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Subjective cognitive complaints contribute to misdiagnosis of mild cognitive impairment.

Abstract Subjective cognitive complaints are a criterion for the diagnosis of mild cognitive impairment (MCI), despite their uncertain relationship to objective memory performance in MCI. We aimed to examine self-reported cognitive complaints in subgroups of the Alzheimer’s Disease Neuroimaging Init... Full description

Journal Title: Journal of the International Neuropsychological Society : JINS September 2014, Vol.20(8), pp.836-847
Main Author: Edmonds, Emily C
Other Authors: Delano-Wood, Lisa , Galasko, Douglas R , Salmon, David P , Bondi, Mark W , Edmonds, Emily C
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1469-7661 ; DOI: 10.1017/S135561771400068X
Link: http://search.proquest.com/docview/1564354784/?pq-origsite=primo
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title: Subjective cognitive complaints contribute to misdiagnosis of mild cognitive impairment.
format: Article
creator:
  • Edmonds, Emily C
  • Delano-Wood, Lisa
  • Galasko, Douglas R
  • Salmon, David P
  • Bondi, Mark W
  • Edmonds, Emily C
subjects:
  • Aged–Cerebrospinal Fluid
  • Aged, 80 and Over–Cerebrospinal Fluid
  • Amyloid Beta-Peptides–Diagnosis
  • Analysis of Variance–Psychology
  • Attention–Cerebrospinal Fluid
  • Cognitive Dysfunction–Cerebrospinal Fluid
  • Diagnostic Errors–Cerebrospinal Fluid
  • Discriminant Analysis–Cerebrospinal Fluid
  • Female–Cerebrospinal Fluid
  • Humans–Cerebrospinal Fluid
  • Language–Cerebrospinal Fluid
  • Male–Cerebrospinal Fluid
  • Middle Aged–Cerebrospinal Fluid
  • Neuropsychological Tests–Cerebrospinal Fluid
  • Peptide Fragments–Cerebrospinal Fluid
  • Self Report–Cerebrospinal Fluid
  • Surveys and Questionnaires–Cerebrospinal Fluid
  • Tau Proteins–Cerebrospinal Fluid
  • Amyloid Beta-Peptides
  • Peptide Fragments
ispartof: Journal of the International Neuropsychological Society : JINS, September 2014, Vol.20(8), pp.836-847
description: Abstract Subjective cognitive complaints are a criterion for the diagnosis of mild cognitive impairment (MCI), despite their uncertain relationship to objective memory performance in MCI. We aimed to examine self-reported cognitive complaints in subgroups of the Alzheimer’s Disease Neuroimaging Initiative (ADNI) MCI cohort to determine whether they are a valuable inclusion in the diagnosis of MCI or, alternatively, if they contribute to misdiagnosis. Subgroups of MCI were derived using cluster analysis of baseline neuropsychological test data from 448 ADNI MCI participants. Cognitive complaints were assessed via the Everyday Cognition (ECog) questionnaire, and discrepancy scores were calculated between self- and informant-report. Cluster analysis revealed Amnestic and Mixed cognitive phenotypes as well as a third Cluster-Derived Normal subgroup (41.3%), whose neuropsychological and cerebrospinal fluid (CSF) Alzheimer’s disease (AD) biomarker profiles did not differ from a “robust” normal control group. This cognitively intact phenotype of MCI participants overestimated their cognitive problems relative to their informant, whereas Amnestic MCI participants with objective memory impairment underestimated their cognitive problems. Underestimation of cognitive problems was associated with positive CSF AD biomarkers and progression to dementia. Overall, there was no relationship between self-reported cognitive complaints and objective cognitive functioning, but significant correlations were observed with depressive symptoms. The inclusion of self-reported complaints in MCI diagnostic criteria may cloud rather than clarify diagnosis and result in high rates of misclassification of MCI. Discrepancies between self- and informant-report demonstrate that overestimation of cognitive problems is characteristic of normal aging while underestimation may reflect greater risk for cognitive decline. ( JINS , 2014, 20 , 1–12)
language: eng
source:
identifier: E-ISSN: 1469-7661 ; DOI: 10.1017/S135561771400068X
fulltext: fulltext
issn:
  • 14697661
  • 1469-7661
url: Link


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titleSubjective cognitive complaints contribute to misdiagnosis of mild cognitive impairment.
