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Regulation of Lipid Droplet Size in Mammary Epithelial Cells by Remodeling of Membrane Lipid Composition—A Potential Mechanism

Milk fat globule size is determined by the size of its precursors—intracellular lipid droplets—and is tightly associated with its composition. We examined the relationship between phospholipid composition of mammary epithelial cells and the size of both intracellular and secreted milk fat globules.... Full description

Journal Title: PLoS One Mar 2015, Vol.10(3), p.e0121645
Main Author: Bat-Chen, Cohen
Other Authors: Shamay, Avi , Argov-Argaman, Nurit
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 19326203 ; DOI: 10.1371/journal.pone.0121645
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title: Regulation of Lipid Droplet Size in Mammary Epithelial Cells by Remodeling of Membrane Lipid Composition—A Potential Mechanism
format: Article
creator:
  • Bat-Chen, Cohen
  • Shamay, Avi
  • Argov-Argaman, Nurit
subjects:
  • Israel
  • Jerusalem Israel
  • Phosphatidylethanolamine
  • Lipid Composition
  • Fatty Acids
  • Biosynthesis
  • Cell Culture
  • Milk Fat Globule Membranes
  • Triglycerides
  • Fatty Acids
  • Metabolism
  • Phospholipid Composition
  • Genomics
  • Lipids
  • Palmitic Acid
  • Mitochondria
  • Rodents
  • Oils & Fats
  • Droplets
ispartof: PLoS One, Mar 2015, Vol.10(3), p.e0121645
description: Milk fat globule size is determined by the size of its precursors—intracellular lipid droplets—and is tightly associated with its composition. We examined the relationship between phospholipid composition of mammary epithelial cells and the size of both intracellular and secreted milk fat globules. Primary culture of mammary epithelial cells was cultured in medium without free fatty acids (control) or with 0.1 mM free capric, palmitic or oleic acid for 24 h. The amount and composition of the cellular lipids and the size of the lipid droplets were determined in the cells and medium. Mitochondrial quantity and expression levels of genes associated with mitochondrial biogenesis and polar lipid composition were determined. Cells cultured with oleic and palmitic acids contained similar quantities of triglycerides, 3.1- and 3.8-fold higher than in controls, respectively (P 3 μm) and phosphatidylethanolamine...
language: eng
source:
identifier: E-ISSN: 19326203 ; DOI: 10.1371/journal.pone.0121645
fulltext: fulltext_linktorsrc
issn:
  • 19326203
  • 1932-6203
url: Link


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titleRegulation of Lipid Droplet Size in Mammary Epithelial Cells by Remodeling of Membrane Lipid Composition—A Potential Mechanism
creatorBat-Chen, Cohen ; Shamay, Avi ; Argov-Argaman, Nurit
ispartofPLoS One, Mar 2015, Vol.10(3), p.e0121645
identifierE-ISSN: 19326203 ; DOI: 10.1371/journal.pone.0121645
subjectIsrael ; Jerusalem Israel ; Phosphatidylethanolamine ; Lipid Composition ; Fatty Acids ; Biosynthesis ; Cell Culture ; Milk Fat Globule Membranes ; Triglycerides ; Fatty Acids ; Metabolism ; Phospholipid Composition ; Genomics ; Lipids ; Palmitic Acid ; Mitochondria ; Rodents ; Oils & Fats ; Droplets
descriptionMilk fat globule size is determined by the size of its precursors—intracellular lipid droplets—and is tightly associated with its composition. We examined the relationship between phospholipid composition of mammary epithelial cells and the size of both intracellular and secreted milk fat globules. Primary culture of mammary epithelial cells was cultured in medium without free fatty acids (control) or with 0.1 mM free capric, palmitic or oleic acid for 24 h. The amount and composition of the cellular lipids and the size of the lipid droplets were determined in the cells and medium. Mitochondrial quantity and expression levels of genes associated with mitochondrial biogenesis and polar lipid composition were determined. Cells cultured with oleic and palmitic acids contained similar quantities of triglycerides, 3.1- and 3.8-fold higher than in controls, respectively (P 3 μm) and phosphatidylethanolamine...
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descriptionMilk fat globule size is determined by the size of its precursors—intracellular lipid droplets—and is tightly associated with its composition. We examined the relationship between phospholipid composition of mammary epithelial cells and the size of both intracellular and secreted milk fat globules. Primary culture of mammary epithelial cells was cultured in medium without free fatty acids (control) or with 0.1 mM free capric, palmitic or oleic acid for 24 h. The amount and composition of the cellular lipids and the size of the lipid droplets were determined in the cells and medium. Mitochondrial quantity and expression levels of genes associated with mitochondrial biogenesis and polar lipid composition were determined. Cells cultured with oleic and palmitic acids contained similar quantities of triglycerides, 3.1- and 3.8-fold higher than in controls, respectively (P 3 μm) and phosphatidylethanolamine...
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abstractMilk fat globule size is determined by the size of its precursors—intracellular lipid droplets—and is tightly associated with its composition. We examined the relationship between phospholipid composition of mammary epithelial cells and the size of both intracellular and secreted milk fat globules. Primary culture of mammary epithelial cells was cultured in medium without free fatty acids (control) or with 0.1 mM free capric, palmitic or oleic acid for 24 h. The amount and composition of the cellular lipids and the size of the lipid droplets were determined in the cells and medium. Mitochondrial quantity and expression levels of genes associated with mitochondrial biogenesis and polar lipid composition were determined. Cells cultured with oleic and palmitic acids contained similar quantities of triglycerides, 3.1- and 3.8-fold higher than in controls, respectively (P 3 μm) and phosphatidylethanolamine...
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