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The Effects of the Mediterranean Diet on Biomarkers of Vascular Wall Inflammation and Plaque Vulnerability in Subjects with High Risk for Cardiovascular Disease. A Randomized Trial

Background Adherence to the Mediterranean diet (MD) is associated with reduced morbidity and mortality due to cardiovascular disease. However, how the MD exerts its effects is not fully known. Aim To assess the 12-month effects of two enhanced MDs compared to a low-fat diet on inflammatory biomarker... Full description

Journal Title: PLoS One Jun 2014, Vol.9(6), p.e100084
Main Author: Casas, Rosa
Other Authors: Sacanella, Emilio , Urpí-Sardà, Mireia , Chiva-Blanch, Gemma , Ros, Emilio , Martínez-González, Miguel-Angel , Salas-Salvadó, Jordi , Fiol, Miquel , Arós, Fernando , Estruch, Ramon
Format: Electronic Article Electronic Article
Language: English
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ID: E-ISSN: 19326203 ; DOI: 10.1371/journal.pone.0100084
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title: The Effects of the Mediterranean Diet on Biomarkers of Vascular Wall Inflammation and Plaque Vulnerability in Subjects with High Risk for Cardiovascular Disease. A Randomized Trial
format: Article
creator:
  • Casas, Rosa
  • Sacanella, Emilio
  • Urpí-Sardà, Mireia
  • Chiva-Blanch, Gemma
  • Ros, Emilio
  • Martínez-González, Miguel-Angel
  • Salas-Salvadó, Jordi
  • Fiol, Miquel
  • Arós, Fernando
  • Estruch, Ramon
subjects:
  • Spain
  • Atherosclerosis
  • Lipoproteins (Low Density)
  • Nutrition Research
  • Mortality
  • Intervention
  • Patients
  • Cardiovascular Diseases
  • Cytokines
  • Ischemia
  • Cholesterol
  • Hospitals
  • Diet
  • Atherosclerosis
  • Risk Analysis
  • Interleukin 6
  • Blood Pressure
  • Cd40 Antigen
  • C-Reactive Protein
  • Arteriosclerosis
  • Cell Adhesion & Migration
  • Health Care
  • Blood Pressure
  • Health Risk Assessment
  • Risk Factors
  • Metabolic Syndrome
  • Alcohol
  • Heart
  • Randomization
  • Stability
  • Cholesterol
  • Preventive Medicine
  • Olive Oil
  • Health Risks
  • Clinical Trials
  • Diabetes
  • Food Science
  • Reduction
  • Cholesterol
  • Morbidity
  • Disease Control
  • Heart Diseases
  • Internal Medicine
  • Fats and Oils
  • Cholesterol
  • Lipids
  • P-Selectin
  • Inflammation
  • Bioindicators
  • Pharmacy
  • Heart Attacks
  • Blood Pressure
  • Hypertension
  • Cardiovascular Diseases
  • Nuts
  • Interleukin
  • Cardiovascular Disease
  • Clinical Trials
  • Biomarkers
  • Biomarkers
  • Olive Oil
  • Risk Factors
  • Systematic Review
  • Monocytes
  • Coronary Artery Disease
  • University of Barcelona
  • Diet
  • Vegetable Oils
  • Inflammation
  • Cardiovascular Diseases
  • Monocytes
  • Biomarkers
  • Atherosclerosis
  • Diet and Type 2 Diabetes
ispartof: PLoS One, Jun 2014, Vol.9(6), p.e100084
description: Background Adherence to the Mediterranean diet (MD) is associated with reduced morbidity and mortality due to cardiovascular disease. However, how the MD exerts its effects is not fully known. Aim To assess the 12-month effects of two enhanced MDs compared to a low-fat diet on inflammatory biomarkers related to atherosclerosis and plaque vulnerability in a subcohort of the PREDIMED (Prevención con Dieta Mediterránea) study. Methods A total of 164 participants at high risk for cardiovascular disease were randomized into three diet groups: MD supplemented with 50 mL/d of extra virgin olive oil (MD+EVOO) or 30 g/d of nuts (MD+Nuts) and a low-fat diet. Changes in classical cardiovascular risk factors, inflammatory biomarkers of atherosclerosis and plaque vulnerability were measured after 12 months of intervention. Results Compared to participants in the low-fat diet group, those receiving MD+EVOO and MD+Nuts showed a higher decrease in systolic (6 mmHg) and diastolic (3 mmHg) blood pressure (P = 0.02; both), as well as a reduction of 10% and 8% in LDL-cholesterol (P = 0.04), respectively. Patients in the MD+Nuts group showed a significant reduction of 34% in CD40 expression on monocyte surface compared to low-fat diet patients (P = 0.03). In addition, inflammatory biomarkers related to plaque instability such as C-reactive protein and interleukin-6 were reduced by 45% and 35% and 95% and 90% in the MD+EVOO and MD+Nuts groups, respectively (P
