schliessen

Filtern

 

Bibliotheken

Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity.

Circular RNAs (circRNAs) have re-emerged as an interesting RNA species. Here, by deep RNA profiling in different mouse tissues, we observed that circRNAs are significantly enriched in brain.and a disproportionate fraction of them is derived from host genes that code for synaptic proteins. Moreover,... Full description

Journal Title: Nature neuroscience April 2015, Vol.18(4), pp.603-610
Main Author: You, Xintian
Other Authors: Vlatkovic, Irena , Babic, Ana , Will, Tristan , Epstein, Irina , Tushev, Georgi , Akbalik, Güney , Wang, Mantian , Glock, Caspar , Quedenau, Claudia , Wang, Xi , Hou, Jingyi , Liu, Hongyu , Sun, Wei , Sambandan, Sivakumar , Chen, Tao , Schuman, Erin M , Chen, Wei
Format: Electronic Article Electronic Article
Language: English
Subjects:
RNA
ID: E-ISSN: 1546-1726 ; DOI: 10.1038/nn.3975
Link: http://search.proquest.com/docview/1667347104/?pq-origsite=primo
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: proquest1667347104
title: Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity.
format: Article
creator:
  • You, Xintian
  • Vlatkovic, Irena
  • Babic, Ana
  • Will, Tristan
  • Epstein, Irina
  • Tushev, Georgi
  • Akbalik, Güney
  • Wang, Mantian
  • Glock, Caspar
  • Quedenau, Claudia
  • Wang, Xi
  • Hou, Jingyi
  • Liu, Hongyu
  • Sun, Wei
  • Sambandan, Sivakumar
  • Chen, Tao
  • Schuman, Erin M
  • Chen, Wei
subjects:
  • Animals–Growth & Development
  • Brain–Metabolism
  • Dendrites–Metabolism
  • Female–Metabolism
  • Hippocampus–Physiology
  • In Situ Hybridization–Metabolism
  • Male–Metabolism
  • Mice–Genetics
  • Mice, Inbred C57bl–Genetics
  • Neuronal Plasticity–Genetics
  • Neuropil–Genetics
  • Patch-Clamp Techniques–Genetics
  • RNA–Genetics
  • Rats–Genetics
  • Rats, Sprague-Dawley–Genetics
  • Reverse Transcriptase Polymerase Chain Reaction–Genetics
  • Sequence Analysis, RNA–Genetics
  • Synapses–Genetics
  • RNA, Circular
  • RNA
ispartof: Nature neuroscience, April 2015, Vol.18(4), pp.603-610
description: Circular RNAs (circRNAs) have re-emerged as an interesting RNA species. Here, by deep RNA profiling in different mouse tissues, we observed that circRNAs are significantly enriched in brain.and a disproportionate fraction of them is derived from host genes that code for synaptic proteins. Moreover, based on separate profiling of the RNAs localized in neuronal cell bodies and neuropil, on average, circRNAs are more enriched in the neuropil than their host gene mRNA isoforms. Using high resolution in situ hybridization we, for the first time, visualized circRNA punctae in the dendrites of neurons. Consistent with the idea that circRNAs might regulate synaptic function, during development, many circRNAs change their abundance abruptly at a time corresponding to synaptogenesis. In addition, following a homeostatic downscaling of neuronal activity many circRNAs exhibit significant up or down-regulation. Together, our data indicate that brain circRNAs are positioned to respond to and regulate synaptic function.
language: eng
source:
identifier: E-ISSN: 1546-1726 ; DOI: 10.1038/nn.3975
fulltext: fulltext
issn:
  • 15461726
  • 1546-1726
url: Link


