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Role of apolipoprotein AI gene polymorphism (G-75A and C+83T) in essential hypertension in Indian population.

Hypertension is becoming a public health emergency worldwide. It has been seen that both genetics and gene-environment interactions are major determinants of lipoprotein abnormalities and hypertension. This study elucidates the effect of apolipoprotein AI gene polymorphism (G-75A and C+83T) in 50 ca... Full description

Journal Title: Annals of clinical and laboratory science 2014, Vol.44(3), pp.298-303
Main Author: Sinha, Rupal
Other Authors: Singh, Ritu
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1550-8080
Link: http://search.proquest.com/docview/1553316478/?pq-origsite=primo
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recordid: proquest1553316478
title: Role of apolipoprotein AI gene polymorphism (G-75A and C+83T) in essential hypertension in Indian population.
format: Article
creator:
  • Sinha, Rupal
  • Singh, Ritu
subjects:
  • Adult–Genetics
  • Apolipoprotein A-I–Genetics
  • Essential Hypertension–Genetics
  • Female–Genetics
  • Genetic Predisposition to Disease–Genetics
  • Humans–Genetics
  • Hypertension–Genetics
  • India–Genetics
  • Male–Genetics
  • Middle Aged–Genetics
  • Polymorphism, Genetic–Genetics
  • Apoa1 Protein, Human
  • Apolipoprotein A-I
  • Essential Hypertension
  • Apolipoprotein A1
  • Gene Polymorphism
  • Gene-Environment Interactions
  • Obesity
ispartof: Annals of clinical and laboratory science, 2014, Vol.44(3), pp.298-303
description: Hypertension is becoming a public health emergency worldwide. It has been seen that both genetics and gene-environment interactions are major determinants of lipoprotein abnormalities and hypertension. This study elucidates the effect of apolipoprotein AI gene polymorphism (G-75A and C+83T) in 50 cases of essential hypertension and equal number of age & sex matched control subjects in the Indian population. Higher instances of obesity and more adverse biochemical profiles were found in hypertensives [GA (74%) and CT (56%) most commonly observed genotypes]. Presence of A and T alleles and GA (-75 bp) and CT (+83 bp) heterozygosity in apolipoprotein AI gene play an important role in essential hypertension (GA genotype had an odds ratio of 4.27 (1.69-10.96) of developing essential hypertension). The odds ratio for the GA genotype was 3.74 (95%CI, 0.83-9.0) in the presence of confounding factors including total proteins, albumin, amylase, cholesterol, triglycerides, LDL, VLDL and body mass index. It indicates one of the potential areas where population studies may be taken up for identifying the genetic basis of essential hypertension.
language: eng
source:
identifier: E-ISSN: 1550-8080
fulltext: fulltext
issn:
  • 15508080
  • 1550-8080
url: Link


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titleRole of apolipoprotein AI gene polymorphism (G-75A and C+83T) in essential hypertension in Indian population.
creatorSinha, Rupal ; Singh, Ritu
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ispartofAnnals of clinical and laboratory science, 2014, Vol.44(3), pp.298-303
identifierE-ISSN: 1550-8080
subjectAdult–Genetics ; Apolipoprotein A-I–Genetics ; Essential Hypertension–Genetics ; Female–Genetics ; Genetic Predisposition to Disease–Genetics ; Humans–Genetics ; Hypertension–Genetics ; India–Genetics ; Male–Genetics ; Middle Aged–Genetics ; Polymorphism, Genetic–Genetics ; Apoa1 Protein, Human ; Apolipoprotein A-I ; Essential Hypertension ; Apolipoprotein A1 ; Gene Polymorphism ; Gene-Environment Interactions ; Obesity
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descriptionHypertension is becoming a public health emergency worldwide. It has been seen that both genetics and gene-environment interactions are major determinants of lipoprotein abnormalities and hypertension. This study elucidates the effect of apolipoprotein AI gene polymorphism (G-75A and C+83T) in 50 cases of essential hypertension and equal number of age & sex matched control subjects in the Indian population. Higher instances of obesity and more adverse biochemical profiles were found in hypertensives [GA (74%) and CT (56%) most commonly observed genotypes]. Presence of A and T alleles and GA (-75 bp) and CT (+83 bp) heterozygosity in apolipoprotein AI gene play an important role in essential hypertension (GA genotype had an odds ratio of 4.27 (1.69-10.96) of developing essential hypertension). The odds ratio for the GA genotype was 3.74 (95%CI, 0.83-9.0) in the presence of confounding factors including total proteins, albumin, amylase, cholesterol, triglycerides, LDL, VLDL and body mass index. It indicates one of the potential areas where population studies may be taken up for identifying the genetic basis of essential hypertension.
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