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Development of a capillary electrophoretic method for determination of plasma clearance of iohexol in dogs and cats.

To purchase or authenticate to the full-text of this article, please visit this link: http://onlinelibrary.wiley.com/doi/10.1002/bmc.3304/abstract Byline: Alexander Hellqvist, Reidun Heiene, Siegrid De Baere, Siska Croubels,Ylva Hedeland Abstract Renal function can be monitored by estimation of the... Full description

Journal Title: Biomedical chromatography : BMC April 2015, Vol.29(4), pp.504-513
Main Author: Hellqvist, Alexander
Other Authors: Heiene, Reidun , De Baere, Siegrid , Croubels, Siska , Hedeland, Ylva
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1099-0801 ; DOI: 10.1002/bmc.3304
Link: http://search.proquest.com/docview/1667345902/?pq-origsite=primo
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recordid: proquest1667345902
title: Development of a capillary electrophoretic method for determination of plasma clearance of iohexol in dogs and cats.
format: Article
creator:
  • Hellqvist, Alexander
  • Heiene, Reidun
  • De Baere, Siegrid
  • Croubels, Siska
  • Hedeland, Ylva
subjects:
  • Animals–Blood
  • Biomarkers–Chemistry
  • Cats–Methods
  • Dogs–Pharmacokinetics
  • Electrophoresis, Capillary–Chemistry
  • Glomerular Filtration Rate–Physiology
  • Iohexol–Chemistry
  • Kidney–Chemistry
  • Male–Chemistry
  • Plasma–Chemistry
  • Biomarkers
  • Iohexol
  • Omnipaque®
  • Bioanalytical Method Validation
  • Glomerular Filtration Rate
  • Iohexol
  • Iopromide
ispartof: Biomedical chromatography : BMC, April 2015, Vol.29(4), pp.504-513
description: To purchase or authenticate to the full-text of this article, please visit this link: http://onlinelibrary.wiley.com/doi/10.1002/bmc.3304/abstract Byline: Alexander Hellqvist, Reidun Heiene, Siegrid De Baere, Siska Croubels,Ylva Hedeland Abstract Renal function can be monitored by estimation of the glomerular filtration rate (GFR), for example, through measurement of the plasma clearance of a marker that is freely filtrated through the kidney without reabsorption. It has been proposed that iohexol is the most accurate marker for GFR determination in cats and dogs. However, there is a need for a validated capillary electrophoretic method that covers the concentration range for a full curve clearance estimate of iohexol. In the final method, the plasma samples were protein precipitated and the supernatant was analyzed in a background electrolyte containing borate buffer (0.06 m, pH 10.0). The method developed was proved to be linear (concentration range 18- 2900 mg/L) and had a good precision (e.g. 2.3-2.9% at 88 mg/L) and accuracy (e.g. 101-105% at 88 mg/L). Finally, the method was compared with a previously published and validated HPLC-UV method by parallel analysis of clinical plasma samples from dogs and cats administered Omnipaque[R]. This comparison showed excellent agreement between the two methods and no proportional or systematic error was observed. The proposed method is simple and has a low cost per sample, which makes it applicable for routine analysis. Copyright [c] 2014 John Wiley & Sons, Ltd. CAPTION(S): Supporting info item Supporting info item
language: eng
source:
identifier: E-ISSN: 1099-0801 ; DOI: 10.1002/bmc.3304
fulltext: fulltext
issn:
  • 10990801
  • 1099-0801
url: Link


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titleDevelopment of a capillary electrophoretic method for determination of plasma clearance of iohexol in dogs and cats.
creatorHellqvist, Alexander ; Heiene, Reidun ; De Baere, Siegrid ; Croubels, Siska ; Hedeland, Ylva
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subjectAnimals–Blood ; Biomarkers–Chemistry ; Cats–Methods ; Dogs–Pharmacokinetics ; Electrophoresis, Capillary–Chemistry ; Glomerular Filtration Rate–Physiology ; Iohexol–Chemistry ; Kidney–Chemistry ; Male–Chemistry ; Plasma–Chemistry ; Biomarkers ; Iohexol ; Omnipaque® ; Bioanalytical Method Validation ; Glomerular Filtration Rate ; Iohexol ; Iopromide
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descriptionTo purchase or authenticate to the full-text of this article, please visit this link: http://onlinelibrary.wiley.com/doi/10.1002/bmc.3304/abstract Byline: Alexander Hellqvist, Reidun Heiene, Siegrid De Baere, Siska Croubels,Ylva Hedeland Abstract Renal function can be monitored by estimation of the glomerular filtration rate (GFR), for example, through measurement of the plasma clearance of a marker that is freely filtrated through the kidney without reabsorption. It has been proposed that iohexol is the most accurate marker for GFR determination in cats and dogs. However, there is a need for a validated capillary electrophoretic method that covers the concentration range for a full curve clearance estimate of iohexol. In the final method, the plasma samples were protein precipitated and the supernatant was analyzed in a background electrolyte containing borate buffer (0.06 m, pH 10.0). The method developed was proved to be linear (concentration range 18- 2900 mg/L) and had a good precision (e.g. 2.3-2.9% at 88 mg/L) and accuracy (e.g. 101-105% at 88 mg/L). Finally, the method was compared with a previously published and validated HPLC-UV method by parallel analysis of clinical plasma samples from dogs and cats administered Omnipaque[R]. This comparison showed excellent agreement between the two methods and no proportional or systematic error was observed. The proposed method is simple and has a low cost per sample, which makes it applicable for routine analysis. Copyright [c] 2014 John Wiley & Sons, Ltd. CAPTION(S): Supporting info item Supporting info item
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titleDevelopment of a capillary electrophoretic method for determination of plasma clearance of iohexol in dogs and cats.
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titleDevelopment of a capillary electrophoretic method for determination of plasma clearance of iohexol in dogs and cats.
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