language: eng
source:
identifier: E-ISSN: 19326203 ; DOI: 10.1371/journal.pone.0100084
fulltext: fulltext_linktorsrc
issn:
  • 19326203
  • 1932-6203
url: Link


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titleThe Effects of the Mediterranean Diet on Biomarkers of Vascular Wall Inflammation and Plaque Vulnerability in Subjects with High Risk for Cardiovascular Disease. A Randomized Trial
creatorCasas, Rosa ; Sacanella, Emilio ; Urpí-Sardà, Mireia ; Chiva-Blanch, Gemma ; Ros, Emilio ; Martínez-González, Miguel-Angel ; Salas-Salvadó, Jordi ; Fiol, Miquel ; Arós, Fernando ; Estruch, Ramon
ispartofPLoS One, Jun 2014, Vol.9(6), p.e100084
identifierE-ISSN: 19326203 ; DOI: 10.1371/journal.pone.0100084
subjectSpain ; Atherosclerosis ; Lipoproteins (Low Density) ; Nutrition Research ; Mortality ; Intervention ; Patients ; Cardiovascular Diseases ; Cytokines ; Ischemia ; Cholesterol ; Hospitals ; Diet ; Atherosclerosis ; Risk Analysis ; Interleukin 6 ; Blood Pressure ; Cd40 Antigen ; C-Reactive Protein ; Arteriosclerosis ; Cell Adhesion & Migration ; Health Care ; Blood Pressure ; Health Risk Assessment ; Risk Factors ; Metabolic Syndrome ; Alcohol ; Heart ; Randomization ; Stability ; Cholesterol ; Preventive Medicine ; Olive Oil ; Health Risks ; Clinical Trials ; Diabetes ; Food Science ; Reduction ; Cholesterol ; Morbidity ; Disease Control ; Heart Diseases ; Internal Medicine ; Fats and Oils ; Cholesterol ; Lipids ; P-Selectin ; Inflammation ; Bioindicators ; Pharmacy ; Heart Attacks ; Blood Pressure ; Hypertension ; Cardiovascular Diseases ; Nuts ; Interleukin ; Cardiovascular Disease ; Clinical Trials ; Biomarkers ; Biomarkers ; Olive Oil ; Risk Factors ; Systematic Review ; Monocytes ; Coronary Artery Disease ; University of Barcelona ; Diet ; Vegetable Oils ; Inflammation ; Cardiovascular Diseases ; Monocytes ; Biomarkers ; Atherosclerosis ; Diet and Type 2 Diabetes
descriptionBackground Adherence to the Mediterranean diet (MD) is associated with reduced morbidity and mortality due to cardiovascular disease. However, how the MD exerts its effects is not fully known. Aim To assess the 12-month effects of two enhanced MDs compared to a low-fat diet on inflammatory biomarkers related to atherosclerosis and plaque vulnerability in a subcohort of the PREDIMED (Prevención con Dieta Mediterránea) study. Methods A total of 164 participants at high risk for cardiovascular disease were randomized into three diet groups: MD supplemented with 50 mL/d of extra virgin olive oil (MD+EVOO) or 30 g/d of nuts (MD+Nuts) and a low-fat diet. Changes in classical cardiovascular risk factors, inflammatory biomarkers of atherosclerosis and plaque vulnerability were measured after 12 months of intervention. Results Compared to participants in the low-fat diet group, those receiving MD+EVOO and MD+Nuts showed a higher decrease in systolic (6 mmHg) and diastolic (3 mmHg) blood pressure (P = 0.02; both), as well as a reduction of 10% and 8% in LDL-cholesterol (P = 0.04), respectively. Patients in the MD+Nuts group showed a significant reduction of 34% in CD40 expression on monocyte surface compared to low-fat diet patients (P = 0.03). In addition, inflammatory biomarkers related to plaque instability such as C-reactive protein and interleukin-6 were reduced by 45% and 35% and 95% and 90% in the MD+EVOO and MD+Nuts groups, respectively (P<0.05; all) compared to the low-fat diet group. Likewise, sICAM and P-selectin were also reduced by 50% and 27%, respectively in the MD+EVOO group (P = 0.04) and P-selectin by 19% in MD+Nuts group (P = 0.04) compared to the low-fat diet group. Conclusions Adherence to the MD is associated with an increase in serum markers of atheroma plaque stability which may explain, at least in part, the protective role of MD against ischemic heart disease. Trial Registration www.controlled-trials.com ISRCTN35739639
