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A FDG-PET Study of Metabolic Networks in Apolipoprotein E ε4 Allele Carriers.

Recently, some studies have applied the graph theory in brain network analysis in Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI). However, relatively little research has specifically explored the properties of the metabolic network in apolipoprotein E (APOE) epsilon 4 allele carriers.... Full description

Journal Title: PloS one 2015, Vol.10(7), p.e0132300
Main Author: Yao, Zhijun
Other Authors: Hu, Bin , Zheng, Jiaxiang , Zheng, Weihao , Chen, Xuejiao , Gao, Xiang , Xie, Yuanwei , Fang, Lei , Yao, Zhijun
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0132300
Link: http://search.proquest.com/docview/1696190181/?pq-origsite=primo
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title: A FDG-PET Study of Metabolic Networks in Apolipoprotein E ε4 Allele Carriers.
format: Article
creator:
  • Yao, Zhijun
  • Hu, Bin
  • Zheng, Jiaxiang
  • Zheng, Weihao
  • Chen, Xuejiao
  • Gao, Xiang
  • Xie, Yuanwei
  • Fang, Lei
  • Yao, Zhijun
subjects:
  • Aged–Genetics
  • Aged, 80 and Over–Diagnostic Imaging
  • Alleles–Metabolism
  • Apolipoprotein E4–Metabolism
  • Brain–Metabolism
  • Brain Mapping–Metabolism
  • Cluster Analysis–Metabolism
  • Female–Metabolism
  • Fluorodeoxyglucose F18–Metabolism
  • Heterozygote–Metabolism
  • Humans–Metabolism
  • Male–Metabolism
  • Metabolic Networks and Pathways–Metabolism
  • Middle Aged–Metabolism
  • Positron-Emission Tomography–Metabolism
  • Apolipoprotein E4
  • Fluorodeoxyglucose F18
ispartof: PloS one, 2015, Vol.10(7), p.e0132300
description: Recently, some studies have applied the graph theory in brain network analysis in Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI). However, relatively little research has specifically explored the properties of the metabolic network in apolipoprotein E (APOE) epsilon 4 allele carriers. In our study, all the subjects, including ADs, MCIs and NCs (normal controls) were divided into 165 APOE epsilon 4 carriers and 165 APOE epsilon 4 noncarriers. To establish the metabolic network for all brain regions except the cerebellum, cerebral glucose metabolism data obtained from FDG-PET (18F-fluorodeoxyglu-cose positron emission tomography) were segmented into 90 areas with automated anatomical labeling (AAL) template. Then, the properties of the networks were computed to explore the between-group differences. Our results suggested that both APOE epsilon 4 carriers and noncarriers showed the small-world properties. Besides, compared with APOE epsilon 4 noncarriers, the carriers showed a lower clustering coefficient. In addition, significant changes in 6 hub brain regions were found in between-group nodal centrality. Namely, compared with APOE epsilon 4 noncarriers, significant decreases of the nodal centrality were found in left insula, right insula, right anterior cingulate, right paracingulate gyri, left cuneus, as well as significant increases in left paracentral lobule and left heschl gyrus in APOE epsilon 4 carriers. Increased local short distance interregional correlations and disrupted long distance interregional correlations were found, which may support the point that the APOE epsilon 4 carriers were more similar with AD or MCI in FDG uptake. In summary, the organization of metabolic network in APOE epsilon 4 carriers indicated a less optimal pattern and APOE epsilon 4 might be a risk factor for AD.
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0132300
fulltext: fulltext
issn:
  • 19326203
  • 1932-6203
url: Link


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titleA FDG-PET Study of Metabolic Networks in Apolipoprotein E ε4 Allele Carriers.
