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I just ran a thousand analyses: benefits of multiple testing in understanding equivocal evidence on gene-environment interactions.

BACKGROUNDIn psychiatric genetics research, the volume of ambivalent findings on gene-environment interactions (G x E) is growing at an accelerating pace. In response to the surging suspicions of systematic distortion, we challenge the notion of chance capitalization as a possible contributor. Beyon... Full description

Journal Title: PloS one 2015, Vol.10(5), p.e0125383
Main Author: Heininga, Vera E
Other Authors: Oldehinkel, Albertine J , Veenstra, René , Nederhof, Esther
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0125383
Link: http://search.proquest.com/docview/1684435306/?pq-origsite=primo
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recordid: proquest1684435306
title: I just ran a thousand analyses: benefits of multiple testing in understanding equivocal evidence on gene-environment interactions.
format: Article
creator:
  • Heininga, Vera E
  • Oldehinkel, Albertine J
  • Veenstra, René
  • Nederhof, Esther
subjects:
  • Adolescent–Genetics
  • Adult–Genetics
  • Alleles–Genetics
  • Child Abuse–Genetics
  • Depression–Genetics
  • Female–Genetics
  • Gene-Environment Interaction–Genetics
  • Genetic Predisposition to Disease–Genetics
  • Genotype–Genetics
  • Humans–Genetics
  • Life Change Events–Genetics
  • Male–Genetics
  • Serotonin Plasma Membrane Transport Proteins–Genetics
  • Sex Factors–Genetics
  • Young Adult–Genetics
  • Slc6a4 Protein, Human
  • Serotonin Plasma Membrane Transport Proteins
ispartof: PloS one, 2015, Vol.10(5), p.e0125383
description: BACKGROUNDIn psychiatric genetics research, the volume of ambivalent findings on gene-environment interactions (G x E) is growing at an accelerating pace. In response to the surging suspicions of systematic distortion, we challenge the notion of chance capitalization as a possible contributor. Beyond...
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0125383
fulltext: fulltext
issn:
  • 19326203
  • 1932-6203
url: Link


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titleI just ran a thousand analyses: benefits of multiple testing in understanding equivocal evidence on gene-environment interactions.
creatorHeininga, Vera E ; Oldehinkel, Albertine J ; Veenstra, René ; Nederhof, Esther
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identifierE-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0125383
subjectAdolescent–Genetics ; Adult–Genetics ; Alleles–Genetics ; Child Abuse–Genetics ; Depression–Genetics ; Female–Genetics ; Gene-Environment Interaction–Genetics ; Genetic Predisposition to Disease–Genetics ; Genotype–Genetics ; Humans–Genetics ; Life Change Events–Genetics ; Male–Genetics ; Serotonin Plasma Membrane Transport Proteins–Genetics ; Sex Factors–Genetics ; Young Adult–Genetics ; Slc6a4 Protein, Human ; Serotonin Plasma Membrane Transport Proteins
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abstractBACKGROUNDIn psychiatric genetics research, the volume of ambivalent findings on gene-environment interactions (G x E) is growing at an accelerating pace. In response to the surging suspicions of systematic distortion, we challenge the notion of chance capitalization as a possible contributor. Beyond...
doi10.1371/journal.pone.0125383
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date2015-01-01