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Intramuscular distribution of botulinum toxin--visualized by MRI.

OBJECTIVEA precise knowledge of the spread of botulinum toxin (BoNT) in muscle tissue is required to efficiently access endplate zones and increase BoNT's therapeutic efficacy. Here, we aimed to understand the spatiotemporal dynamics of BoNT distribution in skeletal muscle and its modulating factors... Full description

Journal Title: Journal of the neurological sciences September 15, 2014, Vol.344(1-2), pp.76-79
Main Author: Elwischger, K
Other Authors: Kasprian, G , Weber, M , Meyerspeer, M , Linder, C , Auff, E , Prayer, D , Sycha, T , Kranz, G
Format: Electronic Article Electronic Article
Language: English
Subjects:
Mri
ID: E-ISSN: 1878-5883 ; DOI: 10.1016/j.jns.2014.06.028
Link: http://search.proquest.com/docview/1555627939/?pq-origsite=primo
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title: Intramuscular distribution of botulinum toxin--visualized by MRI.
format: Article
creator:
  • Elwischger, K
  • Kasprian, G
  • Weber, M
  • Meyerspeer, M
  • Linder, C
  • Auff, E
  • Prayer, D
  • Sycha, T
  • Kranz, G
subjects:
  • Adult–Metabolism
  • Aged–Therapeutic Use
  • Botulinum Toxins–Drug Effects
  • Diffusion Tensor Imaging–Metabolism
  • Female–Metabolism
  • Humans–Therapeutic Use
  • Injections, Intramuscular–Drug Therapy
  • Magnetic Resonance Imaging–Pathology
  • Male–Pathology
  • Middle Aged–Pathology
  • Muscle, Skeletal–Pathology
  • Neurotoxins–Pathology
  • Spasm–Pathology
  • Young Adult–Pathology
  • Neurotoxins
  • Botulinum Toxins
  • Botulinum Toxin
  • Distribution
  • Mri
  • Spasticity
ispartof: Journal of the neurological sciences, September 15, 2014, Vol.344(1-2), pp.76-79
description: OBJECTIVEA precise knowledge of the spread of botulinum toxin (BoNT) in muscle tissue is required to efficiently access endplate zones and increase BoNT's therapeutic efficacy. Here, we aimed to understand the spatiotemporal dynamics of BoNT distribution in skeletal muscle and its modulating factors, such as injected volume and exercise after injection. METHODSTo visualize distribution in muscle tissue, sagittal, dynamic, balanced fast field echo (BFFE) MRI imaging was performed during injection of 1 ml BoNT/NaCl bolus in spastic biceps brachii muscles (SBB, n=4), and 1 ml NaCl in the right and 2 ml NaCl in the left healthy biceps brachii (HBB, n=6), with or without successive muscle exercise. The pattern of extracellular fluid distribution was evaluated by T2-weighted and diffusion tensor imaging (DTI) sequences. RESULTSBFFE indicated an immediate increase in hyperintensity, parallel to the muscle fibers, in the shape of a long (5.3±1.7 cm) and thin (0.52±1.3 cm) layer in HBB. The layer...
language: eng
source:
identifier: E-ISSN: 1878-5883 ; DOI: 10.1016/j.jns.2014.06.028
fulltext: fulltext
issn:
  • 18785883
  • 1878-5883
url: Link