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1Sacanella, Emilio
2Urpí-Sardà, Mireia
3Chiva-Blanch, Gemma
4Ros, Emilio
5Martínez-González, Miguel-Angel
6Salas-Salvadó, Jordi
7Fiol, Miquel
8Arós, Fernando
9Estruch, Ramon
titleThe Effects of the Mediterranean Diet on Biomarkers of Vascular Wall Inflammation and Plaque Vulnerability in Subjects with High Risk for Cardiovascular Disease. A Randomized Trial
descriptionBackground Adherence to the Mediterranean diet (MD) is associated with reduced morbidity and mortality due to cardiovascular disease. However, how the MD exerts its effects is not fully known. Aim To assess the 12-month effects of two enhanced MDs compared to a low-fat diet on inflammatory biomarkers related to atherosclerosis and plaque vulnerability in a subcohort of the PREDIMED (Prevención con Dieta Mediterránea) study. Methods A total of 164 participants at high risk for cardiovascular disease were randomized into three diet groups: MD supplemented with 50 mL/d of extra virgin olive oil (MD+EVOO) or 30 g/d of nuts (MD+Nuts) and a low-fat diet. Changes in classical cardiovascular risk factors, inflammatory biomarkers of atherosclerosis and plaque vulnerability were measured after 12 months of intervention. Results Compared to participants in the low-fat diet group, those receiving MD+EVOO and MD+Nuts showed a higher decrease in systolic (6 mmHg) and diastolic (3 mmHg) blood pressure (P = 0.02; both), as well as a reduction of 10% and 8% in LDL-cholesterol (P = 0.04), respectively. Patients in the MD+Nuts group showed a significant reduction of 34% in CD40 expression on monocyte surface compared to low-fat diet patients (P = 0.03). In addition, inflammatory biomarkers related to plaque instability such as C-reactive protein and interleukin-6 were reduced by 45% and 35% and 95% and 90% in the MD+EVOO and MD+Nuts groups, respectively (P<0.05; all) compared to the low-fat diet group. Likewise, sICAM and P-selectin were also reduced by 50% and 27%, respectively in the MD+EVOO group (P = 0.04) and P-selectin by 19% in MD+Nuts group (P = 0.04) compared to the low-fat diet group. Conclusions Adherence to the MD is associated with an increase in serum markers of atheroma plaque stability which may explain, at least in part, the protective role of MD against ischemic heart disease. Trial Registration www.controlled-trials.com ISRCTN35739639
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12Diet
13Risk Analysis
14Interleukin 6
15Blood Pressure
16Cd40 Antigen
17C-Reactive Protein
18Arteriosclerosis
19Cell Adhesion & Migration
20Health Care
21Health Risk Assessment
22Risk Factors
23Metabolic Syndrome
24Alcohol
25Heart
26Randomization
27Stability
28Preventive Medicine
29Olive Oil
30Health Risks
31Clinical Trials
32Diabetes
33Food Science
34Reduction
35Morbidity
36Disease Control
37Heart Diseases
38Internal Medicine
39Fats and Oils
40Lipids
41P-Selectin
42Inflammation
43Bioindicators
44Pharmacy
45Heart Attacks
46Hypertension
47Nuts
48Interleukin
49Cardiovascular Disease
50Biomarkers
51Systematic Review
52Monocytes
53Coronary Artery Disease
54University of Barcelona
55Vegetable Oils
56Diet and Type 2 Diabetes
57611310
58Vegetable oils
59Cardiovascular diseases
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citationpf e100084 vol 9 issue 6
