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MicroRNA-410 regulated lipoprotein lipase variant rs13702 is associated with stroke incidence and modulated by diet in the randomized controlled PREDIMED trial.

BACKGROUNDMicroRNAs have emerged as important epigenetic regulators in cardiovascular diseases (CVDs). Using an observational meta-analysis design, we previously characterized a gain-of-function microRNA-410 target site polymorphism (rs13702T>C) in the 3'untranslated region of the lipoprotein lipase... Full description

Journal Title: The American journal of clinical nutrition August 2014, Vol.100(2), pp.719-731
Main Author: Corella, Dolores
Other Authors: Sorlí, Jose V , Estruch, Ramon , Coltell, Oscar , Ortega-Azorín, Carolina , Portolés, Olga , Martínez-González, Miguel Ángel , Bulló, Mónica , Fitó, Montserrat , Arós, Fernando , Lapetra, José , Asensio, Eva M , Sáez, Guillermo T , Serra-Majem, Lluís , Muñoz-Bravo, Carlos , Ruiz-Gutiérrez, Valentina , Fiol, Miquel , Vinyoles, Ernest , Pintó, Xavier , Richardson, Kris , Ros, Emilio , Ordovás, Jose M
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1938-3207 ; DOI: 1938-3207 ; DOI: 10.3945/ajcn.113.076992
Link: http://search.proquest.com/docview/1659768303/?pq-origsite=primo
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title: MicroRNA-410 regulated lipoprotein lipase variant rs13702 is associated with stroke incidence and modulated by diet in the randomized controlled PREDIMED trial.
format: Article
creator:
  • Corella, Dolores
  • Sorlí, Jose V
  • Estruch, Ramon
  • Coltell, Oscar
  • Ortega-Azorín, Carolina
  • Portolés, Olga
  • Martínez-González, Miguel Ángel
  • Bulló, Mónica
  • Fitó, Montserrat
  • Arós, Fernando
  • Lapetra, José
  • Asensio, Eva M
  • Sáez, Guillermo T
  • Serra-Majem, Lluís
  • Muñoz-Bravo, Carlos
  • Ruiz-Gutiérrez, Valentina
  • Fiol, Miquel
  • Vinyoles, Ernest
  • Pintó, Xavier
  • Richardson, Kris
  • Ros, Emilio
  • Ordovás, Jose M
subjects:
  • 3' Untranslated Regions–Diet Therapy
  • Aged–Genetics
  • Aged, 80 and Over–Metabolism
  • Cohort Studies–Physiopathology
  • Diet, Mediterranean–Chemistry
  • Female–Genetics
  • Follow-Up Studies–Metabolism
  • Genetic Association Studies–Metabolism
  • Humans–Therapeutic Use
  • Hypertriglyceridemia–Epidemiology
  • Incidence–Epidemiology
  • Lipoprotein Lipase–Etiology
  • Male–Prevention & Control
  • Micrornas–Prevention & Control
  • Middle Aged–Prevention & Control
  • Nuts–Prevention & Control
  • Olive Oil–Prevention & Control
  • Plant Oils–Prevention & Control
  • Polymorphism, Single Nucleotide–Prevention & Control
  • Risk Factors–Prevention & Control
  • Spain–Prevention & Control
  • Stroke–Prevention & Control
  • Survival Analysis–Prevention & Control
  • Abridged
  • 3' Untranslated Regions
  • Mirn410 Microrna, Human
  • Micrornas
  • Olive Oil
  • Plant Oils
  • Lpl Protein, Human
  • Lipoprotein Lipase
ispartof: The American journal of clinical nutrition, August 2014, Vol.100(2), pp.719-731
description: BACKGROUNDMicroRNAs have emerged as important epigenetic regulators in cardiovascular diseases (CVDs). Using an observational meta-analysis design, we previously characterized a gain-of-function microRNA-410 target site polymorphism (rs13702T>C) in the 3'untranslated region of the lipoprotein lipase (LPL) gene. The C allele was associated with lower triglycerides, and this association was modulated by fat intake. OBJECTIVESWe aimed to extend our findings by assessing the interaction between the rs13702 polymorphism and fat intake on triglycerides at baseline and longitudinally by using a dietary intervention design. We also examined as a primary outcome the association of this variant with CVD incidence and its modulation by the Mediterranean diet (MedDiet). DESIGNWe studied 7187 participants in the PREDIMED (Prevención con Dieta Mediterránea) randomized trial that tested a MedDiet intervention compared with a control diet, with a median 4.8-y follow-up. LPL polymorphisms and triglycerides were determined and CVD assessed. Gene-diet interactions for triglycerides were analyzed at baseline (n = 6880) and after a 3-y intervention (n = 4131). Oxidative stress parameters were investigated in