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Large-scale topology and the default mode network in the mouse connectome.

Noninvasive functional imaging holds great promise for serving as a translational bridge between human and animal models of various neurological and psychiatric disorders. However, despite a depth of knowledge of the cellular and molecular underpinnings of atypical processes in mouse models, little... Full description

Journal Title: Proceedings of the National Academy of Sciences of the United States of America December 30, 2014, Vol.111(52), pp.18745-18750
Main Author: Stafford, James M
Other Authors: Jarrett, Benjamin R , Miranda-Dominguez, Oscar , Mills, Brian D , Cain, Nicholas , Mihalas, Stefan , Lahvis, Garet P , Lattal, K Matthew , Mitchell, Suzanne H , David, Stephen V , Fryer, John D , Nigg, Joel T , Fair, Damien A
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1091-6490 ; DOI: 10.1073/pnas.1404346111
Link: http://search.proquest.com/docview/1641426646/?pq-origsite=primo
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title: Large-scale topology and the default mode network in the mouse connectome.
format: Article
creator:
  • Stafford, James M
  • Jarrett, Benjamin R
  • Miranda-Dominguez, Oscar
  • Mills, Brian D
  • Cain, Nicholas
  • Mihalas, Stefan
  • Lahvis, Garet P
  • Lattal, K Matthew
  • Mitchell, Suzanne H
  • David, Stephen V
  • Fryer, John D
  • Nigg, Joel T
  • Fair, Damien A
subjects:
  • Animals–Pathology
  • Axons–Pathology
  • Connectome–Physiopathology
  • Disease Models, Animal–Pathology
  • Humans–Physiopathology
  • Magnetic Resonance Imaging–Pathology
  • Male–Physiopathology
  • Mice–Physiopathology
  • Nerve Net–Physiopathology
  • Nervous System Diseases–Physiopathology
  • Psychotic Disorders–Physiopathology
  • Connectivity
  • Default Mode Network
  • Mouse
  • Resting-State Functional Mri
  • Structural Connectivity
ispartof: Proceedings of the National Academy of Sciences of the United States of America, December 30, 2014, Vol.111(52), pp.18745-18750
description: Noninvasive functional imaging holds great promise for serving as a translational bridge between human and animal models of various neurological and psychiatric disorders. However, despite a depth of knowledge of the cellular and molecular underpinnings of atypical processes in mouse models, little is known about the large-scale functional architecture measured by functional brain imaging, limiting translation to human conditions. Here, we provide a robust processing pipeline to generate high-resolution, whole-brain resting-state functional connectivity MRI (rs-fcMRI) images in the mouse. Using a mesoscale structural connectome (i.e., an anterograde tracer mapping of axonal projections across the mouse CNS), we show that rs-fcMRI in the mouse has strong structural underpinnings, validating our procedures. We next directly show that large-scale network properties previously identified in primates are present in rodents, although they differ in several ways. Last, we examine the existence of the so-called default mode network (DMN)--a distributed functional brain system identified in primates as being highly important for social cognition and overall brain function and atypically functionally connected across a multitude of disorders. We show the presence of a potential DMN in the mouse brain both structurally and functionally. Together, these studies confirm the presence of basic network properties and functional networks of high translational importance in structural and functional systems in the mouse brain. This work clears the way for an important bridge measurement between human and rodent models, enabling us to make stronger conclusions about how regionally specific cellular and molecular manipulations in mice relate back to humans.
language: eng
source:
identifier: E-ISSN: 1091-6490 ; DOI: 10.1073/pnas.1404346111
fulltext: fulltext
issn:
  • 10916490
  • 1091-6490
url: Link


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titleLarge-scale topology and the default mode network in the mouse connectome.
creatorStafford, James M ; Jarrett, Benjamin R ; Miranda-Dominguez, Oscar ; Mills, Brian D ; Cain, Nicholas ; Mihalas, Stefan ; Lahvis, Garet P ; Lattal, K Matthew ; Mitchell, Suzanne H ; David, Stephen V ; Fryer, John D ; Nigg, Joel T ; Fair, Damien A
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subjectAnimals–Pathology ; Axons–Pathology ; Connectome–Physiopathology ; Disease Models, Animal–Pathology ; Humans–Physiopathology ; Magnetic Resonance Imaging–Pathology ; Male–Physiopathology ; Mice–Physiopathology ; Nerve Net–Physiopathology ; Nervous System Diseases–Physiopathology ; Psychotic Disorders–Physiopathology ; Connectivity ; Default Mode Network ; Mouse ; Resting-State Functional Mri ; Structural Connectivity
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descriptionNoninvasive functional imaging holds great promise for serving as a translational bridge between human and animal models of various neurological and psychiatric disorders. However, despite a depth of knowledge of the cellular and molecular underpinnings of atypical processes in mouse models, little is known about the large-scale functional architecture measured by functional brain imaging, limiting translation to human conditions. Here, we provide a robust processing pipeline to generate high-resolution, whole-brain resting-state functional connectivity MRI (rs-fcMRI) images in the mouse. Using a mesoscale structural connectome (i.e., an anterograde tracer mapping of axonal projections across the mouse CNS), we show that rs-fcMRI in the mouse has strong structural underpinnings, validating our procedures. We next directly show that large-scale network properties previously identified in primates are present in rodents, although they differ in several ways. Last, we examine the existence of the so-called default mode network (DMN)--a distributed functional brain system identified in primates as being highly important for social cognition and overall brain function and atypically functionally connected across a multitude of disorders. We show the presence of a potential DMN in the mouse brain both structurally and functionally. Together, these studies confirm the presence of basic network properties and functional networks of high translational importance in structural and functional systems in the mouse brain. This work clears the way for an important bridge measurement between human and rodent models, enabling us to make stronger conclusions about how regionally specific cellular and molecular manipulations in mice relate back to humans.
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