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Sublingual Immunization of Trivalent Human Papillomavirus DNA Vaccine in Baculovirus Nanovector for Protection against Vaginal Challenge: e0119408

Here, we report the immunogenicity of a sublingually delivered, trivalent human papillomavirus (HPV) DNA vaccine encapsidated in a human endogenous retrovirus (HERV) envelope-coated, nonreplicable, baculovirus nanovector. The HERV envelope-coated, nonreplicable, baculovirus-based DNA vaccine, encodi... Full description

Journal Title: PLoS ONE Mar 2015, Vol.10(3)
Main Author: Lee, Hee-Jung
Other Authors: Cho, Hansam , Kim, Mi-Gyeong , Heo, Yoon-Ki , Cho, Yeondong , Gwon, Yong-Dae , Park, Ki , Jin, Hyerim , Kim, Jinyoung , Oh, Yu-Kyoung
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0119408
Link: http://search.proquest.com/docview/1668253321/?pq-origsite=primo
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title: Sublingual Immunization of Trivalent Human Papillomavirus DNA Vaccine in Baculovirus Nanovector for Protection against Vaginal Challenge: e0119408
format: Article
creator:
  • Lee, Hee-Jung
  • Cho, Hansam
  • Kim, Mi-Gyeong
  • Heo, Yoon-Ki
  • Cho, Yeondong
  • Gwon, Yong-Dae
  • Park, Ki
  • Jin, Hyerim
  • Kim, Jinyoung
  • Oh, Yu-Kyoung
subjects:
  • Helper Cells
  • Mucosa
  • Oral Administration
  • Adjuvants
  • Imaging
  • Immunization
  • Immunoglobulin A
  • Retrovirus
  • DNA Vaccines
  • Lung
  • Immunogenicity
  • Vagina
  • Lymphocytes T
  • Immunoglobulin G
  • Immune Response
  • Human Papillomavirus 16
  • Human Endogenous Retrovirus
  • Human Papillomavirus 18
  • Baculovirus
  • Human Papillomavirus
ispartof: PLoS ONE, Mar 2015, Vol.10(3)
description: Here, we report the immunogenicity of a sublingually delivered, trivalent human papillomavirus (HPV) DNA vaccine encapsidated in a human endogenous retrovirus (HERV) envelope-coated, nonreplicable, baculovirus nanovector. The HERV envelope-coated, nonreplicable, baculovirus-based DNA vaccine, encoding HPV16L1, -18L1 and -58L1 (AcHERV-triHPV), was constructed and sublingually administered to mice without adjuvant. Following sublingual (SL) administration, AcHERV-triHPV was absorbed and distributed throughout the body. At 15 minutes and 1 day post-dose, the distribution of AcHERV-triHPV to the lung was higher than that to other tissues. At 30 days post-dose, the levels of AcHERV-triHPV had diminished throughout the body. Six weeks after the first of three doses, 1108 copies of SL AcHERV-triHPV induced HPV type-specific serum IgG and neutralizing antibodies to a degree comparable to that of IM immunization with 1109 copies. AcHERV-triHPV induced HPV type-specific vaginal...
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0119408
fulltext: fulltext
issn:
  • 19326203
  • 1932-6203
url: Link