a subsample. RESULTSThe rs13702T>C polymorphism was strongly associated with lower triglycerides in C allele carriers and interacted synergistically with dietary monounsaturated (P = 0.038) and unsaturated fat intake (P = 0.037), decreasing triglycerides at baseline. By 3 y, we observed a gene-diet interaction (P = 0.025) in which the C allele was associated with a greater reduction in triglycerides after intervention with MedDiet, high in unsaturated fat. Although the polymorphism was associated with lower stroke risk (HR: 0.74; 95% CI: 0.57, 0.97; P = 0.029 per C allele), this association reached statistical significance only in the MedDiet intervention (HR: 0.58; 95% CI: 0.37, 0.91; P = 0.019 in C compared with TT carriers), not in the control group (HR: 0.94; 95% CI: 0.55, 1.59; P = 0.805). CONCLUSIONWe report a novel association between a microRNA target site variant and stroke incidence, which is modulated by diet in terms of decreasing triglycerides and possibly stroke risk in rs13702 C allele carriers after a high-unsaturated fat MedDiet intervention.
language: eng
source:
identifier: E-ISSN: 1938-3207 ; DOI: 1938-3207 ; DOI: 10.3945/ajcn.113.076992
fulltext: fulltext
issn:
  • 19383207
  • 1938-3207
url: Link


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titleMicroRNA-410 regulated lipoprotein lipase variant rs13702 is associated with stroke incidence and modulated by diet in the randomized controlled PREDIMED trial.
creatorCorella, Dolores ; Sorlí, Jose V ; Estruch, Ramon ; Coltell, Oscar ; Ortega-Azorín, Carolina ; Portolés, Olga ; Martínez-González, Miguel Ángel ; Bulló, Mónica ; Fitó, Montserrat ; Arós, Fernando ; Lapetra, José ; Asensio, Eva M ; Sáez, Guillermo T ; Serra-Majem, Lluís ; Muñoz-Bravo, Carlos ; Ruiz-Gutiérrez, Valentina ; Fiol, Miquel ; Vinyoles, Ernest ; Pintó, Xavier ; Richardson, Kris ; Ros, Emilio ; Ordovás, Jose M
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descriptionBACKGROUNDMicroRNAs have emerged as important epigenetic regulators in cardiovascular diseases (CVDs). Using an observational meta-analysis design, we previously characterized a gain-of-function microRNA-410 target site polymorphism (rs13702T>C) in the 3'untranslated region of the lipoprotein lipase (LPL) gene. The C allele was associated with lower triglycerides, and this association was modulated by fat intake. OBJECTIVESWe aimed to extend our findings by assessing the interaction between the rs13702 polymorphism and fat intake on triglycerides at baseline and longitudinally by using a dietary intervention design. We also examined as a primary outcome the association of this variant with CVD incidence and its modulation by the Mediterranean diet (MedDiet). DESIGNWe studied 7187 participants in the PREDIMED (Prevención con Dieta Mediterránea) randomized trial that tested a MedDiet intervention compared with a control diet, with a median 4.8-y follow-up. LPL polymorphisms and triglycerides were determined and CVD assessed. Gene-diet interactions for triglycerides were analyzed at baseline (n = 6880) and after a 3-y intervention (n = 4131). Oxidative stress parameters were investigated in a subsample. RESULTSThe rs13702T>C polymorphism was strongly associated with lower triglycerides in C allele carriers and interacted synergistically with dietary monounsaturated (P = 0.038) and unsaturated fat intake (P = 0.037), decreasing triglycerides at baseline. By 3 y, we observed a gene-diet interaction (P = 0.025) in which the C allele was associated with a greater reduction in triglycerides after intervention with MedDiet, high in unsaturated fat. Although the polymorphism was associated with lower stroke risk (HR: 0.74; 95% CI: 0.57, 0.97; P = 0.029 per C allele), this association reached statistical significance only in the MedDiet intervention (HR: 0.58; 95% CI: 0.37, 0.91; P = 0.019 in C compared with TT carriers), not in the control group (HR: 0.94; 95% CI: 0.55, 1.59; P = 0.805). CONCLUSIONWe report a novel association between a microRNA target site variant and stroke incidence, which is modulated by diet in terms of decreasing triglycerides and possibly stroke risk in rs13702 C allele carriers after a high-unsaturated fat MedDiet intervention.