@attributes
ID784129136
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid1667347104
sourceidproquest
recordidTN_proquest1667347104
sourcesystemPC
pqid1667347104
galeid408784503
display
typearticle
titleNeural circular RNAs are derived from synaptic genes and regulated by development and plasticity.
creatorYou, Xintian ; Vlatkovic, Irena ; Babic, Ana ; Will, Tristan ; Epstein, Irina ; Tushev, Georgi ; Akbalik, Güney ; Wang, Mantian ; Glock, Caspar ; Quedenau, Claudia ; Wang, Xi ; Hou, Jingyi ; Liu, Hongyu ; Sun, Wei ; Sambandan, Sivakumar ; Chen, Tao ; Schuman, Erin M ; Chen, Wei
contributorYou, Xintian (correspondence author) ; You, Xintian (record owner)
ispartofNature neuroscience, April 2015, Vol.18(4), pp.603-610
identifierE-ISSN: 1546-1726 ; DOI: 10.1038/nn.3975
subjectAnimals–Growth & Development ; Brain–Metabolism ; Dendrites–Metabolism ; Female–Metabolism ; Hippocampus–Physiology ; In Situ Hybridization–Metabolism ; Male–Metabolism ; Mice–Genetics ; Mice, Inbred C57bl–Genetics ; Neuronal Plasticity–Genetics ; Neuropil–Genetics ; Patch-Clamp Techniques–Genetics ; RNA–Genetics ; Rats–Genetics ; Rats, Sprague-Dawley–Genetics ; Reverse Transcriptase Polymerase Chain Reaction–Genetics ; Sequence Analysis, RNA–Genetics ; Synapses–Genetics ; RNA, Circular ; RNA
languageeng
source
descriptionCircular RNAs (circRNAs) have re-emerged as an interesting RNA species. Here, by deep RNA profiling in different mouse tissues, we observed that circRNAs are significantly enriched in brain.and a disproportionate fraction of them is derived from host genes that code for synaptic proteins. Moreover, based on separate profiling of the RNAs localized in neuronal cell bodies and neuropil, on average, circRNAs are more enriched in the neuropil than their host gene mRNA isoforms. Using high resolution in situ hybridization we, for the first time, visualized circRNA punctae in the dendrites of neurons. Consistent with the idea that circRNAs might regulate synaptic function, during development, many circRNAs change their abundance abruptly at a time corresponding to synaptogenesis. In addition, following a homeostatic downscaling of neuronal activity many circRNAs exhibit significant up or down-regulation. Together, our data indicate that brain circRNAs are positioned to respond to and regulate synaptic function.
version8
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttp://search.proquest.com/docview/1667347104/?pq-origsite=primo$$EView_record_in_ProQuest_(subscribers_only)
search
creatorcontrib
0You, Xintian
1Vlatkovic, Irena
2Babic, Ana
3Will, Tristan
4Epstein, Irina
5Tushev, Georgi
6Akbalik, Güney
7Wang, Mantian
8Glock, Caspar
9Quedenau, Claudia
10Wang, Xi
11Hou, Jingyi
12Liu, Hongyu
13Sun, Wei
14Sambandan, Sivakumar
15Chen, Tao
16Schuman, Erin M
17Chen, Wei
titleNeural circular RNAs are derived from synaptic genes and regulated by development and plasticity.
subject
0Animals–Growth & Development
1Brain–Metabolism
2Dendrites–Metabolism
3Female–Metabolism
4Hippocampus–Physiology
5In Situ Hybridization–Metabolism
6Male–Metabolism
7Mice–Genetics
8Mice, Inbred C57bl–Genetics
9Neuronal Plasticity–Genetics
10Neuropil–Genetics
11Patch-Clamp Techniques–Genetics ;...
12GSE61991
13GEO
general
0English
110.1038/nn.3975
2MEDLINE (ProQuest)
3ProQuest Biological Science Collection
4ProQuest Natural Science Collection
5ProQuest SciTech Collection
6Biological Science Database
7Natural Science Collection
8SciTech Premium Collection
