciparum/P. vivax (n = 1). Notably, P. knowlesi (Included mixed infections involving P. knowlesi (P. knowlesi/P. vivax and P. knowlesi /P. falciparum)) showed the highest proportion in Sabah (84/115 cases, prevalence of 73.0%), Sarawak (83/120, 69.2%), Kelantan (42/56, 75.0%), Pahang (24/25, 96.0%), Johor (7/9, 77.8%), and Terengganu (4/5, 80.0%,). In contrast, the rates of P. knowlesi infection in Selangor and Negeri Sembilan were found to be 16.2% (18/111 cases) and 50.0% (5/10 cases), respectively. Sample of P. knowlesi was not obtained from Kuala Lumpur, Melaka, Perak, Pulau Pinang, and Perlis during the study period, while a microscopically-positive sample from Kedah was negative by PCR. CONCLUSIONIn addition to Sabah and Sarawak, which have been known for high prevalence of P. knowlesi infection, the findings from this study highlight the widespread distribution of P. knowlesi in many Peninsular Malaysia states.
doi10.1186/1475-2875-13-168
urlhttp://search.proquest.com/docview/1532942367/
issue1
date2014-05-03