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14Muñoz-Bravo, Carlos
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20Ros, Emilio
21Ordovás, Jose M
titleMicroRNA-410 regulated lipoprotein lipase variant rs13702 is associated with stroke incidence and modulated by diet in the randomized controlled PREDIMED trial.
descriptionBACKGROUNDMicroRNAs have emerged as important epigenetic regulators in cardiovascular diseases (CVDs). Using an observational meta-analysis design, we previously characterized a gain-of-function microRNA-410 target site polymorphism (rs13702T>C) in the 3'untranslated region of the lipoprotein lipase (LPL) gene. The C allele was associated with lower triglycerides, and this association was modulated by fat intake. OBJECTIVESWe aimed to extend our findings by assessing the interaction between the rs13702 polymorphism and fat intake on triglycerides at baseline and longitudinally by using a dietary intervention design. We also examined as a primary outcome the association of this variant with CVD incidence and its modulation by the Mediterranean diet (MedDiet). DESIGNWe studied 7187 participants in the PREDIMED (Prevención con Dieta Mediterránea) randomized trial that tested a MedDiet intervention compared with a control diet, with a median 4.8-y follow-up. LPL polymorphisms and triglycerides were determined and CVD assessed. Gene-diet interactions for triglycerides were analyzed at baseline (n = 6880) and after a 3-y intervention (n = 4131). Oxidative stress parameters were investigated in a subsample. RESULTSThe rs13702T>C polymorphism was strongly associated with lower triglycerides in C allele carriers and interacted synergistically with dietary monounsaturated (P = 0.038) and unsaturated fat intake (P = 0.037), decreasing triglycerides at baseline. By 3 y, we observed a gene-diet interaction (P = 0.025) in which the C allele was associated with a greater reduction in triglycerides after intervention with MedDiet, high in unsaturated fat. Although the polymorphism was associated with lower stroke risk (HR: 0.74; 95% CI: 0.57, 0.97; P = 0.029 per C allele), this association reached statistical significance only in the MedDiet intervention (HR: 0.58; 95% CI: 0.37, 0.91; P = 0.019 in C compared with TT carriers), not in the control group (HR: 0.94; 95% CI: 0.55, 1.59; P = 0.805). CONCLUSIONWe report a novel association between a microRNA target site variant and stroke incidence, which is modulated by diet in terms of decreasing triglycerides and possibly stroke risk in rs13702 C allele carriers after a high-unsaturated fat MedDiet intervention.
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03' Untranslated Regions–Diet Therapy
1Aged–Genetics
2Aged, 80 and Over–Metabolism
3Cohort Studies–Physiopathology
4Diet, Mediterranean–Chemistry
5Female–Genetics
6Follow-Up Studies–Metabolism
7Genetic Association Studies–Metabolism
8Humans–Therapeutic Use
9Hypertriglyceridemia–Epidemiology
10Incidence–Epidemiology
11Lipoprotein Lipase–Etiology
12Male–Prevention & Control
13Micrornas–Prevention & Control
14Middle Aged–Prevention & Control
15Nuts–Prevention & Control
16Olive Oil–Prevention & Control
17Plant Oils–Prevention & Control
18Polymorphism, Single Nucleotide–Prevention & Control
19Risk Factors–Prevention & Control
20Spain–Prevention & Control
21Stroke–Prevention & Control
22Survival Analysis–Prevention & Control
23Abridged
243' Untranslated Regions
25Mirn410 Microrna, Human
26Micrornas
27Olive Oil
28Plant Oils
29Lpl Protein, Human
30Lipoprotein Lipase
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titleMicroRNA-410 regulated lipoprotein lipase variant rs13702 is associated with stroke incidence and modulated by diet in the randomized controlled PREDIMED trial.