creatorYao, Zhijun ; Hu, Bin ; Zheng, Jiaxiang ; Zheng, Weihao ; Chen, Xuejiao ; Gao, Xiang ; Xie, Yuanwei ; Fang, Lei ; Yao, Zhijun
contributorWeiner, Michael W (correspondence author) ; Aisen, Paul (record owner) ; Weiner, Michael ; Aisen, Paul ; Petersen, Ronald ; Jack, Clifford R ; Jagust, William ; Trojanowki, John Q ; Toga, Arthur W ; Beckett, Laurel ; Green, Robert C ; Saykin, Andrew J ; Morris, John ; Shaw, Leslie M ; Khachaturian, Zaven ; Sorensen, Greg ; Carrillo, Maria ; Kuller, Lew ; Raichle, Marc ; Paul, Steven ; Davies, Peter ; Fillit, Howard ; Hefti, Franz ; Holtzman, Davie ; Mesulam, M Marcel ; Potter, William ; Snyder, Peter ; Schwartz, Adam ; Green, Robert C ; Montine, Tom ; Petersen, Ronald ; Aisen, Paul ; Thomas, Ronald G ; Donohue, Michael ; Walter, Sarah ; Gessert, Devon ; Sather, Tamie ; Jiminez, Gus ; Beckett, Laurel ; Harvey, Danielle ; Donohue, Michael ; Jack, Clifford R ; Bernstein, Matthew ; Fox, Nick ; Thompson, Paul ; Schuff, Norbert ; Decarli, Charles ; Borowski, Bret ; Gunter, Jeff ; Senjem, Matt ; Vemuri, Prashanthi ; Jones, David ; Kantarci, Kejal ; Ward, Chad ; Jagust, William ; Koeppe, Robert A ; Foster, Norm ; Reiman, Eric M ; Chen, Kewei ; Mathis, Chet ; Landau, Susan ; Morris, John C ; Cairns, Nigel J ; Householder, Erin ; Taylor-Reinwald, Lisa ; Shaw, Leslie M ; Trojanowki, John Q ; Lee, Virginia ; Korecka, Magdalena ; Figurski, Michal ; Toga, Arthur W ; Crawford, Karen ; Neu, Scott ; Saykin, Andrew J ; Foroud, Tatiana M ; Potkin, Steven ; Shen, Li ; Faber, Kelley ; Kim, Sungeun ; Nho, Kwangsik ; Weiner, Michael W ; Thal, Lean ; Khachaturian, Zaven ; Thal, Leon ; Buckholtz, Neil ; Weiner, Michael W ; Snyder, Peter J ; Potter, William ; Paul, Steven ; Albert, Marylyn ; Frank, Richard ; Khachaturian, Zaven ; Hsiao, John ; Kaye, Jeffrey ; Quinn, Joseph ; Lind, Betty ; Carter, Raina ; Dolen, Sara ; Schneider, Lon S ; Pawluczyk, Sonia ; Beccera, Mauricio ; Teodoro, Liberty ; Spann, Bryan M ; Brewer, James ; Vanderswag, Helen ; Fleisher, Adam ; Heidebrink, Judith L ; Lord, Joanne L ; Petersen, Ronald ; Mason, Sara S ; Albers, Colleen S ; Knopman, David ; Johnson, Kris ; Doody, Rachelle S ; Villanueva-Meyer, Javier ; Chowdhury, Munir ; Rountree, Susan ; Dang, Mimi ; Stern, Yaakov ; Honig, Lawrence S ; Bell, Karen L ; Ances, Beau ; Morris, John C ; Carroll, Maria ; Leon, Sue ; Householder, Erin ; Mintun, Mark A ; Schneider, Stacy ; Oliver, Angela ; Marson, Daniel ; Griffith, Randall ; Clark, David ; Geldmacher, David ; Brockington, John ; Roberson, Erik ; Grossman, Hillel ; Mitsis, Effie ; Detoledo-Morrell, Leyla ; Shah, Raj C ; Duara, Ranjan ; Varon, Daniel ; Greig, Maria T ; Roberts, Peggy ; Albert, Marilyn ; Onyike, Chiadi ; D'Agostino, Daniel ; Kielb, Stephanie ; Galvin, James E ; Pogorelec, Dana M ; Cerbone, Brittany ; Michel, Christina A ; Rusinek, Henry ; de Leon, Mony J ; Glodzik, Lidia ; De Santi, Susan ; Doraiswamy, P Murali ; Petrella, Jeffrey R ; Wong, Terence Z ; Arnold, Steven E ; Karlawish, Jason H ; Wolk, David ; Smith, Charles D ; Jicha, Greg ; Hardy, Peter ; Sinha, Partha ; Oates, Elizabeth ; Conrad, Gary ; Lopez, Oscar L ; Oakley, Maryann ; Simpson, Donna M ; Porsteinsson, Anton P ; Goldstein, Bonnie S ; Martin, Kim ; Makino, Kelly M ; Ismail, M Saleem ; Brand, Connie ; Mulnard, Ruth A ; Thai, Gaby ; Mc-Adams-Ortiz, Catherine ; Womack, Kyle ; Mathews, Dana ; Quiceno, Mary ; Diaz-Arrastia, Ramon ; King, Richard ; Weiner, Myron ; Martin-Cook, Kristen ; Devous, Michael ; Levey, Allan I ; Lah, James J ; Cellar, Janet S ; Burns, Jeffrey M ; Anderson, Heather S ; Swerdlow, Russell H ; Apostolova, Liana ; Tingus, Kathleen ; Woo, Ellen ; Silverman, Daniel H S ; Lu, Po H ; Bartzokis, George ; Graff-Radford, Neill R ; Parfitt, Francine ; Kendall, Tracy ; Johnson, Heather ; Farlow, Martin R ; Hake, Ann Marie ; Matthews, Brandy R ; Herring, Scott ; Hunt, Cynthia ; van Dyck, Christopher H ; Carson, Richard E ; Macavoy, Martha G ; Chertkow, Howard ; Bergman, Howard ; Hosein, Chris ; Black, Sandra ; Stefanovic, Bojana ; Caldwell, Curtis ; Hsiung, Ging-Yuek Robin ; Feldman, Howard ; Mudge, Benita ; Assaly, Michele ; Kertesz, Andrew ; Rogers, John ; Trost, Dick ; Bernick, Charles ; Munic, Donna ; Kerwin, Diana ; Mesulam, Marek-Marsel ; Lipowski, Kristine ; Wu, Chuang-Kuo ; Johnson, Nancy ; Sadowsky, Carl ; Martinez, Walter ; Villena, Teresa ; Turner, Raymond Scott ; Johnson, Kathleen ; Reynolds, Brigid ; Sperling, Reisa A ; Johnson, Keith A ; Marshall, Gad ; Frey, Meghan
ispartofPloS one, 2015, Vol.10(7), p.e0132300
identifierE-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0132300
subjectAged–Genetics ; Aged, 80 and Over–Diagnostic Imaging ; Alleles–Metabolism ; Apolipoprotein E4–Metabolism ; Brain–Metabolism ; Brain Mapping–Metabolism ; Cluster Analysis–Metabolism ; Female–Metabolism ; Fluorodeoxyglucose F18–Metabolism ; Heterozygote–Metabolism ; Humans–Metabolism ; Male–Metabolism ; Metabolic Networks and Pathways–Metabolism ; Middle Aged–Metabolism ; Positron-Emission Tomography–Metabolism ; Apolipoprotein E4 ; Fluorodeoxyglucose F18
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descriptionRecently, some studies have applied the graph theory in brain network analysis in Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI). However, relatively little research has specifically explored the properties of the metabolic network in apolipoprotein E (APOE) epsilon 4 allele carriers. In our study, all the subjects, including ADs, MCIs and NCs (normal controls) were divided into 165 APOE epsilon 4 carriers and 165 APOE epsilon 4 noncarriers. To establish the metabolic network for all brain regions except the cerebellum, cerebral glucose metabolism data obtained from FDG-PET (18F-fluorodeoxyglu-cose positron emission tomography) were segmented into 90 areas with automated anatomical labeling (AAL) template. Then, the properties of the networks were computed to explore the between-group differences. Our results suggested that both APOE epsilon 4 carriers and noncarriers showed the small-world properties. Besides, compared with APOE epsilon 4 noncarriers, the carriers showed a lower clustering coefficient. In addition, significant changes in 6 hub brain regions were found in between-group nodal centrality. Namely, compared with APOE epsilon 4 noncarriers, significant decreases of the nodal centrality were found in left insula, right insula, right anterior cingulate, right paracingulate gyri, left cuneus, as well as significant increases in left paracentral lobule and left heschl gyrus in APOE epsilon 4 carriers. Increased local short distance interregional correlations and disrupted long distance interregional correlations were found, which may support the point that the APOE epsilon 4 carriers were more similar with AD or MCI in FDG uptake. In summary, the organization of metabolic network in APOE epsilon 4 carriers indicated a less optimal pattern and APOE epsilon 4 might be a risk factor for AD.
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titleA FDG-PET Study of Metabolic Networks in Apolipoprotein E ε4 Allele Carriers.
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titleA FDG-PET Study of Metabolic Networks in Apolipoprotein E ε4 Allele Carriers.
authorYao, Zhijun ; Hu, Bin ; Zheng, Jiaxiang ; Zheng, Weihao ; Chen, Xuejiao ; Gao, Xiang ; Xie, Yuanwei ; Fang, Lei ; Yao, Zhijun
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atitleA FDG-PET Study of Metabolic Networks in Apolipoprotein E ε4 Allele Carriers.
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