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Brain structure and function as mediators of the effects of amyloid on memory.

OBJECTIVEThe objective of this study was to test whether effects of β-amyloid (Aβ) pathology on episodic memory were mediated by metabolism and gray matter volume in the early stages of Alzheimer disease. METHODSThis was a prospective cohort study. We measured baseline Aβ (using florbetapir-PET), br... Full description

Journal Title: Neurology March 17, 2015, Vol.84(11), pp.1136-1144
Main Author: Mattsson, Niklas
Other Authors: Insel, Philip S , Aisen, Paul S , Jagust, William , Mackin, Scott , Weiner, Michael , Mattsson, Niklas
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1526-632X ; DOI: 10.1212/WNL.0000000000001375
Link: http://search.proquest.com/docview/1664444002/?pq-origsite=primo
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title: Brain structure and function as mediators of the effects of amyloid on memory.
format: Article
creator:
  • Mattsson, Niklas
  • Insel, Philip S
  • Aisen, Paul S
  • Jagust, William
  • Mackin, Scott
  • Weiner, Michael
  • Mattsson, Niklas
subjects:
  • Aged–Analysis
  • Aged, 80 and Over–Metabolism
  • Amyloid Beta-Peptides–Diagnostic Imaging
  • Brain–Physiology
  • Cohort Studies–Physiology
  • Female–Physiology
  • Follow-Up Studies–Physiology
  • Humans–Physiology
  • Male–Physiology
  • Memory, Episodic–Physiology
  • Middle Aged–Physiology
  • Prospective Studies–Physiology
  • Radionuclide Imaging–Physiology
  • Abridged
  • Amyloid Beta-Peptides
ispartof: Neurology, March 17, 2015, Vol.84(11), pp.1136-1144
description: OBJECTIVEThe objective of this study was to test whether effects of β-amyloid (Aβ) pathology on episodic memory were mediated by metabolism and gray matter volume in the early stages of Alzheimer disease. METHODSThis was a prospective cohort study. We measured baseline Aβ (using florbetapir-PET), brain function (using fluorodeoxyglucose-PET), and brain structure (using MRI). A mediation analysis was performed to test whether statistical effects of Aβ positivity on cross-sectional and longitudinal episodic memory were mediated by hypometabolism or regional gray matter volume in cognitively healthy controls (CN, n = 280) and mild cognitive impairment (MCI, n = 463). RESULTSLower memory scores were associated with Aβ positivity (CN, mildly; MCI, strongly), smaller gray matter volumes (CN, few regions, including hippocampus; MCI, widespread), and hypometabolism. Smaller volumes and hypometabolism mediated effects of Aβ in MCI but not in CN. The strongest individual regions mediated up to approximately...
language: eng
source:
identifier: E-ISSN: 1526-632X ; DOI: 10.1212/WNL.0000000000001375
fulltext: fulltext
issn:
  • 1526632X
  • 1526-632X
url: Link


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titleBrain structure and function as mediators of the effects of amyloid on memory.
creatorMattsson, Niklas ; Insel, Philip S ; Aisen, Paul S ; Jagust, William ; Mackin, Scott ; Weiner, Michael ; Mattsson, Niklas
contributorWeiner, Michael (correspondence author) ; Aisen, Paul (record owner) ; Weiner, Michael ; Aisen, Paul ; Petersen, Ronald ; Jack, Clifford R ; Jagust, William ; Trojanowki, John Q ; Toga, Arthur W ; Beckett, Laurel ; Green, Robert C ; Saykin, Andrew J ; Morris, John ; Liu, Enchi ; Green, Robert C ; Montine, Tom ; Petersen, Ronald ; Aisen, Paul ; Gamst, Anthony ; Thomas
ispartofNeurology, March 17, 2015, Vol.84(11), pp.1136-1144
identifierE-ISSN: 1526-632X ; DOI: 10.1212/WNL.0000000000001375
subjectAged–Analysis ; Aged, 80 and Over–Metabolism ; Amyloid Beta-Peptides–Diagnostic Imaging ; Brain–Physiology ; Cohort Studies–Physiology ; Female–Physiology ; Follow-Up Studies–Physiology ; Humans–Physiology ; Male–Physiology ; Memory, Episodic–Physiology ; Middle Aged–Physiology ; Prospective Studies–Physiology ; Radionuclide Imaging–Physiology ; Abridged ; Amyloid Beta-Peptides
descriptionOBJECTIVEThe objective of this study was to test whether effects of β-amyloid (Aβ) pathology on episodic memory were mediated by metabolism and gray matter volume in the early stages of Alzheimer disease. METHODSThis was a prospective cohort study. We measured baseline Aβ (using florbetapir-PET), brain function (using fluorodeoxyglucose-PET), and brain structure (using MRI). A mediation analysis was performed to test whether statistical effects of Aβ positivity on cross-sectional and longitudinal episodic memory were mediated by hypometabolism or regional gray matter volume in cognitively healthy controls (CN, n = 280) and mild cognitive impairment (MCI, n = 463). RESULTSLower memory scores were associated with Aβ positivity (CN, mildly; MCI, strongly), smaller gray matter volumes (CN, few regions, including hippocampus; MCI, widespread), and hypometabolism. Smaller volumes and hypometabolism mediated effects of Aβ in MCI but not in CN. The strongest individual regions mediated up to approximately...