creatorEdmonds, Emily C ; Delano-Wood, Lisa ; Galasko, Douglas R ; Salmon, David P ; Bondi, Mark W ; Edmonds, Emily C
contributorWeiner, Michael W (correspondence author) ; Aisen, Paul (record owner) ; Petersen, Ronald ; Jack, Clifford R ; Jagust, William ; Trojanowki, John Q ; Toga, Arthur W ; Beckett, Laurel ; Green, Robert C ; Saykin, Andrew J ; Morris, John ; Shaw, Leslie M ; Khachaturian, Zaven ; Sorensen, Greg ; Carrillo, Maria ; Kuller, Lew ; Raichle, Marc ; Paul, Steven ; Davies, Peter ; Fillit
ispartofJournal of the International Neuropsychological Society : JINS, September 2014, Vol.20(8), pp.836-847
identifierE-ISSN: 1469-7661 ; DOI: 10.1017/S135561771400068X
subjectAged–Cerebrospinal Fluid ; Aged, 80 and Over–Cerebrospinal Fluid ; Amyloid Beta-Peptides–Diagnosis ; Analysis of Variance–Psychology ; Attention–Cerebrospinal Fluid ; Cognitive Dysfunction–Cerebrospinal Fluid ; Diagnostic Errors–Cerebrospinal Fluid ; Discriminant Analysis–Cerebrospinal Fluid ; Female–Cerebrospinal Fluid ; Humans–Cerebrospinal Fluid ; Language–Cerebrospinal Fluid ; Male–Cerebrospinal Fluid ; Middle Aged–Cerebrospinal Fluid ; Neuropsychological Tests–Cerebrospinal Fluid ; Peptide Fragments–Cerebrospinal Fluid ; Self Report–Cerebrospinal Fluid ; Surveys and Questionnaires–Cerebrospinal Fluid ; Tau Proteins–Cerebrospinal Fluid ; Amyloid Beta-Peptides ; Peptide Fragments
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descriptionAbstract Subjective cognitive complaints are a criterion for the diagnosis of mild cognitive impairment (MCI), despite their uncertain relationship to objective memory performance in MCI. We aimed to examine self-reported cognitive complaints in subgroups of the Alzheimer’s Disease Neuroimaging Initiative (ADNI) MCI cohort to determine whether they are a valuable inclusion in the diagnosis of MCI or, alternatively, if they contribute to misdiagnosis. Subgroups of MCI were derived using cluster analysis of baseline neuropsychological test data from 448 ADNI MCI participants. Cognitive complaints were assessed via the Everyday Cognition (ECog) questionnaire, and discrepancy scores were calculated between self- and informant-report. Cluster analysis revealed Amnestic and Mixed cognitive phenotypes as well as a third Cluster-Derived Normal subgroup (41.3%), whose neuropsychological and cerebrospinal fluid (CSF) Alzheimer’s disease (AD) biomarker profiles did not differ from a “robust” normal control group. This cognitively intact phenotype of MCI participants overestimated their cognitive problems relative to their informant, whereas Amnestic MCI participants with objective memory impairment underestimated their cognitive problems. Underestimation of cognitive problems was associated with positive CSF AD biomarkers and progression to dementia. Overall, there was no relationship between self-reported cognitive complaints and objective cognitive functioning, but significant correlations were observed with depressive symptoms. The inclusion of self-reported complaints in MCI diagnostic criteria may cloud rather than clarify diagnosis and result in high rates of misclassification of MCI. Discrepancies between self- and informant-report demonstrate that overestimation of cognitive problems is characteristic of normal aging while underestimation may reflect greater risk for cognitive decline. ( JINS , 2014, 20 , 1–12)