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titleThe Effects of the Mediterranean Diet on Biomarkers of Vascular Wall Inflammation and Plaque Vulnerability in Subjects with High Risk for Cardiovascular Disease. A Randomized Trial
authorCasas, Rosa ; Sacanella, Emilio ; Urpí-Sardà, Mireia ; Chiva-Blanch, Gemma ; Ros, Emilio ; Martínez-González, Miguel-Angel ; Salas-Salvadó, Jordi ; Fiol, Miquel ; Arós, Fernando ; Estruch, Ramon
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0Spain
1Atherosclerosis
2Lipoproteins (Low Density)
3Nutrition Research
4Mortality
5Intervention
6Patients
7Cardiovascular Diseases
8Cytokines
9Ischemia
10Cholesterol
11Hospitals
12Diet
13Risk Analysis
14Interleukin 6
15Blood Pressure
16Cd40 Antigen
17C-Reactive Protein
18Arteriosclerosis
19Cell Adhesion & Migration
20Health Care
21Health Risk Assessment
22Risk Factors
23Metabolic Syndrome
24Alcohol
25Heart
26Randomization
27Stability
28Preventive Medicine
29Olive Oil
30Health Risks
31Clinical Trials
32Diabetes
33Food Science
34Reduction
35Morbidity
36Disease Control
37Heart Diseases
38Internal Medicine
39Fats and Oils
40Lipids
41P-Selectin
42Inflammation
43Bioindicators
44Pharmacy
45Heart Attacks
46Hypertension
47Nuts
48Interleukin
49Cardiovascular Disease
50Biomarkers
51Systematic Review
52Monocytes
53Coronary Artery Disease
54University of Barcelona
55Vegetable Oils
56Diet and Type 2 Diabetes
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1Sacanella, Emilio
2Urpí-Sardà, Mireia
3Chiva-Blanch, Gemma
4Ros, Emilio
5Martínez-González, Miguel-Angel
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atitleThe Effects of the Mediterranean Diet on Biomarkers of Vascular Wall Inflammation and Plaque Vulnerability in Subjects with High Risk for Cardiovascular Disease. A Randomized Trial
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abstractBackground Adherence to the Mediterranean diet (MD) is associated with reduced morbidity and mortality due to cardiovascular disease. However, how the MD exerts its effects is not fully known. Aim To assess the 12-month effects of two enhanced MDs compared to a low-fat diet on inflammatory biomarkers related to atherosclerosis and plaque vulnerability in a subcohort of the PREDIMED (Prevención con Dieta Mediterránea) study. Methods A total of 164 participants at high risk for cardiovascular disease were randomized into three diet groups: MD supplemented with 50 mL/d of extra virgin olive oil (MD+EVOO) or 30 g/d of nuts (MD+Nuts) and a low-fat diet. Changes in classical cardiovascular risk factors, inflammatory biomarkers of atherosclerosis and plaque vulnerability were measured after 12 months of intervention. Results Compared to participants in the low-fat diet group, those receiving MD+EVOO and MD+Nuts showed a higher decrease in systolic (6 mmHg) and diastolic (3 mmHg) blood pressure (P = 0.02; both), as well as a reduction of 10% and 8% in LDL-cholesterol (P = 0.04), respectively. Patients in the MD+Nuts group showed a significant reduction of 34% in CD40 expression on monocyte surface compared to low-fat diet patients (P = 0.03). In addition, inflammatory biomarkers related to plaque instability such as C-reactive protein and interleukin-6 were reduced by 45% and 35% and 95% and 90% in the MD+EVOO and MD+Nuts groups, respectively (P<0.05; all) compared to the low-fat diet group. Likewise, sICAM and P-selectin were also reduced by 50% and 27%, respectively in the MD+EVOO group (P = 0.04) and P-selectin by 19% in MD+Nuts group (P = 0.04) compared to the low-fat diet group. Conclusions Adherence to the MD is associated with an increase in serum markers of atheroma plaque stability which may explain, at least in part, the protective role of MD against ischemic heart disease. Trial Registration www.controlled-trials.com ISRCTN35739639
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