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Translational Repression and eIF4A2 Activity Are Critical for MicroRNA-Mediated Gene Regulation

MicroRNA MechanismMicroRNAs are small noncoding RNAs that regulate gene expression by binding complementary target messenger RNAs (mRNAs) and repressing their expression through repression of protein translation and mRNA degradation. Meijer et al. (p. 82) show that in a HeLa cell system mRNA degrada... Full description

Journal Title: Science Apr 5, 2013, Vol.340(6128), pp.82-85
Main Author: Meijer, Ha
Other Authors: Kong, Y , Lu, W , Wilczynska, A , Spriggs, R , Robinson, S , Godfrey, J , Willis, A , Bushell, M
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0036-8075 ; DOI: 10.1126/science.1231197
Link: http://search.proquest.com/docview/1566853993/?pq-origsite=primo
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recordid: proquest1566853993
title: Translational Repression and eIF4A2 Activity Are Critical for MicroRNA-Mediated Gene Regulation
format: Article
creator:
  • Meijer, Ha
  • Kong, Y
  • Lu, W
  • Wilczynska, A
  • Spriggs, R
  • Robinson, S
  • Godfrey, J
  • Willis, A
  • Bushell, M
subjects:
  • Initiation Factors
  • Translation
  • Gene Regulation
  • Mirna
  • Mrna
  • Development & Cell Cycle
ispartof: Science, Apr 5, 2013, Vol.340(6128), pp.82-85
description: MicroRNA MechanismMicroRNAs are small noncoding RNAs that regulate gene expression by binding complementary target messenger RNAs (mRNAs) and repressing their expression through repression of protein translation and mRNA degradation. Meijer et al. (p. 82) show that in a HeLa cell system mRNA degradation is a consequence of translational inhibition via the initiation factor eIF4A2.
language: eng
source:
identifier: ISSN: 0036-8075 ; DOI: 10.1126/science.1231197
fulltext: no_fulltext
issn:
  • 00368075
  • 0036-8075
url: Link


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identifierISSN: 0036-8075 ; DOI: 10.1126/science.1231197
subjectInitiation Factors ; Translation ; Gene Regulation ; Mirna ; Mrna ; Development & Cell Cycle
descriptionMicroRNA MechanismMicroRNAs are small noncoding RNAs that regulate gene expression by binding complementary target messenger RNAs (mRNAs) and repressing their expression through repression of protein translation and mRNA degradation. Meijer et al. (p. 82) show that in a HeLa cell system mRNA degradation is a consequence of translational inhibition via the initiation factor eIF4A2.
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abstractMicroRNA MechanismMicroRNAs are small noncoding RNAs that regulate gene expression by binding complementary target messenger RNAs (mRNAs) and repressing their expression through repression of protein translation and mRNA degradation. Meijer et al. (p. 82) show that in a HeLa cell system mRNA degradation is a consequence of translational inhibition via the initiation factor eIF4A2.
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date2013-04-05