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2Petersen, Ronald
3Jack, Clifford R
4Jagust, William
5Trojanowki, John Q
6Toga, Arthur W
7Beckett, Laurel
8Green, Robert C
9Saykin, Andrew J
10Morris, John
11Shaw, Leslie M
12Khachaturian, Zaven
13Sorensen, Greg
14Carrillo, Maria
15Kuller, Lew
16Raichle, Marc
17Paul, Steven
18Davies, Peter
19Fillit, Howard
20Hefti, Franz
21Holtzman, Davie
22Mesulam, M Marcel
23Potter, William
24Snyder, Peter
25Schwartz, Adam
26Montine, Tom
27Thomas, Ronald G
28Donohue, Michael
29Walter, Sarah
30Gessert, Devon
31Sather, Tamie
32Jiminez, Gus
33Harvey, Danielle
34Bernstein, Matthew
35Fox, Nick
36Thompson, Paul
37Schuff, Norbert
38Decarli, Charles
39Borowski, Bret
40Gunter, Jeff
41Senjem, Matt
42Vemuri, Prashanthi
43Jones, David
44Kantarci, Kejal
45Ward, Chad
46Koeppe, Robert A
47Foster, Norm
48Reiman, Eric M
49Chen, Kewei
50Mathis, Chet
51Landau, Susan
52Morris, John C
53Cairns, Nigel J
54Householder, Erin
55Taylor-Reinwald, Lisa
56Lee, Virginia
57Korecka, Magdalena
58Figurski, Michal
59Crawford, Karen
60Neu, Scott
61Foroud, Tatiana M
62Potkin, Steven
63Shen, Li
64Faber, Kelley
65Kim, Sungeun
66Nho, Kwangsik
67Thal, Lean
68Thal, Leon
69Buckholtz, Neil
70Snyder, Peter J
71Albert, Marylyn
72Frank, Richard
73Hsiao, John
74Kaye, Jeffrey
75Quinn, Joseph
76Lind, Betty
77Carter, Raina
78Dolen, Sara
79Schneider, Lon S
80Pawluczyk, Sonia
81Beccera, Mauricio
82Teodoro, Liberty
83Spann, Bryan M
84Brewer, James
85Vanderswag, Helen
86Fleisher, Adam
87Heidebrink, Judith L
88Lord, Joanne L
89Mason, Sara S
90Albers, Colleen S
91Knopman, David
92Johnson, Kris
93Doody, Rachelle S
94Villanueva-Meyer, Javier
95Chowdhury, Munir
96Rountree, Susan
97Dang, Mimi
98Stern, Yaakov
99Honig, Lawrence S
100...
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titleSubjective cognitive complaints contribute to misdiagnosis of mild cognitive impairment.
authorEdmonds, Emily C ; Delano-Wood, Lisa ; Galasko, Douglas R ; Salmon, David P ; Bondi, Mark W ; Edmonds, Emily C
creationdate20140901
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2Amyloid Beta-Peptides–Diagnosis
3Analysis of Variance–Psychology
4Attention–Cerebrospinal Fluid
5Cognitive Dysfunction–Cerebrospinal Fluid
6Diagnostic Errors–Cerebrospinal Fluid
7Discriminant Analysis–Cerebrospinal Fluid
8Female–Cerebrospinal Fluid
9Humans–Cerebrospinal Fluid
10Language–Cerebrospinal Fluid
11Male–Cerebrospinal Fluid
12Middle Aged–Cerebrospinal Fluid
13Neuropsychological Tests–Cerebrospinal Fluid
14Peptide Fragments–Cerebrospinal Fluid
15Self Report–Cerebrospinal Fluid
16Surveys and Questionnaires–Cerebrospinal Fluid
17Tau Proteins–Cerebrospinal Fluid
18Amyloid Beta-Peptides
19Peptide Fragments
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0Edmonds, Emily C
1Delano-Wood, Lisa
2Galasko, Douglas R
3Salmon, David P
4Bondi, Mark W
5Weiner, Michael W
6Aisen, Paul
7Petersen, Ronald
8Jack, Clifford R
9Jagust, William
10Trojanowki, John Q
11Toga, Arthur W
12Beckett, Laurel
13Green, Robert C
14Saykin, Andrew J
15Morris, John
16Shaw, Leslie M
17Khachaturian, Zaven
18Sorensen, Greg
19Carrillo, Maria
20Kuller, Lew
21Raichle, Marc
22Paul, Steven
23Davies, Peter
24Fillit, Howard
25Hefti, Franz
26Holtzman, Davie
27Mesulam, M Marcel
