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Associations between Verbal Learning Slope and Neuroimaging Markers across the Cognitive Aging Spectrum.

A symptom of mild cognitive impairment (MCI) and Alzheimer's disease (AD) is a flat learning profile. Learning slope calculation methods vary, and the optimal method for capturing neuroanatomical changes associated with MCI and early AD pathology is unclear. This study cross-sectionally compared fou... Full description

Journal Title: Journal of the International Neuropsychological Society : JINS July 2015, Vol.21(6), pp.455-467
Main Author: Gifford, Katherine A
Other Authors: Phillips, Jeffrey S , Samuels, Lauren R , Lane, Elizabeth M , Bell, Susan P , Liu, Dandan , Hohman, Timothy J , Romano, Raymond R , Fritzsche, Laura R , Lu, Zengqi , Jefferson, Angela L , Gifford, Katherine A
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1469-7661 ; DOI: 10.1017/S1355617715000430
Link: http://search.proquest.com/docview/1700335148/?pq-origsite=primo
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title: Associations between Verbal Learning Slope and Neuroimaging Markers across the Cognitive Aging Spectrum.
format: Article
creator:
  • Gifford, Katherine A
  • Phillips, Jeffrey S
  • Samuels, Lauren R
  • Lane, Elizabeth M
  • Bell, Susan P
  • Liu, Dandan
  • Hohman, Timothy J
  • Romano, Raymond R
  • Fritzsche, Laura R
  • Lu, Zengqi
  • Jefferson, Angela L
  • Gifford, Katherine A
subjects:
  • Alzheimer Disease–Pathology
  • Apolipoprotein E4–Physiopathology
  • Brain–Genetics
  • Cognitive Aging–Pathology
  • Cognitive Dysfunction–Pathology
  • Female–Physiopathology
  • Humans–Physiology
  • Longitudinal Studies–Physiology
  • Male–Physiology
  • Mental Recall–Physiology
  • Neuroimaging–Physiology
  • Neuropsychological Tests–Physiology
  • Statistics As Topic–Physiology
  • Verbal Learning–Physiology
  • Apolipoprotein E4
  • Alzheimer’s Disease
  • Hippocampus
  • Mild Cognitive Impairment
  • Prefrontal Cortex
ispartof: Journal of the International Neuropsychological Society : JINS, July 2015, Vol.21(6), pp.455-467
description: A symptom of mild cognitive impairment (MCI) and Alzheimer's disease (AD) is a flat learning profile. Learning slope calculation methods vary, and the optimal method for capturing neuroanatomical changes associated with MCI and early AD pathology is unclear. This study cross-sectionally compared four different learning slope measures from the Rey Auditory Verbal Learning Test (simple slope, regression-based slope, two-slope method, peak slope) to structural neuroimaging markers of early AD neurodegeneration (hippocampal volume, cortical thickness in parahippocampal gyrus, precuneus, and lateral prefrontal cortex) across the cognitive aging spectrum [normal control (NC); (n=198; age=76 plus or minus 5), MCI (n=370; age=75 plus or minus 7), and AD (n=171; age=76 plus or minus 7)] in ADNI. Within diagnostic group, general linear models related slope methods individually to neuroimaging variables, adjusting for age, sex, education, and APOE4 status. Among MCI, better learning performance on simple slope, regression-based slope, and late slope (Trial 2-5) from the two-slope method related to larger parahippocampal thickness (all p-values
language: eng
source:
identifier: E-ISSN: 1469-7661 ; DOI: 10.1017/S1355617715000430
fulltext: fulltext
issn:
  • 14697661
  • 1469-7661
url: Link


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titleAssociations between Verbal Learning Slope and Neuroimaging Markers across the Cognitive Aging Spectrum.
