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Increase in Nontuberculous Mycobacteria Isolated in Shanghai, China: Results from a Population-Based Study: e109736

Background In China, the prevalence of nontuberculous mycobacteria (NTM) in isolates from mycobacterial culture-positive patients with pulmonary tuberculosis (TB) is largely unknown. Methods We used conventional biochemical and 16S rRNA gene sequencing to identify species of mycobacteria in specimen... Full description

Journal Title: PLoS ONE Oct 2014, Vol.9(10)
Main Author: Wu, Jie
Other Authors: Zhang, Yangyi , Li, Jing , Lin, Senlin , Wang, Lili , Jiang, Yuan , Pan, Qichao , Shen, Xin
Format: Electronic Article Electronic Article
Language: English
Subjects:
Age
ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0109736
Link: http://search.proquest.com/docview/1622615100/?pq-origsite=primo
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title: Increase in Nontuberculous Mycobacteria Isolated in Shanghai, China: Results from a Population-Based Study: e109736
format: Article
creator:
  • Wu, Jie
  • Zhang, Yangyi
  • Li, Jing
  • Lin, Senlin
  • Wang, Lili
  • Jiang, Yuan
  • Pan, Qichao
  • Shen, Xin
subjects:
  • Cavities
  • Population Studies
  • Streptomycin
  • Chest
  • Infection
  • Rifampin
  • Lung
  • Risk Factors
  • Ionizing Radiation
  • Geriatrics
  • Tuberculosis
  • Sputum
  • Ethambutol
  • Rrna 16s
  • Isoniazid
  • Age
  • Biochemistry
  • Risk Factors
  • Species Diversity
  • Tuberculosis
  • Infection
  • Mycobacterium Tuberculosis
  • China, People'S Rep., Shanghai
  • China, People'S Rep.
  • Medical and Environmental Health
  • Human Diseases
ispartof: PLoS ONE, Oct 2014, Vol.9(10)
description: Background In China, the prevalence of nontuberculous mycobacteria (NTM) in isolates from mycobacterial culture-positive patients with pulmonary tuberculosis (TB) is largely unknown. Methods We used conventional biochemical and 16S rRNA gene sequencing to identify species of mycobacteria in specimens from patients suspected of having TB. Drug-susceptibility testing was performed on NTM isolates using the proportion method. We also determined the independent risk factors associated with infection with NTM compared with infection with Mycobacterium tuberculosis. Results The overall rate of NTM isolated from mycobacterial culture-positive patients was 5.9% in this population, with a significantly increasing trend from 3.0% in 2008 to 8.5% in 2012 (P for trend
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0109736
fulltext: fulltext
issn:
  • 19326203
  • 1932-6203
url: Link


