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Combining diffusion tensor imaging and gray matter volumetry to investigate motor functioning in chronic stroke.

Motor impairment after stroke is related to the integrity of the corticospinal tract (CST). However, considerable variability in motor impairment remains unexplained. To increase the accuracy in evaluating long-term motor function after ischemic stroke, we tested the hypothesis that combining diffus... Full description

Journal Title: PloS one 2015, Vol.10(5), p.e0125038
Main Author: Yang, Ming
Other Authors: Yang, Ya-Ru , Li, Hui-Jun , Lu, Xue-Song , Shi, Yong-Mei , Liu, Bin , Chen, Hua-Jun , Teng, Gao-Jun , Chen, Rong , Herskovits, Edward H
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0125038
Link: http://search.proquest.com/docview/1680956605/?pq-origsite=primo
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recordid: proquest1680956605
title: Combining diffusion tensor imaging and gray matter volumetry to investigate motor functioning in chronic stroke.
format: Article
creator:
  • Yang, Ming
  • Yang, Ya-Ru
  • Li, Hui-Jun
  • Lu, Xue-Song
  • Shi, Yong-Mei
  • Liu, Bin
  • Chen, Hua-Jun
  • Teng, Gao-Jun
  • Chen, Rong
  • Herskovits, Edward H
subjects:
  • Adult–Methods
  • Aged–Pathology
  • Aged, 80 and Over–Diagnosis
  • Diffusion Tensor Imaging–Diagnosis
  • Female–Diagnosis
  • Gray Matter–Diagnosis
  • Humans–Diagnosis
  • Male–Diagnosis
  • Middle Aged–Diagnosis
  • Movement–Diagnosis
  • Stroke–Diagnosis
ispartof: PloS one, 2015, Vol.10(5), p.e0125038
description: Motor impairment after stroke is related to the integrity of the corticospinal tract (CST). However, considerable variability in motor impairment remains unexplained. To increase the accuracy in evaluating long-term motor function after ischemic stroke, we tested the hypothesis that combining diffusion tensor imaging (DTI) and gray matter (GM) volumetry can better characterize long-term motor deficit than either method alone in patients with chronic stroke. We recruited 31 patients whose Medical Research Council strength grade was [less than or equal to] 3/5 in the extensor muscles of the affected upper extremity in the acute phase. We used the Upper Extremity Fugl-Meyer (UE-FM) assessment to evaluate motor impairment, and as the primary outcome variable. We computed the fractional anisotropy ratio of the entire CST (CST.sub.ratio) and the volume of interest ratio (VOI.sub.ratio ), between ipsilesional and contralesional hemispheres, to explain long-term motor impairment. The results showed that CST.sub.ratio, VOI.sub.ratio of motor-related brain regions, and VOI.sub.ratio in the temporal lobe were correlated with UE-FM. A multiple regression model including CST.sub.ratio and VOI.sub.ratio of the caudate nucleus explained 40.7% of the variability in UE-FM. The adjusted R2 of the regression model with CST.sub.ratio as an independent variable was 29.4%, and that of using VOI.sub.ratio of the caudate nucleus as an independent variable was 23.1%. These results suggest that combining DTI and GM volumetry may achieve better explanation of long-term motor deficit in stroke patients, than using either measure individually. This finding may provide guidance in determining optimal neurorehabilitative interventions.
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0125038
fulltext: fulltext
issn:
  • 19326203
  • 1932-6203
url: Link


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titleCombining diffusion tensor imaging and gray matter volumetry to investigate motor functioning in chronic stroke.
creatorYang, Ming ; Yang, Ya-Ru ; Li, Hui-Jun ; Lu, Xue-Song ; Shi, Yong-Mei ; Liu, Bin ; Chen, Hua-Jun ; Teng, Gao-Jun ; Chen, Rong ; Herskovits, Edward H
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subjectAdult–Methods ; Aged–Pathology ; Aged, 80 and Over–Diagnosis ; Diffusion Tensor Imaging–Diagnosis ; Female–Diagnosis ; Gray Matter–Diagnosis ; Humans–Diagnosis ; Male–Diagnosis ; Middle Aged–Diagnosis ; Movement–Diagnosis ; Stroke–Diagnosis
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descriptionMotor impairment after stroke is related to the integrity of the corticospinal tract (CST). However, considerable variability in motor impairment remains unexplained. To increase the accuracy in evaluating long-term motor function after ischemic stroke, we tested the hypothesis that combining diffusion tensor imaging (DTI) and gray matter (GM) volumetry can better characterize long-term motor deficit than either method alone in patients with chronic stroke. We recruited 31 patients whose Medical Research Council strength grade was [less than or equal to] 3/5 in the extensor muscles of the affected upper extremity in the acute phase. We used the Upper Extremity Fugl-Meyer (UE-FM) assessment to evaluate motor impairment, and as the primary outcome variable. We computed the fractional anisotropy ratio of the entire CST (CST.sub.ratio) and the volume of interest ratio (VOI.sub.ratio ), between ipsilesional and contralesional hemispheres, to explain long-term motor impairment. The results showed that CST.sub.ratio, VOI.sub.ratio of motor-related brain regions, and VOI.sub.ratio in the temporal lobe were correlated with UE-FM. A multiple regression model including CST.sub.ratio and VOI.sub.ratio of the caudate nucleus explained 40.7% of the variability in UE-FM. The adjusted R2 of the regression model with CST.sub.ratio as an independent variable was 29.4%, and that of using VOI.sub.ratio of the caudate nucleus as an independent variable was 23.1%. These results suggest that combining DTI and GM volumetry may achieve better explanation of long-term motor deficit in stroke patients, than using either measure individually. This finding may provide guidance in determining optimal neurorehabilitative interventions.
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