28Potter, William
29Snyder, Peter
30Schwartz, Adam
31Montine, Tom
32Thomas, Ronald G
33Donohue, Michael
34Walter, Sarah
35Gessert, Devon
36Sather, Tamie
37Jiminez, Gus
38Harvey, Danielle
39Bernstein, Matthew
40Fox, Nick
41Thompson, Paul
42Schuff, Norbert
43Decarli, Charles
44Borowski, Bret
45Gunter, Jeff
46Senjem, Matt
47Vemuri, Prashanthi
48Jones, David
49Kantarci, Kejal
50Ward, Chad
51Koeppe, Robert A
52Foster, Norm
53Reiman, Eric M
54Chen, Kewei
55Mathis, Chet
56Landau, Susan
57Morris, John C
58Cairns, Nigel J
59Householder, Erin
60Taylor-Reinwald, Lisa
61Lee, Virginia
62Korecka, Magdalena
63Figurski, Michal
64Crawford, Karen
65Neu, Scott
66Foroud, Tatiana M
67Potkin, Steven
68Shen, Li
69Faber, Kelley
70Kim, Sungeun
71Nho, Kwangsik
72Thal, Lean
73Thal, Leon
74Buckholtz, Neil
75Snyder, Peter J
76Albert, Marylyn
77Frank, Richard
78Hsiao, John
79Kaye, Jeffrey
80Quinn, Joseph
81Lind, Betty
82Carter, Raina
83Dolen, Sara
84Schneider, Lon S
85Pawluczyk, Sonia
86Beccera, Mauricio
87Teodoro, Liberty
88Spann, Bryan M
89Brewer, James
90Vanderswag, Helen
91Fleisher, Adam
92Heidebrink, Judith L
93Lord, Joanne L
94Mason, Sara S
95Albers, Colleen S
96Knopman, David
97Johnson, Kris
98Doody, Rachelle S
99Villanueva-Meyer, Javier
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7Beckett, Laurel
8Green, Robert C
9Saykin, Andrew J
10Morris, John
11Shaw, Leslie M
12Khachaturian, Zaven
13Sorensen, Greg
14Carrillo, Maria
15Kuller, Lew
16Raichle, Marc
17Paul, Steven
18Davies, Peter
19Fillit, Howard
20Hefti, Franz
21Holtzman, Davie
22Mesulam, M Marcel
23Potter, William
24Snyder, Peter
25Schwartz, Adam
26Montine, Tom
27Thomas, Ronald G
28Donohue, Michael
29Walter, Sarah
30Gessert, Devon
31Sather, Tamie
32Jiminez, Gus
33Harvey, Danielle
34Bernstein, Matthew
35Fox, Nick
36Thompson, Paul
37Schuff, Norbert
38DeCarli, Charles
39Borowski, Bret
40Gunter, Jeff
41Senjem, Matt
42Vemuri, Prashanthi
43Jones, David
44Kantarci, Kejal
45Ward, Chad
46Koeppe, Robert A
47Foster, Norm
48Reiman, Eric M
49Chen, Kewei
50Mathis, Chet
51Landau, Susan
52Morris, John C
53Cairns, Nigel J
54Householder, Erin
55Taylor-Reinwald, Lisa
56Lee, Virginia
57Korecka, Magdalena
58Figurski, Michal
59Crawford, Karen
60Neu, Scott
61Foroud, Tatiana M
62Potkin, Steven
63Shen, Li
64Faber, Kelley
65Kim, Sungeun
66Nho, Kwangsik
67Thal, Lean
68Thal, Leon
69Buckholtz, Neil
70Snyder, Peter J
71Albert, Marylyn
72Frank, Richard
73Hsiao, John
74Kaye, Jeffrey
75Quinn, Joseph
76Lind, Betty
77Carter, Raina
78Dolen, Sara
79Schneider, Lon S
80Pawluczyk, Sonia
81Beccera, Mauricio
82Teodoro, Liberty
83Spann, Bryan M
84Brewer, James
85Vanderswag, Helen
86Fleisher, Adam
87Heidebrink, Judith L
88Lord, Joanne L
89Mason, Sara S
90Albers, Colleen S
91Knopman, David
92Johnson, Kris
93Doody, Rachelle S
94Villanueva-Meyer, Javier
95Chowdhury, Munir
96Rountree, Susan
97Dang, Mimi
98Stern, Yaakov
99Honig, Lawrence S
100...
atitleSubjective cognitive complaints contribute to misdiagnosis of mild cognitive impairment.
jtitleJournal of the International Neuropsychological Society : JINS
risdate20140901
volume20
issue8
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pages836-847
eissn1469-7661
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doi10.1017/S135561771400068X
urlhttp://search.proquest.com/docview/1564354784/
issn13556177
date2014-09-01