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titleIncrease in Nontuberculous Mycobacteria Isolated in Shanghai, China: Results from a Population-Based Study: e109736
creatorWu, Jie ; Zhang, Yangyi ; Li, Jing ; Lin, Senlin ; Wang, Lili ; Jiang, Yuan ; Pan, Qichao ; Shen, Xin
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ispartofPLoS ONE, Oct 2014, Vol.9(10)
identifierE-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0109736
subjectCavities ; Population Studies ; Streptomycin ; Chest ; Infection ; Rifampin ; Lung ; Risk Factors ; Ionizing Radiation ; Geriatrics ; Tuberculosis ; Sputum ; Ethambutol ; Rrna 16s ; Isoniazid ; Age ; Biochemistry ; Risk Factors ; Species Diversity ; Tuberculosis ; Infection ; Mycobacterium Tuberculosis ; China, People'S Rep., Shanghai ; China, People'S Rep. ; Medical and Environmental Health ; Human Diseases
descriptionBackground In China, the prevalence of nontuberculous mycobacteria (NTM) in isolates from mycobacterial culture-positive patients with pulmonary tuberculosis (TB) is largely unknown. Methods We used conventional biochemical and 16S rRNA gene sequencing to identify species of mycobacteria in specimens from patients suspected of having TB. Drug-susceptibility testing was performed on NTM isolates using the proportion method. We also determined the independent risk factors associated with infection with NTM compared with infection with Mycobacterium tuberculosis. Results The overall rate of NTM isolated from mycobacterial culture-positive patients was 5.9% in this population, with a significantly increasing trend from 3.0% in 2008 to 8.5% in 2012 (P for trend <0.001). The organism most frequently identified was M. kansasii (45.0%), followed by M. intracellulare (20.8%) and M. chelonae/abscessus (14.9%). The overall proportion of isolates resistant to the four first-line anti-TB agents were 64.6% for isoniazid, 77.6% for streptomycin, 63.3% for rifampicin and 75.1% for ethambutol. The risk factors most often associated with NTM infection were older age (P for trend <0.001), being a resident of Shanghai (adjusted odds ratio [aOR], 1.48; 95% CI, 1.10-2.00), having been treated for tuberculosis (aOR, 1.64; 95% CI, 1.18-2.29), having a cavity on chest X-ray (aOR, 1.51; 95% CI, 1.16-1.96), and being sputum smear-negative (aOR, 1.59; 95% CI, 1.16-2.18). Conclusions The prevalence of NTM isolated in Shanghai increased between 2008 and 2012, thus clinicians should consider NTM as a possible cause of TB-like disease. Accurate species identification is imperative so that proper treatment can be administered for diseases caused by the diversity of NTM species.
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titleIncrease in Nontuberculous Mycobacteria Isolated in Shanghai, China: Results from a Population-Based Study: e109736
descriptionBackground In China, the prevalence of nontuberculous mycobacteria (NTM) in isolates from mycobacterial culture-positive patients with pulmonary tuberculosis (TB) is largely unknown. Methods We used conventional biochemical and 16S rRNA gene sequencing to identify species of mycobacteria in specimens from patients suspected of having TB. Drug-susceptibility testing was performed on NTM isolates using the proportion method. We also determined the independent risk factors associated with infection with NTM compared with infection with Mycobacterium tuberculosis. Results The overall rate of NTM isolated from mycobacterial culture-positive patients was 5.9% in this population, with a significantly increasing trend from 3.0% in 2008 to 8.5% in 2012 (P for trend <0.001). The organism most frequently identified was M. kansasii (45.0%), followed by M. intracellulare (20.8%) and M. chelonae/abscessus (14.9%). The overall proportion of isolates resistant to the four first-line anti-TB agents were 64.6% for isoniazid, 77.6% for streptomycin, 63.3% for rifampicin and 75.1% for ethambutol. The risk factors most often associated with NTM infection were older age (P for trend <0.001), being a resident of Shanghai (adjusted odds ratio [aOR], 1.48; 95% CI, 1.10-2.00), having been treated for tuberculosis (aOR, 1.64; 95% CI, 1.18-2.29), having a cavity on chest X-ray (aOR, 1.51; 95% CI, 1.16-1.96), and being sputum smear-negative (aOR, 1.59; 95% CI, 1.16-2.18). Conclusions The prevalence of NTM isolated in Shanghai increased between 2008 and 2012, thus clinicians should consider NTM as a possible cause of TB-like disease. Accurate species identification is imperative so that proper treatment can be administered for diseases caused by the diversity of NTM species.
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titleIncrease in Nontuberculous Mycobacteria Isolated in Shanghai, China: Results from a Population-Based Study: e109736
authorWu, Jie ; Zhang, Yangyi ; Li, Jing ; Lin, Senlin ; Wang, Lili ; Jiang, Yuan ; Pan, Qichao ; Shen, Xin
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abstractBackground In China, the prevalence of nontuberculous mycobacteria (NTM) in isolates from mycobacterial culture-positive patients with pulmonary tuberculosis (TB) is largely unknown. Methods We used conventional biochemical and 16S rRNA gene sequencing to identify species of mycobacteria in specimens from patients suspected of having TB. Drug-susceptibility testing was performed on NTM isolates using the proportion method. We also determined the independent risk factors associated with infection with NTM compared with infection with Mycobacterium tuberculosis. Results The overall rate of NTM isolated from mycobacterial culture-positive patients was 5.9% in this population, with a significantly increasing trend from 3.0% in 2008 to 8.5% in 2012 (P for trend <0.001). The organism most frequently identified was M. kansasii (45.0%), followed by M. intracellulare (20.8%) and M. chelonae/abscessus (14.9%). The overall proportion of isolates resistant to the four first-line anti-TB agents were 64.6% for isoniazid, 77.6% for streptomycin, 63.3% for rifampicin and 75.1% for ethambutol. The risk factors most often associated with NTM infection were older age (P for trend <0.001), being a resident of Shanghai (adjusted odds ratio [aOR], 1.48; 95% CI, 1.10-2.00), having been treated for tuberculosis (aOR, 1.64; 95% CI, 1.18-2.29), having a cavity on chest X-ray (aOR, 1.51; 95% CI, 1.16-1.96), and being sputum smear-negative (aOR, 1.59; 95% CI, 1.16-2.18). Conclusions The prevalence of NTM isolated in Shanghai increased between 2008 and 2012, thus clinicians should consider NTM as a possible cause of TB-like disease. Accurate species identification is imperative so that proper treatment can be administered for diseases caused by the diversity of NTM species.
doi10.1371/journal.pone.0109736
urlhttp://search.proquest.com/docview/1622615100/
pagese109736
date2014-10-01