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Histological lesions, cell cycle arrest, apoptosis and T cell subsets changes of spleen in chicken fed aflatoxin-contaminated corn.

The purpose of this study was to evaluate the effects of corn naturally contaminated with aflatoxin B1 and aflatoxin B2 on pathological lesions, apoptosis, cell cycle phases and T lymphocyte subsets of spleen, and to provide an experimental basis for understanding the mechanism of aflatoxin-induced... Full description

Journal Title: International journal of environmental research and public health August 20, 2014, Vol.11(8), pp.8567-8580
Main Author: Peng, Xi
Other Authors: Zhang, Keying , Bai, Shiping , Ding, Xuemei , Zeng, Qiufeng , Yang, Jun , Fang, Jing , Chen, Kejie
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1660-4601 ; DOI: 1660-4601 ; DOI: 10.3390/ijerph110808567
Link: http://search.proquest.com/docview/1555619792/?pq-origsite=primo
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title: Histological lesions, cell cycle arrest, apoptosis and T cell subsets changes of spleen in chicken fed aflatoxin-contaminated corn.
format: Article
creator:
  • Peng, Xi
  • Zhang, Keying
  • Bai, Shiping
  • Ding, Xuemei
  • Zeng, Qiufeng
  • Yang, Jun
  • Fang, Jing
  • Chen, Kejie
subjects:
  • Aflatoxin B1–Toxicity
  • Aflatoxins–Toxicity
  • Animal Feed–Analysis
  • Animals–Drug Effects
  • Apoptosis–Drug Effects
  • Cell Cycle–Veterinary
  • Chickens–Drug Effects
  • Diet–Immunology
  • Immune Tolerance–Pathology
  • Male–Drug Effects
  • Random Allocation–Microbiology
  • Spleen–Chemistry
  • T-Lymphocyte Subsets–Chemistry
  • Zea Mays–Chemistry
  • Aflatoxins
  • Aflatoxin B2
  • Aflatoxin B1
ispartof: International journal of environmental research and public health, August 20, 2014, Vol.11(8), pp.8567-8580
description: The purpose of this study was to evaluate the effects of corn naturally contaminated with aflatoxin B1 and aflatoxin B2 on pathological lesions, apoptosis, cell cycle phases and T lymphocyte subsets of spleen, and to provide an experimental basis for understanding the mechanism of aflatoxin-induced immunosuppression. A total of 900 COBB500 male broilers were randomly allocated into five groups with six replicates per group and 30 birds per replicate. The experiment lasted for 6 weeks and the five dietary treatments consisted of control, 25% contaminated corn, 50% contaminated corn, 75% contaminated corn and 100% contaminated corn groups. The histopathological spleen lesions from the contaminated corn groups was characterized as congestion of red pulp, increased necrotic cells and vacuoles in the splenic corpuscle and periarterial lymphatic sheath. The contaminated corn intake significantly increased relative weight of spleen, percentages of apoptotic splenocytes, induced cell cycle arrest of splenocytes, increased the percentages of CD3^sup +^CD8^sup +^ T cells and decreased the ratios of CD3^sup +^CD4^sup +^ to CD3^sup +^CD8^sup +^. The results suggest that AFB-induced immunosuppression maybe closely related to the lesions of spleen.
language: eng
source:
identifier: E-ISSN: 1660-4601 ; DOI: 1660-4601 ; DOI: 10.3390/ijerph110808567
fulltext: fulltext
issn:
  • 16604601
  • 1660-4601
url: Link


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titleHistological lesions, cell cycle arrest, apoptosis and T cell subsets changes of spleen in chicken fed aflatoxin-contaminated corn.
creatorPeng, Xi ; Zhang, Keying ; Bai, Shiping ; Ding, Xuemei ; Zeng, Qiufeng ; Yang, Jun ; Fang, Jing ; Chen, Kejie
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subjectAflatoxin B1–Toxicity ; Aflatoxins–Toxicity ; Animal Feed–Analysis ; Animals–Drug Effects ; Apoptosis–Drug Effects ; Cell Cycle–Veterinary ; Chickens–Drug Effects ; Diet–Immunology ; Immune Tolerance–Pathology ; Male–Drug Effects ; Random Allocation–Microbiology ; Spleen–Chemistry ; T-Lymphocyte Subsets–Chemistry ; Zea Mays–Chemistry ; Aflatoxins ; Aflatoxin B2 ; Aflatoxin B1
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descriptionThe purpose of this study was to evaluate the effects of corn naturally contaminated with aflatoxin B1 and aflatoxin B2 on pathological lesions, apoptosis, cell cycle phases and T lymphocyte subsets of spleen, and to provide an experimental basis for understanding the mechanism of aflatoxin-induced immunosuppression. A total of 900 COBB500 male broilers were randomly allocated into five groups with six replicates per group and 30 birds per replicate. The experiment lasted for 6 weeks and the five dietary treatments consisted of control, 25% contaminated corn, 50% contaminated corn, 75% contaminated corn and 100% contaminated corn groups. The histopathological spleen lesions from the contaminated corn groups was characterized as congestion of red pulp, increased necrotic cells and vacuoles in the splenic corpuscle and periarterial lymphatic sheath. The contaminated corn intake significantly increased relative weight of spleen, percentages of apoptotic splenocytes, induced cell cycle arrest of splenocytes, increased the percentages of CD3^sup +^CD8^sup +^ T cells and decreased the ratios of CD3^sup +^CD4^sup +^ to CD3^sup +^CD8^sup +^. The results suggest that AFB-induced immunosuppression maybe closely related to the lesions of spleen.
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