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Evaluation of antinociceptive activity of nanoliposome-encapsulated and free-form diclofenac in rats and mice.

Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, antinociceptive, and antipyretic activities. Liposomes have been shown to improve the therapeutic efficacy of encapsulated drugs. The present study was conducted to compare the antinociceptive properties bet... Full description

Journal Title: International journal of nanomedicine 2015, Vol.10, pp.297-303
Main Author: Goh, Jun Zheng
Other Authors: Tang, Sook Nai , Chiong, Hoe Siong , Yong, Yoke Keong , Zuraini, Ahmad , Hakim, Muhammad Nazrul
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1178-2013 ; DOI: 10.2147/IJN.S75545
Link: http://search.proquest.com/docview/1656045640/?pq-origsite=primo
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title: Evaluation of antinociceptive activity of nanoliposome-encapsulated and free-form diclofenac in rats and mice.
format: Article
creator:
  • Goh, Jun Zheng
  • Tang, Sook Nai
  • Chiong, Hoe Siong
  • Yong, Yoke Keong
  • Zuraini, Ahmad
  • Hakim, Muhammad Nazrul
subjects:
  • Acetic Acid–Toxicity
  • Analgesics–Administration & Dosage
  • Animals–Pharmacology
  • Anti-Inflammatory Agents, Non-Steroidal–Administration & Dosage
  • Carrageenan–Pharmacology
  • Diclofenac–Toxicity
  • Edema–Administration & Dosage
  • Liposomes–Pharmacology
  • Male–Chemically Induced
  • Mice–Drug Therapy
  • Mice, Inbred Balb C–Administration & Dosage
  • Nanoparticles–Administration & Dosage
  • Pain–Chemically Induced
  • Pain Measurement–Drug Therapy
  • Rats–Drug Effects
  • Rats, Sprague-Dawley–Drug Effects
  • Analgesics
  • Anti-Inflammatory Agents, Non-Steroidal
  • Liposomes
  • Diclofenac
  • Carrageenan
  • Acetic Acid
  • Antinociceptive
  • Diclofenac
  • Efficacy
  • Liposome
  • Nanoencapsulation
ispartof: International journal of nanomedicine, 2015, Vol.10, pp.297-303
description: Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, antinociceptive, and antipyretic activities. Liposomes have been shown to improve the therapeutic efficacy of encapsulated drugs. The present study was conducted to compare the antinociceptive properties between liposome-encapsulated and free-form diclofenac in vivo via different nociceptive assay models. Liposome-encapsulated diclofenac was prepared using the commercialized proliposome method. Antinociceptive effects of liposome-encapsulated and free-form diclofenac were evaluated using formalin test, acetic acid-induced abdominal writhing test, Randall-Selitto paw pressure test, and plantar test. The results of the writhing test showed a significant reduction of abdominal constriction in all treatment groups in a dose-dependent manner. The 20 mg/kg liposome-encapsulated diclofenac demonstrated the highest antinociceptive effect at 78.97% compared with 55.89% in the free-form group at equivalent dosage. Both liposome-encapsulated and free-form diclofenac produced significant results in the late phase of formalin assay at a dose of 20 mg/kg, with antinociception percentages of 78.84% and 60.71%, respectively. Significant results of antinociception were also observed in both hyperalgesia assays. For Randall-Sellito assay, the highest antinociception effect of 71.38% was achieved with 20 mg/kg liposome-encapsulated diclofenac, while the lowest antinociceptive effect of 17.32% was recorded with 0 mg/kg liposome formulation, whereas in the plantar test, the highest antinociceptive effect was achieved at 56.7% with 20 mg/kg liposome-encapsulated diclofenac, and the lowest effect was shown with 0 mg/kg liposome formulation of 8.89%. The present study suggests that liposome-encapsulated diclofenac exhibits higher antinociceptive efficacy in a dose-dependent manner in comparison with free-form diclofenac. Keywords: diclofenac, liposome, nanoencapsulation, efficacy, antinociceptive
language: eng
source:
identifier: E-ISSN: 1178-2013 ; DOI: 10.2147/IJN.S75545
fulltext: fulltext
issn:
  • 11782013
  • 1178-2013
url: Link


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titleEvaluation of antinociceptive activity of nanoliposome-encapsulated and free-form diclofenac in rats and mice.
creatorGoh, Jun Zheng ; Tang, Sook Nai ; Chiong, Hoe Siong ; Yong, Yoke Keong ; Zuraini, Ahmad ; Hakim, Muhammad Nazrul
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ispartofInternational journal of nanomedicine, 2015, Vol.10, pp.297-303
identifierE-ISSN: 1178-2013 ; DOI: 10.2147/IJN.S75545
subjectAcetic Acid–Toxicity ; Analgesics–Administration & Dosage ; Animals–Pharmacology ; Anti-Inflammatory Agents, Non-Steroidal–Administration & Dosage ; Carrageenan–Pharmacology ; Diclofenac–Toxicity ; Edema–Administration & Dosage ; Liposomes–Pharmacology ; Male–Chemically Induced ; Mice–Drug Therapy ; Mice, Inbred Balb C–Administration & Dosage ; Nanoparticles–Administration & Dosage ; Pain–Chemically Induced ; Pain Measurement–Drug Therapy ; Rats–Drug Effects ; Rats, Sprague-Dawley–Drug Effects ; Analgesics ; Anti-Inflammatory Agents, Non-Steroidal ; Liposomes ; Diclofenac ; Carrageenan ; Acetic Acid ; Antinociceptive ; Diclofenac ; Efficacy ; Liposome ; Nanoencapsulation
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descriptionDiclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that exhibits anti-inflammatory, antinociceptive, and antipyretic activities. Liposomes have been shown to improve the therapeutic efficacy of encapsulated drugs. The present study was conducted to compare the antinociceptive properties between liposome-encapsulated and free-form diclofenac in vivo via different nociceptive assay models. Liposome-encapsulated diclofenac was prepared using the commercialized proliposome method. Antinociceptive effects of liposome-encapsulated and free-form diclofenac were evaluated using formalin test, acetic acid-induced abdominal writhing test, Randall-Selitto paw pressure test, and plantar test. The results of the writhing test showed a significant reduction of abdominal constriction in all treatment groups in a dose-dependent manner. The 20 mg/kg liposome-encapsulated diclofenac demonstrated the highest antinociceptive effect at 78.97% compared with 55.89% in the free-form group at equivalent dosage. Both liposome-encapsulated and free-form diclofenac produced significant results in the late phase of formalin assay at a dose of 20 mg/kg, with antinociception percentages of 78.84% and 60.71%, respectively. Significant results of antinociception were also observed in both hyperalgesia assays. For Randall-Sellito assay, the highest antinociception effect of 71.38% was achieved with 20 mg/kg liposome-encapsulated diclofenac, while the lowest antinociceptive effect of 17.32% was recorded with 0 mg/kg liposome formulation, whereas in the plantar test, the highest antinociceptive effect was achieved at 56.7% with 20 mg/kg liposome-encapsulated diclofenac, and the lowest effect was shown with 0 mg/kg liposome formulation of 8.89%. The present study suggests that liposome-encapsulated diclofenac exhibits higher antinociceptive efficacy in a dose-dependent manner in comparison with free-form diclofenac. Keywords: diclofenac, liposome, nanoencapsulation, efficacy, antinociceptive
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