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Comparative toxicokinetics, absolute oral bioavailability, and biotransformation of zearalenone in different poultry species.

After oral (PO) and intravenous (IV) administration of zearalenone (ZEN) to broiler chickens, laying hens, and turkey poults, the mycotoxin was rapidly absorbed (T max = 0.32-0.97 h) in all three species; however, the absolute oral bioavailability was low (F% = 6.87-10.28%). Next, also a rapid elimi... Full description

Journal Title: Journal of agricultural and food chemistry May 27, 2015, Vol.63(20), pp.5092-5098
Main Author: Devreese, Mathias
Other Authors: Antonissen, Gunther , Broekaert, Nathan , De Baere, Siegrid , Vanhaecke, Lynn , De Backer, Patrick , Croubels, Siska
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1520-5118 ; DOI: 1520-5118 ; DOI: 10.1021/acs.jafc.5b01608
Link: http://search.proquest.com/docview/1683754475/?pq-origsite=primo
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recordid: proquest1683754475
title: Comparative toxicokinetics, absolute oral bioavailability, and biotransformation of zearalenone in different poultry species.
format: Article
creator:
  • Devreese, Mathias
  • Antonissen, Gunther
  • Broekaert, Nathan
  • De Baere, Siegrid
  • Vanhaecke, Lynn
  • De Backer, Patrick
  • Croubels, Siska
subjects:
  • Animals–Metabolism
  • Biological Availability–Metabolism
  • Biotransformation–Metabolism
  • Chickens–Pharmacokinetics
  • Female–Pharmacokinetics
  • Toxicokinetics–Pharmacokinetics
  • Turkeys–Pharmacokinetics
  • Zearalenone–Pharmacokinetics
  • Zearalenone
  • Biotransformation
  • Broiler Chicken
  • Laying Hen
  • Poultry
  • Toxicokinetics
  • Turkey
  • Zearalenone
ispartof: Journal of agricultural and food chemistry, May 27, 2015, Vol.63(20), pp.5092-5098
description: After oral (PO) and intravenous (IV) administration of zearalenone (ZEN) to broiler chickens, laying hens, and turkey poults, the mycotoxin was rapidly absorbed (T max = 0.32-0.97 h) in all three species; however, the absolute oral bioavailability was low (F% = 6.87-10.28%). Next, also a rapid elimination of the mycotoxin in all poultry species was observed (T 1/2el = 0.29-0.46 h). Both α- and β-zearalenone (ZEL) were formed equally after IV administration in all species studied, whereas an increased biotransformation to β-ZEL was demonstrated after PO administration, indicating presystemic biotransformation mainly in broiler chickens and laying hens. In comparison to the latter, turkey poults demonstrated a more extensive biotransformation of ZEN to α-ZEL after PO administration which could, in combination with the observed higher volume of distribution of ZEN, indicate a higher sensitivity of this species to the effects of ZEN in comparison to other poultry species. ; p. 5092-5098.
language: eng
source:
identifier: E-ISSN: 1520-5118 ; DOI: 1520-5118 ; DOI: 10.1021/acs.jafc.5b01608
fulltext: no_fulltext
issn:
  • 15205118
  • 1520-5118
url: Link


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titleComparative toxicokinetics, absolute oral bioavailability, and biotransformation of zearalenone in different poultry species.
creatorDevreese, Mathias ; Antonissen, Gunther ; Broekaert, Nathan ; De Baere, Siegrid ; Vanhaecke, Lynn ; De Backer, Patrick ; Croubels, Siska
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subjectAnimals–Metabolism ; Biological Availability–Metabolism ; Biotransformation–Metabolism ; Chickens–Pharmacokinetics ; Female–Pharmacokinetics ; Toxicokinetics–Pharmacokinetics ; Turkeys–Pharmacokinetics ; Zearalenone–Pharmacokinetics ; Zearalenone ; Biotransformation ; Broiler Chicken ; Laying Hen ; Poultry ; Toxicokinetics ; Turkey ; Zearalenone
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descriptionAfter oral (PO) and intravenous (IV) administration of zearalenone (ZEN) to broiler chickens, laying hens, and turkey poults, the mycotoxin was rapidly absorbed (T max = 0.32-0.97 h) in all three species; however, the absolute oral bioavailability was low (F% = 6.87-10.28%). Next, also a rapid elimination of the mycotoxin in all poultry species was observed (T 1/2el = 0.29-0.46 h). Both α- and β-zearalenone (ZEL) were formed equally after IV administration in all species studied, whereas an increased biotransformation to β-ZEL was demonstrated after PO administration, indicating presystemic biotransformation mainly in broiler chickens and laying hens. In comparison to the latter, turkey poults demonstrated a more extensive biotransformation of ZEN to α-ZEL after PO administration which could, in combination with the observed higher volume of distribution of ZEN, indicate a higher sensitivity of this species to the effects of ZEN in comparison to other poultry species. ; p. 5092-5098.
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