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titleBrain structure and function as mediators of the effects of amyloid on memory.
descriptionOBJECTIVEThe objective of this study was to test whether effects of β-amyloid (Aβ) pathology on episodic memory were mediated by metabolism and gray matter volume in the early stages of Alzheimer disease. METHODSThis was a prospective cohort study. We measured baseline Aβ (using florbetapir-PET), brain function (using fluorodeoxyglucose-PET), and brain structure (using MRI). A mediation analysis was performed to test whether statistical effects of Aβ positivity on cross-sectional and longitudinal episodic memory were mediated by hypometabolism or regional gray matter volume in cognitively healthy controls (CN, n = 280) and mild cognitive impairment (MCI, n = 463). RESULTSLower memory scores were associated with Aβ positivity (CN, mildly; MCI, strongly), smaller gray matter volumes (CN, few regions, including hippocampus; MCI, widespread), and hypometabolism. Smaller volumes and hypometabolism mediated effects of Aβ in MCI but not in CN. The strongest individual regions mediated up to approximately...
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11Prospective Studies–Physiology
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9Saykin, Andrew J
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13Gamst, Anthony
14Thomas, Ronald G
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16Walter, Sarah
17Gessert, Devon
18Sather, Tamie
19Harvey, Danielle
20Kornak, John
21Dale, Anders
22Bernstein, Matthew
23Felmlee, Joel
24Fox, Nick
25Thompson, Paul
26Schuff, Norbert
27Alexander, Gene
28Decarli, Charles
29Bandy, Dan
30Koeppe, Robert A
31Foster, Norm
32Reiman, Eric M
33Chen, Kewei
34Mathis, Chet
35Cairns, Nigel J
36Taylor-Reinwald, Lisa
37Trojanowki, J Q
38Shaw, Les
39Lee, Virginia M Y
40Korecka, Magdalena
41Crawford, Karen
42Neu, Scott
43Foroud, Tatiana M
44Potkin, Steven
45Shen, Li
46Kachaturian, Zaven
47Frank, Richard
48Snyder, Peter J
49Molchan, Susan
50Kaye, Jeffrey
51Quinn, Joseph
52Lind, Betty
53Dolen, Sara
54Schneider, Lon S
55Pawluczyk, Sonia
56Spann, Bryan M
57Brewer, James
58Vanderswag, Helen
59Heidebrink, Judith L
60Lord, Joanne L
61Johnson, Kris
62Doody, Rachelle S
63Villanueva-Meyer, Javier
64Chowdhury, Munir
65Stern, Yaakov
66Honig, Lawrence S
67Bell, Karen L
68Morris, John C
69Ances, Beau
70Carroll, Maria
71Leon, Sue
72Mintun, Mark A
73Schneider, Stacy
74Marson, Daniel
75Griffith, Randall
76Clark, David
77Grossman, Hillel
78Mitsis, Effie
79Romirowsky, Aliza
80Detoledo-Morrell, Leyla
81Shah, Raj C
82Duara, Ranjan
83Varon, Daniel
84Roberts, Peggy
85Albert, Marilyn
86Onyike, Chiadi
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90Glodzik, Lidia
91De Santi, Susan
92Doraiswamy, P Murali
93Petrella, Jeffrey R
94Coleman, R Edward
95Arnold, Steven E
96Karlawish, Jason H
97Wolk, David
98Smith, Charles D
99Jicha, Greg
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titleBrain structure and function as mediators of the effects of amyloid on memory.
