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Identification of Personalized Chemoresistance Genes in Subtypes of Basal-Like Breast Cancer Based on Functional Differences Using Pathway Analysis

Breast cancer is a highly heterogeneous disease that is clinically classified into several subtypes. Among these subtypes, basal-like breast cancer largely overlaps with triple-negative breast cancer (TNBC), and these two groups are generally studied together as a single entity. Differences in the m... Full description

Journal Title: PLoS One Jun 2015, Vol.10(6), p.e0131183
Main Author: Wu, Tong
Other Authors: Wang, Xudong , Li, Jing , Song, Xiuzhen , Wang, Ying , Wang, Yunfeng , Zhang, Lei , Li, Ziyao , Tian, Jiawei
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 19326203 ; DOI: 10.1371/journal.pone.0131183
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recordid: proquest1692287442
title: Identification of Personalized Chemoresistance Genes in Subtypes of Basal-Like Breast Cancer Based on Functional Differences Using Pathway Analysis
format: Article
creator:
  • Wu, Tong
  • Wang, Xudong
  • Li, Jing
  • Song, Xiuzhen
  • Wang, Ying
  • Wang, Yunfeng
  • Zhang, Lei
  • Li, Ziyao
  • Tian, Jiawei
subjects:
  • China
  • Pathways
  • Etiology
  • Identification Methods
  • Genes
  • Cancer
  • Breast Cancer
  • Test Procedures
  • Cancer Therapies
  • Drug Resistance
  • Lck Protein
  • Patients
  • Pharmacology
  • Peroxisome Proliferator-Activated Receptors
  • Hospitals
  • Breast Cancer
  • Ciita Protein
  • Kinases
  • Test Methods
  • Molecular Chains
ispartof: PLoS One, Jun 2015, Vol.10(6), p.e0131183
description: Breast cancer is a highly heterogeneous disease that is clinically classified into several subtypes. Among these subtypes, basal-like breast cancer largely overlaps with triple-negative breast cancer (TNBC), and these two groups are generally studied together as a single entity. Differences in the molecular makeup of breast cancers can result in different treatment strategies and prognoses for patients with different breast cancer subtypes. Compared with other subtypes, basal-like and other ER+ breast cancer subtypes exhibit marked differences in etiologic factors, clinical characteristics and therapeutic potential. Anthracycline drugs are typically used as the first-line clinical treatment for basal-like breast cancer subtypes. However, certain patients develop drug resistance following chemotherapy, which can lead to disease relapse and death. Even among patients with basal-like breast cancer, there can be significant molecular differences, and it is difficult to identify specific drug...
language: eng
source:
identifier: E-ISSN: 19326203 ; DOI: 10.1371/journal.pone.0131183
fulltext: fulltext_linktorsrc
issn:
  • 19326203
  • 1932-6203
url: Link


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titleIdentification of Personalized Chemoresistance Genes in Subtypes of Basal-Like Breast Cancer Based on Functional Differences Using Pathway Analysis
creatorWu, Tong ; Wang, Xudong ; Li, Jing ; Song, Xiuzhen ; Wang, Ying ; Wang, Yunfeng ; Zhang, Lei ; Li, Ziyao ; Tian, Jiawei
ispartofPLoS One, Jun 2015, Vol.10(6), p.e0131183
identifierE-ISSN: 19326203 ; DOI: 10.1371/journal.pone.0131183
subjectChina ; Pathways ; Etiology ; Identification Methods ; Genes ; Cancer ; Breast Cancer ; Test Procedures ; Cancer Therapies ; Drug Resistance ; Lck Protein ; Patients ; Pharmacology ; Peroxisome Proliferator-Activated Receptors ; Hospitals ; Breast Cancer ; Ciita Protein ; Kinases ; Test Methods ; Molecular Chains
descriptionBreast cancer is a highly heterogeneous disease that is clinically classified into several subtypes. Among these subtypes, basal-like breast cancer largely overlaps with triple-negative breast cancer (TNBC), and these two groups are generally studied together as a single entity. Differences in the molecular makeup of breast cancers can result in different treatment strategies and prognoses for patients with different breast cancer subtypes. Compared with other subtypes, basal-like and other ER+ breast cancer subtypes exhibit marked differences in etiologic factors, clinical characteristics and therapeutic potential. Anthracycline drugs are typically used as the first-line clinical treatment for basal-like breast cancer subtypes. However, certain patients develop drug resistance following chemotherapy, which can lead to disease relapse and death. Even among patients with basal-like breast cancer, there can be significant molecular differences, and it is difficult to identify specific drug...
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titleIdentification of Personalized Chemoresistance Genes in Subtypes of Basal-Like Breast Cancer Based on Functional Differences Using Pathway Analysis
descriptionBreast cancer is a highly heterogeneous disease that is clinically classified into several subtypes. Among these subtypes, basal-like breast cancer largely overlaps with triple-negative breast cancer (TNBC), and these two groups are generally studied together as a single entity. Differences in the molecular makeup of breast cancers can result in different treatment strategies and prognoses for patients with different breast cancer subtypes. Compared with other subtypes, basal-like and other ER+ breast cancer subtypes exhibit marked differences in etiologic factors, clinical characteristics and therapeutic potential. Anthracycline drugs are typically used as the first-line clinical treatment for basal-like breast cancer subtypes. However, certain patients develop drug resistance following chemotherapy, which can lead to disease relapse and death. Even among patients with basal-like breast cancer, there can be significant molecular differences, and it is difficult to identify specific drug...
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titleIdentification of Personalized Chemoresistance Genes in Subtypes of Basal-Like Breast Cancer Based on Functional Differences Using Pathway Analysis
authorWu, Tong ; Wang, Xudong ; Li, Jing ; Song, Xiuzhen ; Wang, Ying ; Wang, Yunfeng ; Zhang, Lei ; Li, Ziyao ; Tian, Jiawei
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abstractBreast cancer is a highly heterogeneous disease that is clinically classified into several subtypes. Among these subtypes, basal-like breast cancer largely overlaps with triple-negative breast cancer (TNBC), and these two groups are generally studied together as a single entity. Differences in the molecular makeup of breast cancers can result in different treatment strategies and prognoses for patients with different breast cancer subtypes. Compared with other subtypes, basal-like and other ER+ breast cancer subtypes exhibit marked differences in etiologic factors, clinical characteristics and therapeutic potential. Anthracycline drugs are typically used as the first-line clinical treatment for basal-like breast cancer subtypes. However, certain patients develop drug resistance following chemotherapy, which can lead to disease relapse and death. Even among patients with basal-like breast cancer, there can be significant molecular differences, and it is difficult to identify specific drug...
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