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During Drosophila disc regeneration, JAK/STAT coordinates cell proliferation with Dilp8-mediated developmental delay.

Regeneration of fragmented Drosophila imaginal discs occurs in an epimorphic manner involving local cell proliferation at the wound site. After disc fragmentation, cells at the wound site activate a restoration program through wound healing, regenerative cell proliferation, and repatterning of the t... Full description

Journal Title: Proceedings of the National Academy of Sciences of the United States of America May 5, 2015, Vol.112(18), pp.E2327-E2336
Main Author: Katsuyama, Tomonori
Other Authors: Comoglio, Federico , Seimiya, Makiko , Cabuy, Erik , Paro, Renato
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1091-6490 ; DOI: 10.1073/pnas.1423074112
Link: http://search.proquest.com/docview/1680186414/?pq-origsite=primo
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recordid: proquest1680186414
title: During Drosophila disc regeneration, JAK/STAT coordinates cell proliferation with Dilp8-mediated developmental delay.
format: Article
creator:
  • Katsuyama, Tomonori
  • Comoglio, Federico
  • Seimiya, Makiko
  • Cabuy, Erik
  • Paro, Renato
subjects:
  • Animals–Physiology
  • Body Patterning–Metabolism
  • Cell Lineage–Physiology
  • Cell Proliferation–Metabolism
  • Cluster Analysis–Metabolism
  • Drosophila–Metabolism
  • Drosophila Proteins–Metabolism
  • Gene Expression Regulation–Metabolism
  • Imaginal Discs–Metabolism
  • Intercellular Signaling Peptides and Proteins–Metabolism
  • Janus Kinases–Metabolism
  • Oligonucleotide Array Sequence Analysis–Metabolism
  • Principal Component Analysis–Metabolism
  • Regeneration–Metabolism
  • Stat Transcription Factors–Metabolism
  • Signal Transduction–Metabolism
  • Transcription Factors–Metabolism
  • Transcriptome–Metabolism
  • Wound Healing–Metabolism
  • Drosophila Proteins
  • Intercellular Signaling Peptides and Proteins
  • Stat Transcription Factors
  • Transcription Factors
  • Insulin-Like Peptide 8, Drosophila
  • Janus Kinases
  • Hop Protein, Drosophila
  • Drosophila Imaginal Discs
  • Jak/Stat Signaling
  • Epimorphic Regeneration
ispartof: Proceedings of the National Academy of Sciences of the United States of America, May 5, 2015, Vol.112(18), pp.E2327-E2336
description: Regeneration of fragmented Drosophila imaginal discs occurs in an epimorphic manner involving local cell proliferation at the wound site. After disc fragmentation, cells at the wound site activate a restoration program through wound healing, regenerative cell proliferation, and repatterning of the tissue. However, the interplay of signaling cascades driving these early reprogramming steps is not well-understood. Here, we profiled the transcriptome of regenerating cells in the early phase within 24 h after wounding. We found that JAK/STAT signaling becomes activated at the wound site and promotes regenerative cell proliferation in cooperation with Wingless (Wg) signaling. In addition, we showed that the expression of Drosophila insulin-like peptide 8 (dilp8), which encodes a paracrine peptide to delay the onset of pupariation, is controlled by JAK/STAT signaling in early regenerating discs. Our findings suggest that JAK/STAT signaling plays a pivotal role in coordinating regenerative disc growth with organismal developmental timing.
language: eng
source:
identifier: E-ISSN: 1091-6490 ; DOI: 10.1073/pnas.1423074112
fulltext: fulltext
issn:
  • 10916490
  • 1091-6490
url: Link


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titleDuring Drosophila disc regeneration, JAK/STAT coordinates cell proliferation with Dilp8-mediated developmental delay.
creatorKatsuyama, Tomonori ; Comoglio, Federico ; Seimiya, Makiko ; Cabuy, Erik ; Paro, Renato
contributorKatsuyama, Tomonori (correspondence author) ; Katsuyama, Tomonori (record owner)
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identifierE-ISSN: 1091-6490 ; DOI: 10.1073/pnas.1423074112
subjectAnimals–Physiology ; Body Patterning–Metabolism ; Cell Lineage–Physiology ; Cell Proliferation–Metabolism ; Cluster Analysis–Metabolism ; Drosophila–Metabolism ; Drosophila Proteins–Metabolism ; Gene Expression Regulation–Metabolism ; Imaginal Discs–Metabolism ; Intercellular Signaling Peptides and Proteins–Metabolism ; Janus Kinases–Metabolism ; Oligonucleotide Array Sequence Analysis–Metabolism ; Principal Component Analysis–Metabolism ; Regeneration–Metabolism ; Stat Transcription Factors–Metabolism ; Signal Transduction–Metabolism ; Transcription Factors–Metabolism ; Transcriptome–Metabolism ; Wound Healing–Metabolism ; Drosophila Proteins ; Intercellular Signaling Peptides and Proteins ; Stat Transcription Factors ; Transcription Factors ; Insulin-Like Peptide 8, Drosophila ; Janus Kinases ; Hop Protein, Drosophila ; Drosophila Imaginal Discs ; Jak/Stat Signaling ; Epimorphic Regeneration
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descriptionRegeneration of fragmented Drosophila imaginal discs occurs in an epimorphic manner involving local cell proliferation at the wound site. After disc fragmentation, cells at the wound site activate a restoration program through wound healing, regenerative cell proliferation, and repatterning of the tissue. However, the interplay of signaling cascades driving these early reprogramming steps is not well-understood. Here, we profiled the transcriptome of regenerating cells in the early phase within 24 h after wounding. We found that JAK/STAT signaling becomes activated at the wound site and promotes regenerative cell proliferation in cooperation with Wingless (Wg) signaling. In addition, we showed that the expression of Drosophila insulin-like peptide 8 (dilp8), which encodes a paracrine peptide to delay the onset of pupariation, is controlled by JAK/STAT signaling in early regenerating discs. Our findings suggest that JAK/STAT signaling plays a pivotal role in coordinating regenerative disc growth with organismal developmental timing.
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