creatorGifford, Katherine A ; Phillips, Jeffrey S ; Samuels, Lauren R ; Lane, Elizabeth M ; Bell, Susan P ; Liu, Dandan ; Hohman, Timothy J ; Romano, Raymond R ; Fritzsche, Laura R ; Lu, Zengqi ; Jefferson, Angela L ; Gifford, Katherine A
contributorWeiner, Michael W (correspondence author) ; Aisen, Paul (record owner) ; Weiner, Michael ; Aisen, Paul ; Petersen, Ronald ; Jack, Clifford R ; Jagust, William ; Trojanowki, John Q ; Toga, Arthur W ; Beckett, Laurel ; Green, Robert C ; Saykin, Andrew J ; Morris, John ; Shaw, Leslie M ; Khachaturian, Zaven ; Sorensen, Greg ; Carrillo, Maria ; Kuller, Lew ; Raichle, Marc ; Paul
ispartofJournal of the International Neuropsychological Society : JINS, July 2015, Vol.21(6), pp.455-467
identifierE-ISSN: 1469-7661 ; DOI: 10.1017/S1355617715000430
subjectAlzheimer Disease–Pathology ; Apolipoprotein E4–Physiopathology ; Brain–Genetics ; Cognitive Aging–Pathology ; Cognitive Dysfunction–Pathology ; Female–Physiopathology ; Humans–Physiology ; Longitudinal Studies–Physiology ; Male–Physiology ; Mental Recall–Physiology ; Neuroimaging–Physiology ; Neuropsychological Tests–Physiology ; Statistics As Topic–Physiology ; Verbal Learning–Physiology ; Apolipoprotein E4 ; Alzheimer’s Disease ; Hippocampus ; Mild Cognitive Impairment ; Prefrontal Cortex
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descriptionA symptom of mild cognitive impairment (MCI) and Alzheimer's disease (AD) is a flat learning profile. Learning slope calculation methods vary, and the optimal method for capturing neuroanatomical changes associated with MCI and early AD pathology is unclear. This study cross-sectionally compared four different learning slope measures from the Rey Auditory Verbal Learning Test (simple slope, regression-based slope, two-slope method, peak slope) to structural neuroimaging markers of early AD neurodegeneration (hippocampal volume, cortical thickness in parahippocampal gyrus, precuneus, and lateral prefrontal cortex) across the cognitive aging spectrum [normal control (NC); (n=198; age=76 plus or minus 5), MCI (n=370; age=75 plus or minus 7), and AD (n=171; age=76 plus or minus 7)] in ADNI. Within diagnostic group, general linear models related slope methods individually to neuroimaging variables, adjusting for age, sex, education, and APOE4 status. Among MCI, better learning performance on simple slope, regression-based slope, and late slope (Trial 2-5) from the two-slope method related to larger parahippocampal thickness (all p-values<.01) and hippocampal volume (p<.01). Better regression-based slope (p<.01) and late slope (p<.01) were related to larger ventrolateral prefrontal cortex in MCI. No significant associations emerged between any slope and neuroimaging variables for NC (p-values greater than or equal to .05) or AD (p-values greater than or equal to .02). Better learning performances related to larger medial temporal lobe (i.e., hippocampal volume, parahippocampal gyrus thickness) and ventrolateral prefrontal cortex in MCI only. Regression-based and late slope were most highly correlated with neuroimaging markers and explained more variance above and beyond other common memory indices, such as total learning. Simple slope may offer an acceptable alternative given its ease of calculation. (JINS, 2015, 21, 455-467)
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9Lu, Zengqi
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12Shaw, Leslie M
13Khachaturian, Zaven
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15Carrillo, Maria
16Kuller, Lew
17Raichle, Marc
18Paul, Steven
19Davies, Peter
20Fillit, Howard
21Hefti, Franz
22Holtzman, Davie
23Mesulam, M Marcel
24Potter, William
25Snyder, Peter
26Schwartz, Adam
27Montine, Tom
28Thomas, Ronald G
29Donohue, Michael
30Walter, Sarah
31Gessert, Devon
32Sather, Tamie
33Jiminez, Gus
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36Sim, Iris
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38Bernstein, Matthew
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56Morris, John C
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99Villanueva-Meyer, Javier
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titleAssociations between Verbal Learning Slope and Neuroimaging Markers across the Cognitive Aging Spectrum.