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7Humans–Physiology
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1Insel, Philip S
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4Mackin, Scott
5Weiner, Michael
6Aisen, Paul
7Petersen, Ronald
8Jack, Clifford R
9Trojanowki, John Q
10Toga, Arthur W
11Beckett, Laurel
12Green, Robert C
13Saykin, Andrew J
14Morris, John
15Liu, Enchi
16Montine, Tom
17Gamst, Anthony
18Thomas, Ronald G
19Donohue, Michael
20Walter, Sarah
21Gessert, Devon
22Sather, Tamie
23Harvey, Danielle
24Kornak, John
25Dale, Anders
26Bernstein, Matthew
27Felmlee, Joel
28Fox, Nick
29Thompson, Paul
30Schuff, Norbert
31Alexander, Gene
32Decarli, Charles
33Bandy, Dan
34Koeppe, Robert A
35Foster, Norm
36Reiman, Eric M
37Chen, Kewei
38Mathis, Chet
39Cairns, Nigel J
40Taylor-Reinwald, Lisa
41Trojanowki, J Q
42Shaw, Les
43Lee, Virginia M Y
44Korecka, Magdalena
45Crawford, Karen
46Neu, Scott
47Foroud, Tatiana M
48Potkin, Steven
49Shen, Li
50Kachaturian, Zaven
51Frank, Richard
52Snyder, Peter J
53Molchan, Susan
54Kaye, Jeffrey
55Quinn, Joseph
56Lind, Betty
57Dolen, Sara
58Schneider, Lon S
59Pawluczyk, Sonia
60Spann, Bryan M
61Brewer, James
62Vanderswag, Helen
63Heidebrink, Judith L
64Lord, Joanne L
65Johnson, Kris
66Doody, Rachelle S
67Villanueva-Meyer, Javier
68Chowdhury, Munir
69Stern, Yaakov
70Honig, Lawrence S
71Bell, Karen L
72Morris, John C
73Ances, Beau
74Carroll, Maria
75Leon, Sue
76Mintun, Mark A
77Schneider, Stacy
78Marson, Daniel
79Griffith, Randall
80Clark, David
81Grossman, Hillel
82Mitsis, Effie
83Romirowsky, Aliza
84Detoledo-Morrell, Leyla
85Shah, Raj C
86Duara, Ranjan
87Varon, Daniel
88Roberts, Peggy
89Albert, Marilyn
90Onyike, Chiadi
91Kielb, Stephanie
92Rusinek, Henry
93de Leon, Mony J
94Glodzik, Lidia
95De Santi, Susan
96Doraiswamy, P Murali
97Petrella, Jeffrey R
98Coleman, R Edward
99Arnold, Steven E
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9Saykin, Andrew J
10Morris, John
11Liu, Enchi
12Montine, Tom
13Gamst, Anthony
14Thomas, Ronald G
15Donohue, Michael
16Walter, Sarah
17Gessert, Devon
18Sather, Tamie
19Harvey, Danielle
20Kornak, John
21Dale, Anders
22Bernstein, Matthew
23Felmlee, Joel
24Fox, Nick
25Thompson, Paul
26Schuff, Norbert
27Alexander, Gene
28DeCarli, Charles
29Bandy, Dan
30Koeppe, Robert A
31Foster, Norm
32Reiman, Eric M
33Chen, Kewei
34Mathis, Chet
35Cairns, Nigel J
36Taylor-Reinwald, Lisa
37Trojanowki, J Q
38Shaw, Les
39Lee, Virginia M Y
40Korecka, Magdalena
41Crawford, Karen
42Neu, Scott
43Foroud, Tatiana M
44Potkin, Steven
45Shen, Li
46Kachaturian, Zaven
47Frank, Richard
48Snyder, Peter J
49Molchan, Susan
50Kaye, Jeffrey
51Quinn, Joseph
52Lind, Betty
53Dolen, Sara
54Schneider, Lon S
55Pawluczyk, Sonia
56Spann, Bryan M
57Brewer, James
58Vanderswag, Helen
59Heidebrink, Judith L
60Lord, Joanne L
61Johnson, Kris
62Doody, Rachelle S
63Villanueva-Meyer, Javier
64Chowdhury, Munir
65Stern, Yaakov
66Honig, Lawrence S
67Bell, Karen L
68Morris, John C
69Ances, Beau
70Carroll, Maria
71Leon, Sue
72Mintun, Mark A
73Schneider, Stacy
74Marson, Daniel
75Griffith, Randall
76Clark, David
77Grossman, Hillel
78Mitsis, Effie
79Romirowsky, Aliza
80deToledo-Morrell, Leyla
81Shah, Raj C
82Duara, Ranjan
83Varon, Daniel
84Roberts, Peggy
85Albert, Marilyn
86Onyike, Chiadi
87Kielb, Stephanie
88Rusinek, Henry
89de Leon, Mony J
90Glodzik, Lidia
91De Santi, Susan
92Doraiswamy, P Murali
93Petrella, Jeffrey R
94Coleman, R Edward
95Arnold, Steven E
96Karlawish, Jason H
97Wolk, David
98Smith, Charles D
99Jicha, Greg
100...
atitleBrain structure and function as mediators of the effects of amyloid on memory.
jtitleNeurology
risdate20150317
volume84
issue11
spage1136
epage1144
pages1136-1144
eissn1526-632X
formatjournal
genrearticle
ristypeJOUR
abstractOBJECTIVEThe objective of this study was to test whether effects of β-amyloid (Aβ) pathology on episodic memory were mediated by metabolism and gray matter volume in the early stages of Alzheimer disease. METHODSThis was a prospective cohort study. We measured baseline Aβ (using florbetapir-PET), brain function (using fluorodeoxyglucose-PET), and brain structure (using MRI). A mediation analysis was performed to test whether statistical effects of Aβ positivity on cross-sectional and longitudinal episodic memory were mediated by hypometabolism or regional gray matter volume in cognitively healthy controls (CN, n = 280) and mild cognitive impairment (MCI, n = 463). RESULTSLower memory scores were associated with Aβ positivity (CN, mildly; MCI, strongly), smaller gray matter volumes (CN, few regions, including hippocampus; MCI, widespread), and hypometabolism. Smaller volumes and hypometabolism mediated effects of Aβ in MCI but not in CN. The strongest individual regions mediated up to approximately...
doi10.1212/WNL.0000000000001375
urlhttp://search.proquest.com/docview/1664444002/
issn00283878
date2015-03-17