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Progressive thinning of visual cortex in primary open-angle glaucoma of varying severity.

The aim of this study was to investigate possible changes of cortical thickness in the visual cortex in primary open-angle glaucoma (POAG) of varying severity. Twenty normal controls (NC), 20 mild (MP) and 17 severe (SP) POAG patients were recruited and scanned using magnetic resonance imaging. Cort... Full description

Journal Title: PloS one 2015, Vol.10(3), p.e0121960
Main Author: Yu, Longhua
Other Authors: Xie, Liqi , Dai, Chao , Xie, Bing , Liang, Minglong , Zhao, Lu , Yin, Xuntao , Wang, Jian
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0121960
Link: http://search.proquest.com/docview/1667966105/?pq-origsite=primo
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title: Progressive thinning of visual cortex in primary open-angle glaucoma of varying severity.
format: Article
creator:
  • Yu, Longhua
  • Xie, Liqi
  • Dai, Chao
  • Xie, Bing
  • Liang, Minglong
  • Zhao, Lu
  • Yin, Xuntao
  • Wang, Jian
subjects:
  • Adult–Pathology
  • Case-Control Studies–Methods
  • Female–Pathology
  • Glaucoma, Open-Angle–Pathology
  • Humans–Pathology
  • Magnetic Resonance Spectroscopy–Pathology
  • Male–Pathology
  • Middle Aged–Pathology
  • Nerve Fibers–Pathology
  • Visual Cortex–Pathology
  • Visual Fields–Pathology
  • Young Adult–Pathology
ispartof: PloS one, 2015, Vol.10(3), p.e0121960
description: The aim of this study was to investigate possible changes of cortical thickness in the visual cortex in primary open-angle glaucoma (POAG) of varying severity. Twenty normal controls (NC), 20 mild (MP) and 17 severe (SP) POAG patients were recruited and scanned using magnetic resonance imaging. Cortical thickness analyses with regions of interest (V1, V2, ventral V3, V4 and V5/MT+) were used to assess the cortical changes among the three groups. Furthermore, the associations of cortical thickness with retinal nerve fiber layer (RNFL) thickness and mean deviation of visual field were analyzed. Compared with the NC group, decreased cortical thickness was detected in the bilateral V5/MT+ areas in the MP group and the left V1, bilateral V2 and V5/MT+ areas in the SP group. Cortical thinning of the bilateral V2 areas was detected in the SP group compared with the MP group. In addition, cortical thinning of these visual areas was related to the ophthalmologic measurements. In conclusion, POAG patients exhibit cortical thinning in the bilateral V5/MT+ in the early stage of disease. The cortical degeneration in visual areas is discrepant with disease progressing and the dorsal pathway might be selectively damaged in POAG. Therefore, the cortical thinning of these visual areas may play a key role in the progression of POAG and can serve as a novel biomarker for accurately evaluating the severity of POAG.
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0121960
fulltext: fulltext
issn:
  • 19326203
  • 1932-6203
url: Link


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titleProgressive thinning of visual cortex in primary open-angle glaucoma of varying severity.
creatorYu, Longhua ; Xie, Liqi ; Dai, Chao ; Xie, Bing ; Liang, Minglong ; Zhao, Lu ; Yin, Xuntao ; Wang, Jian
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subjectAdult–Pathology ; Case-Control Studies–Methods ; Female–Pathology ; Glaucoma, Open-Angle–Pathology ; Humans–Pathology ; Magnetic Resonance Spectroscopy–Pathology ; Male–Pathology ; Middle Aged–Pathology ; Nerve Fibers–Pathology ; Visual Cortex–Pathology ; Visual Fields–Pathology ; Young Adult–Pathology
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descriptionThe aim of this study was to investigate possible changes of cortical thickness in the visual cortex in primary open-angle glaucoma (POAG) of varying severity. Twenty normal controls (NC), 20 mild (MP) and 17 severe (SP) POAG patients were recruited and scanned using magnetic resonance imaging. Cortical thickness analyses with regions of interest (V1, V2, ventral V3, V4 and V5/MT+) were used to assess the cortical changes among the three groups. Furthermore, the associations of cortical thickness with retinal nerve fiber layer (RNFL) thickness and mean deviation of visual field were analyzed. Compared with the NC group, decreased cortical thickness was detected in the bilateral V5/MT+ areas in the MP group and the left V1, bilateral V2 and V5/MT+ areas in the SP group. Cortical thinning of the bilateral V2 areas was detected in the SP group compared with the MP group. In addition, cortical thinning of these visual areas was related to the ophthalmologic measurements. In conclusion, POAG patients exhibit cortical thinning in the bilateral V5/MT+ in the early stage of disease. The cortical degeneration in visual areas is discrepant with disease progressing and the dorsal pathway might be selectively damaged in POAG. Therefore, the cortical thinning of these visual areas may play a key role in the progression of POAG and can serve as a novel biomarker for accurately evaluating the severity of POAG.
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