authorCorella, Dolores ; Sorlí, Jose V ; Estruch, Ramon ; Coltell, Oscar ; Ortega-Azorín, Carolina ; Portolés, Olga ; Martínez-González, Miguel Ángel ; Bulló, Mónica ; Fitó, Montserrat ; Arós, Fernando ; Lapetra, José ; Asensio, Eva M ; Sáez, Guillermo T ; Serra-Majem, Lluís ; Muñoz-Bravo, Carlos ; Ruiz-Gutiérrez, Valentina ; Fiol, Miquel ; Vinyoles, Ernest ; Pintó, Xavier ; Richardson, Kris ; Ros, Emilio ; Ordovás, Jose M
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03' Untranslated Regions–Diet Therapy
1Aged–Genetics
2Aged, 80 and Over–Metabolism
3Cohort Studies–Physiopathology
4Diet, Mediterranean–Chemistry
5Female–Genetics
6Follow-Up Studies–Metabolism
7Genetic Association Studies–Metabolism
8Humans–Therapeutic Use
9Hypertriglyceridemia–Epidemiology
10Incidence–Epidemiology
11Lipoprotein Lipase–Etiology
12Male–Prevention & Control
13Micrornas–Prevention & Control
14Middle Aged–Prevention & Control
15Nuts–Prevention & Control
16Olive Oil–Prevention & Control
17Plant Oils–Prevention & Control
18Polymorphism, Single Nucleotide–Prevention & Control
19Risk Factors–Prevention & Control
20Spain–Prevention & Control
21Stroke–Prevention & Control
22Survival Analysis–Prevention & Control
23Abridged
243' Untranslated Regions
25Mirn410 Microrna, Human
26Micrornas
27Olive Oil
28Plant Oils
29Lpl Protein, Human
30Lipoprotein Lipase
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11Asensio, Eva M
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13Serra-Majem, Lluís
14Muñoz-Bravo, Carlos
15Ruiz-Gutiérrez, Valentina
16Fiol, Miquel
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abstractBACKGROUNDMicroRNAs have emerged as important epigenetic regulators in cardiovascular diseases (CVDs). Using an observational meta-analysis design, we previously characterized a gain-of-function microRNA-410 target site polymorphism (rs13702T>C) in the 3'untranslated region of the lipoprotein lipase (LPL) gene. The C allele was associated with lower triglycerides, and this association was modulated by fat intake. OBJECTIVESWe aimed to extend our findings by assessing the interaction between the rs13702 polymorphism and fat intake on triglycerides at baseline and longitudinally by using a dietary intervention design. We also examined as a primary outcome the association of this variant with CVD incidence and its modulation by the Mediterranean diet (MedDiet). DESIGNWe studied 7187 participants in the PREDIMED (Prevención con Dieta Mediterránea) randomized trial that tested a MedDiet intervention compared with a control diet, with a median 4.8-y follow-up. LPL polymorphisms and triglycerides were determined and CVD assessed. Gene-diet interactions for triglycerides were analyzed at baseline (n = 6880) and after a 3-y intervention (n = 4131). Oxidative stress parameters were investigated in a subsample. RESULTSThe rs13702T>C polymorphism was strongly associated with lower triglycerides in C allele carriers and interacted synergistically with dietary monounsaturated (P = 0.038) and unsaturated fat intake (P = 0.037), decreasing triglycerides at baseline. By 3 y, we observed a gene-diet interaction (P = 0.025) in which the C allele was associated with a greater reduction in triglycerides after intervention with MedDiet, high in unsaturated fat. Although the polymorphism was associated with lower stroke risk (HR: 0.74; 95% CI: 0.57, 0.97; P = 0.029 per C allele), this association reached statistical significance only in the MedDiet intervention (HR: 0.58; 95% CI: 0.37, 0.91; P = 0.019 in C compared with TT carriers), not in the control group (HR: 0.94; 95% CI: 0.55, 1.59; P = 0.805). CONCLUSIONWe report a novel association between a microRNA target site variant and stroke incidence, which is modulated by diet in terms of decreasing triglycerides and possibly stroke risk in rs13702 C allele carriers after a high-unsaturated fat MedDiet intervention.
doi10.3945/ajcn.113.076992
urlhttp://search.proquest.com/docview/1659768303/
issn00029165
date2014-08-01