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titleIntramuscular distribution of botulinum toxin--visualized by MRI.
creatorElwischger, K ; Kasprian, G ; Weber, M ; Meyerspeer, M ; Linder, C ; Auff, E ; Prayer, D ; Sycha, T ; Kranz, G
contributorElwischger, K (correspondence author) ; Elwischger, K (record owner)
ispartofJournal of the neurological sciences, September 15, 2014, Vol.344(1-2), pp.76-79
identifierE-ISSN: 1878-5883 ; DOI: 10.1016/j.jns.2014.06.028
subjectAdult–Metabolism ; Aged–Therapeutic Use ; Botulinum Toxins–Drug Effects ; Diffusion Tensor Imaging–Metabolism ; Female–Metabolism ; Humans–Therapeutic Use ; Injections, Intramuscular–Drug Therapy ; Magnetic Resonance Imaging–Pathology ; Male–Pathology ; Middle Aged–Pathology ; Muscle, Skeletal–Pathology ; Neurotoxins–Pathology ; Spasm–Pathology ; Young Adult–Pathology ; Neurotoxins ; Botulinum Toxins ; Botulinum Toxin ; Distribution ; Mri ; Spasticity
descriptionOBJECTIVEA precise knowledge of the spread of botulinum toxin (BoNT) in muscle tissue is required to efficiently access endplate zones and increase BoNT's therapeutic efficacy. Here, we aimed to understand the spatiotemporal dynamics of BoNT distribution in skeletal muscle and its modulating factors, such as injected volume and exercise after injection. METHODSTo visualize distribution in muscle tissue, sagittal, dynamic, balanced fast field echo (BFFE) MRI imaging was performed during injection of 1 ml BoNT/NaCl bolus in spastic biceps brachii muscles (SBB, n=4), and 1 ml NaCl in the right and 2 ml NaCl in the left healthy biceps brachii (HBB, n=6), with or without successive muscle exercise. The pattern of extracellular fluid distribution was evaluated by T2-weighted and diffusion tensor imaging (DTI) sequences. RESULTSBFFE indicated an immediate increase in hyperintensity, parallel to the muscle fibers, in the shape of a long (5.3±1.7 cm) and thin (0.52±1.3 cm) layer in HBB. The layer...
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titleIntramuscular distribution of botulinum toxin--visualized by MRI.
descriptionOBJECTIVEA precise knowledge of the spread of botulinum toxin (BoNT) in muscle tissue is required to efficiently access endplate zones and increase BoNT's therapeutic efficacy. Here, we aimed to understand the spatiotemporal dynamics of BoNT distribution in skeletal muscle and its modulating factors, such as injected volume and exercise after injection. METHODSTo visualize distribution in muscle tissue, sagittal, dynamic, balanced fast field echo (BFFE) MRI imaging was performed during injection of 1 ml BoNT/NaCl bolus in spastic biceps brachii muscles (SBB, n=4), and 1 ml NaCl in the right and 2 ml NaCl in the left healthy biceps brachii (HBB, n=6), with or without successive muscle exercise. The pattern of extracellular fluid distribution was evaluated by T2-weighted and diffusion tensor imaging (DTI) sequences. RESULTSBFFE indicated an immediate increase in hyperintensity, parallel to the muscle fibers, in the shape of a long (5.3±1.7 cm) and thin (0.52±1.3 cm) layer in HBB. The layer...
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titleIntramuscular distribution of botulinum toxin--visualized by MRI.
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abstractOBJECTIVEA precise knowledge of the spread of botulinum toxin (BoNT) in muscle tissue is required to efficiently access endplate zones and increase BoNT's therapeutic efficacy. Here, we aimed to understand the spatiotemporal dynamics of BoNT distribution in skeletal muscle and its modulating factors, such as injected volume and exercise after injection. METHODSTo visualize distribution in muscle tissue, sagittal, dynamic, balanced fast field echo (BFFE) MRI imaging was performed during injection of 1 ml BoNT/NaCl bolus in spastic biceps brachii muscles (SBB, n=4), and 1 ml NaCl in the right and 2 ml NaCl in the left healthy biceps brachii (HBB, n=6), with or without successive muscle exercise. The pattern of extracellular fluid distribution was evaluated by T2-weighted and diffusion tensor imaging (DTI) sequences. RESULTSBFFE indicated an immediate increase in hyperintensity, parallel to the muscle fibers, in the shape of a long (5.3±1.7 cm) and thin (0.52±1.3 cm) layer in HBB. The layer...
doi10.1016/j.jns.2014.06.028
urlhttp://search.proquest.com/docview/1555627939/
issn0022510X
date2014-09-15