9Health Research Premium Collection
10Health Research Premium Collection (Alumni edition)
11Biological Science Index (ProQuest)
sourceidproquest
recordidproquest1667347104
issn
015461726
11546-1726
rsrctypearticle
creationdate2015
addtitleNature neuroscience
searchscope
01007527
11007944
21009130
310000004
410000038
510000050
610000120
710000159
810000238
910000253
1010000260
1110000270
1210000271
1310000302
1410000350
15proquest
scope
01007527
11007944
21009130
310000004
410000038
510000050
610000120
710000159
810000238
910000253
1010000260
1110000270
1210000271
1310000302
1410000350
15proquest
lsr43
01007527false
11007944false
21009130false
310000004false
410000038false
510000050false
610000120false
710000159false
810000238false
910000253false
1010000260false
1110000270false
1210000271false
1310000302false
1410000350false
contributorYou, Xintian
startdate20150401
enddate20150401
citationpf 603 pt 610 vol 18 issue 4
lsr30VSR-Enriched:[pqid, galeid, description, issn]
sort
titleNeural circular RNAs are derived from synaptic genes and regulated by development and plasticity.
authorYou, Xintian ; Vlatkovic, Irena ; Babic, Ana ; Will, Tristan ; Epstein, Irina ; Tushev, Georgi ; Akbalik, Güney ; Wang, Mantian ; Glock, Caspar ; Quedenau, Claudia ; Wang, Xi ; Hou, Jingyi ; Liu, Hongyu ; Sun, Wei ; Sambandan, Sivakumar ; Chen, Tao ; Schuman, Erin M ; Chen, Wei
creationdate20150401
lso0120150401
facets
frbrgroupid-7539344315254470838
frbrtype5
newrecords20181218
languageeng
creationdate2015
topic
0Animals–Growth & Development
1Brain–Metabolism
2Dendrites–Metabolism
3Female–Metabolism
4Hippocampus–Physiology
5In Situ Hybridization–Metabolism
6Male–Metabolism
7Mice–Genetics
8Mice, Inbred C57bl–Genetics
9Neuronal Plasticity–Genetics
10Neuropil–Genetics
11Patch-Clamp Techniques–Genetics ;...
collection
0MEDLINE (ProQuest)
1ProQuest Biological Science Collection
2ProQuest Natural Science Collection
3ProQuest SciTech Collection
4Biological Science Database
5Natural Science Collection
6SciTech Premium Collection
7Health Research Premium Collection
8Health Research Premium Collection (Alumni edition)
9Biological Science Index (ProQuest)
prefilterarticles
rsrctypearticles
creatorcontrib
0You, Xintian
1Vlatkovic, Irena
2Babic, Ana
3Will, Tristan
4Epstein, Irina
5Tushev, Georgi
6Akbalik, Güney
7Wang, Mantian
8Glock, Caspar
9Quedenau, Claudia
10Wang, Xi
11Hou, Jingyi
12Liu, Hongyu
13Sun, Wei
14Sambandan, Sivakumar
15Chen, Tao
16Schuman, Erin M
17Chen, Wei
jtitleNature neuroscience
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0You
1Vlatkovic
2Babic
3Will
4Epstein
5Tushev
6Akbalik
7Wang
8Glock
9Quedenau
10Hou
11Liu
12Sun
13Sambandan
14Chen
15Schuman
aufirst
0Xintian
1Irena
2Ana
3Tristan
4Irina
5Georgi
6Güney
7Mantian
8Caspar
9Claudia
10Xi
11Jingyi
12Hongyu
13Wei
14Sivakumar
15Tao
16Erin M
au
0You, Xintian
1Vlatkovic, Irena
2Babic, Ana
3Will, Tristan
4Epstein, Irina
5Tushev, Georgi
6Akbalik, Güney
7Wang, Mantian
8Glock, Caspar
9Quedenau, Claudia
10Wang, Xi
11Hou, Jingyi
12Liu, Hongyu
13Sun, Wei
14Sambandan, Sivakumar
15Chen, Tao
16Schuman, Erin M
17Chen, Wei
addauYou, Xintian
atitleNeural circular RNAs are derived from synaptic genes and regulated by development and plasticity.
jtitleNature neuroscience
risdate20150401
volume18
issue4
spage603
epage610
pages603-610
eissn1546-1726
formatjournal
genrearticle
ristypeJOUR
doi10.1038/nn.3975
urlhttp://search.proquest.com/docview/1667347104/
issn10976256
date2015-04-01