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titleSublingual Immunization of Trivalent Human Papillomavirus DNA Vaccine in Baculovirus Nanovector for Protection against Vaginal Challenge: e0119408
creatorLee, Hee-Jung ; Cho, Hansam ; Kim, Mi-Gyeong ; Heo, Yoon-Ki ; Cho, Yeondong ; Gwon, Yong-Dae ; Park, Ki ; Jin, Hyerim ; Kim, Jinyoung ; Oh, Yu-Kyoung
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ispartofPLoS ONE, Mar 2015, Vol.10(3)
identifierE-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0119408
subjectHelper Cells ; Mucosa ; Oral Administration ; Adjuvants ; Imaging ; Immunization ; Immunoglobulin A ; Retrovirus ; DNA Vaccines ; Lung ; Immunogenicity ; Vagina ; Lymphocytes T ; Immunoglobulin G ; Immune Response ; Human Papillomavirus 16 ; Human Endogenous Retrovirus ; Human Papillomavirus 18 ; Baculovirus ; Human Papillomavirus
descriptionHere, we report the immunogenicity of a sublingually delivered, trivalent human papillomavirus (HPV) DNA vaccine encapsidated in a human endogenous retrovirus (HERV) envelope-coated, nonreplicable, baculovirus nanovector. The HERV envelope-coated, nonreplicable, baculovirus-based DNA vaccine, encoding HPV16L1, -18L1 and -58L1 (AcHERV-triHPV), was constructed and sublingually administered to mice without adjuvant. Following sublingual (SL) administration, AcHERV-triHPV was absorbed and distributed throughout the body. At 15 minutes and 1 day post-dose, the distribution of AcHERV-triHPV to the lung was higher than that to other tissues. At 30 days post-dose, the levels of AcHERV-triHPV had diminished throughout the body. Six weeks after the first of three doses, 1108 copies of SL AcHERV-triHPV induced HPV type-specific serum IgG and neutralizing antibodies to a degree comparable to that of IM immunization with 1109 copies. AcHERV-triHPV induced HPV type-specific vaginal...
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titleSublingual Immunization of Trivalent Human Papillomavirus DNA Vaccine in Baculovirus Nanovector for Protection against Vaginal Challenge: e0119408
descriptionHere, we report the immunogenicity of a sublingually delivered, trivalent human papillomavirus (HPV) DNA vaccine encapsidated in a human endogenous retrovirus (HERV) envelope-coated, nonreplicable, baculovirus nanovector. The HERV envelope-coated, nonreplicable, baculovirus-based DNA vaccine, encoding HPV16L1, -18L1 and -58L1 (AcHERV-triHPV), was constructed and sublingually administered to mice without adjuvant. Following sublingual (SL) administration, AcHERV-triHPV was absorbed and distributed throughout the body. At 15 minutes and 1 day post-dose, the distribution of AcHERV-triHPV to the lung was higher than that to other tissues. At 30 days post-dose, the levels of AcHERV-triHPV had diminished throughout the body. Six weeks after the first of three doses, 1108 copies of SL AcHERV-triHPV induced HPV type-specific serum IgG and neutralizing antibodies to a degree comparable to that of IM immunization with 1109 copies. AcHERV-triHPV induced HPV type-specific vaginal...
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titleSublingual Immunization of Trivalent Human Papillomavirus DNA Vaccine in Baculovirus Nanovector for Protection against Vaginal Challenge: e0119408
authorLee, Hee-Jung ; Cho, Hansam ; Kim, Mi-Gyeong ; Heo, Yoon-Ki ; Cho, Yeondong ; Gwon, Yong-Dae ; Park, Ki ; Jin, Hyerim ; Kim, Jinyoung ; Oh, Yu-Kyoung
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abstractHere, we report the immunogenicity of a sublingually delivered, trivalent human papillomavirus (HPV) DNA vaccine encapsidated in a human endogenous retrovirus (HERV) envelope-coated, nonreplicable, baculovirus nanovector. The HERV envelope-coated, nonreplicable, baculovirus-based DNA vaccine, encoding HPV16L1, -18L1 and -58L1 (AcHERV-triHPV), was constructed and sublingually administered to mice without adjuvant. Following sublingual (SL) administration, AcHERV-triHPV was absorbed and distributed throughout the body. At 15 minutes and 1 day post-dose, the distribution of AcHERV-triHPV to the lung was higher than that to other tissues. At 30 days post-dose, the levels of AcHERV-triHPV had diminished throughout the body. Six weeks after the first of three doses, 1108 copies of SL AcHERV-triHPV induced HPV type-specific serum IgG and neutralizing antibodies to a degree comparable to that of IM immunization with 1109 copies. AcHERV-triHPV induced HPV type-specific vaginal...
doi10.1371/journal.pone.0119408
urlhttp://search.proquest.com/docview/1668253321/
pagese0119408
date2015-03-01