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RMP predicts survival and adjuvant TACE response in hepatocellular carcinoma.

Adjuvant transcatheter arterial chemoembolization (TACE) protects against hepatocellular carcinoma (HCC) and is associated with reduced disease recurrence and improved outcome after surgery. However, deterioration of liver function after TACE negatively impacts the patient prognosis and limits it us... Full description

Journal Title: Oncotarget February 20, 2015, Vol.6(5), pp.3432-3442
Main Author: Zhang, Jian
Other Authors: Jiang, Tian-Yi , Jiang, Bei-Ge , Yang, Chun , Tan, Ye-Xiong , Yang, Ning , Pan, Yu-Fei , Ding, Zhi-Wen , Yang, Guang-Zhen , Wu, Meng-Chao , Dong, Li-Wei , Wang, Hong-Yang
Format: Electronic Article Electronic Article
Language: English
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ID: E-ISSN: 1949-2553
Link: http://search.proquest.com/docview/1661327669/?pq-origsite=primo
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recordid: proquest1661327669
title: RMP predicts survival and adjuvant TACE response in hepatocellular carcinoma.
format: Article
creator:
  • Zhang, Jian
  • Jiang, Tian-Yi
  • Jiang, Bei-Ge
  • Yang, Chun
  • Tan, Ye-Xiong
  • Yang, Ning
  • Pan, Yu-Fei
  • Ding, Zhi-Wen
  • Yang, Guang-Zhen
  • Wu, Meng-Chao
  • Dong, Li-Wei
  • Wang, Hong-Yang
subjects:
  • Adult–Analysis
  • Aged–Chemistry
  • Biomarkers, Tumor–Mortality
  • Carcinoma, Hepatocellular–Pathology
  • Chemoembolization, Therapeutic–Therapy
  • Chemotherapy, Adjuvant–Analysis
  • Disease-Free Survival–Chemistry
  • Female–Mortality
  • Hepatectomy–Pathology
  • Humans–Therapy
  • Immunohistochemistry–Therapy
  • Intracellular Signaling Peptides and Proteins–Therapy
  • Kaplan-Meier Estimate–Therapy
  • Liver Neoplasms–Therapy
  • Male–Therapy
  • Middle Aged–Therapy
  • Multivariate Analysis–Therapy
  • Neoplasm Recurrence, Local–Therapy
  • Patient Selection–Therapy
  • Predictive Value of Tests–Therapy
  • Proportional Hazards Models–Therapy
  • Risk Factors–Therapy
  • Time Factors–Therapy
  • Treatment Outcome–Therapy
  • Young Adult–Therapy
  • Biomarkers, Tumor
  • Intracellular Signaling Peptides and Proteins
  • Uri1 Protein, Human
ispartof: Oncotarget, February 20, 2015, Vol.6(5), pp.3432-3442
description: Adjuvant transcatheter arterial chemoembolization (TACE) protects against hepatocellular carcinoma (HCC) and is associated with reduced disease recurrence and improved outcome after surgery. However, deterioration of liver function after TACE negatively impacts the patient prognosis and limits it use as an option to prolong survival. We analyzed two independent cohorts that included a total of 510 patients with HCC who had undergone tumor resection. Immunohistochemistry assay was used to measure RPB5-mediating protein (RMP) expression and assessed their association with recurrence rate and response to therapy with adjuvant TACE. In patients with HCC, the expression of RMP in tumor is associated with age, gender, tumor size, portal venous invasion, TNM stages, BCLC stages and overall survival. Among patients with high RMP expression, adjuvant TACE after resection was associated with early recurrence. Even in the patients with small tumor size (no more than 5 cm) or no venous invasion, RMP...
language: eng
source:
identifier: E-ISSN: 1949-2553
fulltext: fulltext
issn:
  • 19492553
  • 1949-2553
url: Link


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titleRMP predicts survival and adjuvant TACE response in hepatocellular carcinoma.
creatorZhang, Jian ; Jiang, Tian-Yi ; Jiang, Bei-Ge ; Yang, Chun ; Tan, Ye-Xiong ; Yang, Ning ; Pan, Yu-Fei ; Ding, Zhi-Wen ; Yang, Guang-Zhen ; Wu, Meng-Chao ; Dong, Li-Wei ; Wang, Hong-Yang
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ispartofOncotarget, February 20, 2015, Vol.6(5), pp.3432-3442
identifierE-ISSN: 1949-2553
subjectAdult–Analysis ; Aged–Chemistry ; Biomarkers, Tumor–Mortality ; Carcinoma, Hepatocellular–Pathology ; Chemoembolization, Therapeutic–Therapy ; Chemotherapy, Adjuvant–Analysis ; Disease-Free Survival–Chemistry ; Female–Mortality ; Hepatectomy–Pathology ; Humans–Therapy ; Immunohistochemistry–Therapy ; Intracellular Signaling Peptides and Proteins–Therapy ; Kaplan-Meier Estimate–Therapy ; Liver Neoplasms–Therapy ; Male–Therapy ; Middle Aged–Therapy ; Multivariate Analysis–Therapy ; Neoplasm Recurrence, Local–Therapy ; Patient Selection–Therapy ; Predictive Value of Tests–Therapy ; Proportional Hazards Models–Therapy ; Risk Factors–Therapy ; Time Factors–Therapy ; Treatment Outcome–Therapy ; Young Adult–Therapy ; Biomarkers, Tumor ; Intracellular Signaling Peptides and Proteins ; Uri1 Protein, Human
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descriptionAdjuvant transcatheter arterial chemoembolization (TACE) protects against hepatocellular carcinoma (HCC) and is associated with reduced disease recurrence and improved outcome after surgery. However, deterioration of liver function after TACE negatively impacts the patient prognosis and limits it use as an option to prolong survival. We analyzed two independent cohorts that included a total of 510 patients with HCC who had undergone tumor resection. Immunohistochemistry assay was used to measure RPB5-mediating protein (RMP) expression and assessed their association with recurrence rate and response to therapy with adjuvant TACE. In patients with HCC, the expression of RMP in tumor is associated with age, gender, tumor size, portal venous invasion, TNM stages, BCLC stages and overall survival. Among patients with high RMP expression, adjuvant TACE after resection was associated with early recurrence. Even in the patients with small tumor size (no more than 5 cm) or no venous invasion, RMP...
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titleRMP predicts survival and adjuvant TACE response in hepatocellular carcinoma.
authorZhang, Jian ; Jiang, Tian-Yi ; Jiang, Bei-Ge ; Yang, Chun ; Tan, Ye-Xiong ; Yang, Ning ; Pan, Yu-Fei ; Ding, Zhi-Wen ; Yang, Guang-Zhen ; Wu, Meng-Chao ; Dong, Li-Wei ; Wang, Hong-Yang
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date2015-02-20