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Detection of microRNA SNPs with ultrahigh specificity by using reduced graphene oxide-assisted rolling circle amplification

Here we report a reduced graphene oxide-assisted rolling circle amplification for the detection of miRNA SNPs. The difference of the signal of a miRNA SNP reaches 100 fold, a value over 10 times larger than some current methodologies, which allows the discrimination of a SNP even with the naked eye.

Journal Title: Chemical Communications: Chem Comm Jun 2015, Vol.51(49), pp.10002-10005
Main Author: Zhu, Xiaoli
Other Authors: Shen, Yalan , Cao, Jiepei , Yin, Li , Ban, Fangfang , Shu, Yongqian , Li, Genxi
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1359-7345 ; E-ISSN: 1364-548X ; DOI: 10.1039/c5cc02039e
Link: http://search.proquest.com/docview/1701040998/?pq-origsite=primo
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recordid: proquest1701040998
title: Detection of microRNA SNPs with ultrahigh specificity by using reduced graphene oxide-assisted rolling circle amplification
format: Article
creator:
  • Zhu, Xiaoli
  • Shen, Yalan
  • Cao, Jiepei
  • Yin, Li
  • Ban, Fangfang
  • Shu, Yongqian
  • Li, Genxi
subjects:
  • Amplification
  • Graphene
  • Ribonucleic Acids
  • Discrimination
  • Miscellaneous Sciences (So)
  • Chemical and Electrochemical Properties (MD)
  • Chemical and Electrochemical Properties (Ep)
  • Chemical and Electrochemical Properties (Ed)
  • Chemical and Electrochemical Properties (EC)
ispartof: Chemical Communications: Chem Comm, Jun 2015, Vol.51(49), pp.10002-10005
description: Here we report a reduced graphene oxide-assisted rolling circle amplification for the detection of miRNA SNPs. The difference of the signal of a miRNA SNP reaches 100 fold, a value over 10 times larger than some current methodologies, which allows the discrimination of a SNP even with the naked eye.
language: eng
source:
identifier: ISSN: 1359-7345 ; E-ISSN: 1364-548X ; DOI: 10.1039/c5cc02039e
fulltext: fulltext
issn:
  • 13597345
  • 1359-7345
  • 1364548X
  • 1364-548X
url: Link


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descriptionHere we report a reduced graphene oxide-assisted rolling circle amplification for the detection of miRNA SNPs. The difference of the signal of a miRNA SNP reaches 100 fold, a value over 10 times larger than some current methodologies, which allows the discrimination of a SNP even with the naked eye.
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abstractHere we report a reduced graphene oxide-assisted rolling circle amplification for the detection of miRNA SNPs. The difference of the signal of a miRNA SNP reaches 100 fold, a value over 10 times larger than some current methodologies, which allows the discrimination of a SNP even with the naked eye.
doi10.1039/c5cc02039e
urlhttp://search.proquest.com/docview/1701040998/
date2015-06-01