authorGifford, Katherine A ; Phillips, Jeffrey S ; Samuels, Lauren R ; Lane, Elizabeth M ; Bell, Susan P ; Liu, Dandan ; Hohman, Timothy J ; Romano, Raymond R ; Fritzsche, Laura R ; Lu, Zengqi ; Jefferson, Angela L ; Gifford, Katherine A
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2Brain–Genetics
3Cognitive Aging–Pathology
4Cognitive Dysfunction–Pathology
5Female–Physiopathology
6Humans–Physiology
7Longitudinal Studies–Physiology
8Male–Physiology
9Mental Recall–Physiology
10Neuroimaging–Physiology
11Neuropsychological Tests–Physiology
12Statistics As Topic–Physiology
13Verbal Learning–Physiology
14Apolipoprotein E4
15Alzheimer’s Disease
16Hippocampus
17Mild Cognitive Impairment
18Prefrontal Cortex
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8Fritzsche, Laura R
9Lu, Zengqi
10Jefferson, Angela L
11Weiner, Michael W
12Aisen, Paul
13Weiner, Michael
14Petersen, Ronald
15Jack, Clifford R
16Jagust, William
17Trojanowki, John Q
18Toga, Arthur W
19Beckett, Laurel
20Green, Robert C
21Saykin, Andrew J
22Morris, John
23Shaw, Leslie M
24Khachaturian, Zaven
25Sorensen, Greg
26Carrillo, Maria
27Kuller, Lew
28Raichle, Marc
29Paul, Steven
30Davies, Peter
31Fillit, Howard
32Hefti, Franz
33Holtzman, Davie
34Mesulam, M Marcel
35Potter, William
36Snyder, Peter
37Schwartz, Adam
38Montine, Tom
39Thomas, Ronald G
40Donohue, Michael
41Walter, Sarah
42Gessert, Devon
43Sather, Tamie
44Jiminez, Gus
45Balasubramanian, Archana B
46Mason, Jennifer
47Sim, Iris
48Harvey, Danielle
49Bernstein, Matthew
50Fox, Nick
51Thompson, Paul
52Schuff, Norbert
53Decarli, Charles
54Borowski, Bret
55Gunter, Jeff
56Senjem, Matt
57Vemuri, Prashanthi
58Jones, David
59Kantarci, Kejal
60Ward, Chad
61Koeppe, Robert A
62Foster, Norm
63Reiman, Eric M
64Chen, Kewei
65Mathis, Chet
66Landau, Susan
67Morris, John C
68Cairns, Nigel J
69Householder, Erin
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88Hsiao, John
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90Quinn, Joseph
91Silbert, Lisa
92Lind, Betty
93Carter, Raina
94Dolen, Sara
95Schneider, Lon S
96Pawluczyk, Sonia
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9Green, Robert C
10Saykin, Andrew J
11Morris, John
12Shaw, Leslie M
13Khachaturian, Zaven
14Sorensen, Greg
15Carrillo, Maria
16Kuller, Lew
17Raichle, Marc
18Paul, Steven
19Davies, Peter
20Fillit, Howard
21Hefti, Franz
22Holtzman, Davie
23Mesulam, M Marcel
24Potter, William
25Snyder, Peter
26Schwartz, Adam
27Montine, Tom
28Thomas, Ronald G
29Donohue, Michael
30Walter, Sarah
31Gessert, Devon
32Sather, Tamie
33Jiminez, Gus
34Balasubramanian, Archana B
35Mason, Jennifer
36Sim, Iris
37Harvey, Danielle
38Bernstein, Matthew
39Fox, Nick
40Thompson, Paul
41Schuff, Norbert
42DeCArli, Charles
43Borowski, Bret
44Gunter, Jeff
45Senjem, Matt
46Vemuri, Prashanthi
47Jones, David
48Kantarci, Kejal
49Ward, Chad
50Koeppe, Robert A
51Foster, Norm
52Reiman, Eric M
53Chen, Kewei
54Mathis, Chet
55Landau, Susan
56Morris, John C
57Cairns, Nigel J
58Householder, Erin
59Taylor-Reinwald, Lisa
60Lee, Virginia
61Korecka, Magdalena
62Figurski, Michal
63Crawford, Karen
64Neu, Scott
65Foroud, Tatiana M
66Potkin, Steven
67Shen, Li
68Faber, Kelley
69Kim, Sungeun
70Nho, Kwangsik
71Thal, Lean
72Thal, Leon
73Buckholtz, Neil
74Snyder, Peter J
75Albert, Marylyn
76Frank, Richard
77Hsiao, John
78Kaye, Jeffrey
79Quinn, Joseph
80Silbert, Lisa
81Lind, Betty
82Carter, Raina
83Dolen, Sara
84Schneider, Lon S
85Pawluczyk, Sonia
86Beccera, Mauricio
87Teodoro, Liberty
88Spann, Bryan M
89Brewer, James
90Vanderswag, Helen
91Fleisher, Adam
92Heidebrink, Judith L
93Lord, Joanne L
94Mason, Sara S
95Albers, Colleen S
96Knopman, David
97Johnson, Kris
98Doody, Rachelle S
99Villanueva-Meyer, Javier
100...
atitleAssociations between Verbal Learning Slope and Neuroimaging Markers across the Cognitive Aging Spectrum.
jtitleJournal of the International Neuropsychological Society : JINS
risdate20150701
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