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Cocoon-like self-degradable DNA nanoclew for anticancer drug delivery.

A bioinspired cocoon-like anticancer drug delivery system consisting of a deoxyribonuclease (DNase)-degradable DNA nanoclew (NCl) embedded with an acid-responsive DNase I nanocapsule (NCa) was developed for targeted cancer treatment. The NCl was assembled from a long-chain single-stranded DNA synthe... Full description

Journal Title: Journal of the American Chemical Society October 22, 2014, Vol.136(42), pp.14722-14725
Main Author: Sun, Wujin
Other Authors: Jiang, Tianyue , Lu, Yue , Reiff, Margaret , Mo, Ran , Gu, Zhen
Format: Electronic Article Electronic Article
Language: English
Subjects:
DNA
ID: E-ISSN: 1520-5126 ; DOI: 1520-5126 ; DOI: 10.1021/ja5088024
Link: http://search.proquest.com/docview/1615742641/?pq-origsite=primo
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recordid: proquest1615742641
title: Cocoon-like self-degradable DNA nanoclew for anticancer drug delivery.
format: Article
creator:
  • Sun, Wujin
  • Jiang, Tianyue
  • Lu, Yue
  • Reiff, Margaret
  • Mo, Ran
  • Gu, Zhen
subjects:
  • Antineoplastic Agents–Chemistry
  • DNA–Pharmacology
  • Deoxyribonucleases–Chemistry
  • Doxorubicin–Metabolism
  • Drug Carriers–Metabolism
  • Drug Liberation–Chemistry
  • Humans–Pharmacology
  • Mcf-7 Cells–Chemistry
  • Models, Molecular–Metabolism
  • Molecular Conformation–Chemistry
  • Nanoparticles–Chemistry
  • Antineoplastic Agents
  • Drug Carriers
  • Doxorubicin
  • DNA
  • Deoxyribonucleases
ispartof: Journal of the American Chemical Society, October 22, 2014, Vol.136(42), pp.14722-14725
description: A bioinspired cocoon-like anticancer drug delivery system consisting of a deoxyribonuclease (DNase)-degradable DNA nanoclew (NCl) embedded with an acid-responsive DNase I nanocapsule (NCa) was developed for targeted cancer treatment. The NCl was assembled from a long-chain single-stranded DNA synthesized by rolling-circle amplification (RCA). Multiple GC-pair sequences were integrated into the NCl for enhanced loading capacity of the anticancer drug doxorubicin (DOX). Meanwhile, negatively charged DNase I was encapsulated in a positively charged acid-degradable polymeric nanogel to facilitate decoration of DNase I into the NCl by electrostatic interactions. In an acidic environment, the activity of DNase I was activated through the acid-triggered shedding of the polymeric shell of the NCa, resulting in the cocoon-like self-degradation of the NCl and promoting the release of DOX for enhanced therapeutic efficacy.
language: eng
source:
identifier: E-ISSN: 1520-5126 ; DOI: 1520-5126 ; DOI: 10.1021/ja5088024
fulltext: no_fulltext
issn:
  • 15205126
  • 1520-5126
url: Link


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titleCocoon-like self-degradable DNA nanoclew for anticancer drug delivery.
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subjectAntineoplastic Agents–Chemistry ; DNA–Pharmacology ; Deoxyribonucleases–Chemistry ; Doxorubicin–Metabolism ; Drug Carriers–Metabolism ; Drug Liberation–Chemistry ; Humans–Pharmacology ; Mcf-7 Cells–Chemistry ; Models, Molecular–Metabolism ; Molecular Conformation–Chemistry ; Nanoparticles–Chemistry ; Antineoplastic Agents ; Drug Carriers ; Doxorubicin ; DNA ; Deoxyribonucleases
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descriptionA bioinspired cocoon-like anticancer drug delivery system consisting of a deoxyribonuclease (DNase)-degradable DNA nanoclew (NCl) embedded with an acid-responsive DNase I nanocapsule (NCa) was developed for targeted cancer treatment. The NCl was assembled from a long-chain single-stranded DNA synthesized by rolling-circle amplification (RCA). Multiple GC-pair sequences were integrated into the NCl for enhanced loading capacity of the anticancer drug doxorubicin (DOX). Meanwhile, negatively charged DNase I was encapsulated in a positively charged acid-degradable polymeric nanogel to facilitate decoration of DNase I into the NCl by electrostatic interactions. In an acidic environment, the activity of DNase I was activated through the acid-triggered shedding of the polymeric shell of the NCa, resulting in the cocoon-like self-degradation of the NCl and promoting the release of DOX for enhanced therapeutic efficacy.
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