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Unchanged gastric emptying and visceral perception in early Parkinson's disease after a high caloric test meal.

Byline: L. Epprecht (1), S. R. Schreglmann (2,6), O. Goetze (3,5), D. Woitalla (4), C. R. Baumann (2), D. Waldvogel (2) Keywords: Gastric emptying; Parkinson's disease; High caloric test meal; Appetite sensation; Dopaminergic treatment Abstract: Delayed gastric emptying (GE) is a frequent non-motor... Full description

Journal Title: Journal of neurology August 2015, Vol.262(8), pp.1946-1953
Main Author: Epprecht, L
Other Authors: Schreglmann, S R , Goetze, O , Woitalla, D , Baumann, C R , Waldvogel, D
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1432-1459 ; DOI: 10.1007/s00415-015-7799-z
Link: http://search.proquest.com/docview/1705476690/?pq-origsite=primo
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title: Unchanged gastric emptying and visceral perception in early Parkinson's disease after a high caloric test meal.
format: Article
creator:
  • Epprecht, L
  • Schreglmann, S R
  • Goetze, O
  • Woitalla, D
  • Baumann, C R
  • Waldvogel, D
subjects:
  • Adult–Drug Effects
  • Aged–Administration & Dosage
  • Appetite–Adverse Effects
  • Benserazide–Administration & Dosage
  • Breath Tests–Adverse Effects
  • Caprylates–Drug Effects
  • Dopamine Agents–Administration & Dosage
  • Drug Combinations–Adverse Effects
  • Gastric Emptying–Drug Therapy
  • Humans–Drug Therapy
  • Levodopa–Drug Therapy
  • Male–Drug Therapy
  • Middle Aged–Drug Therapy
  • Parkinson Disease–Drug Therapy
  • Prospective Studies–Drug Therapy
  • Caprylates
  • Dopamine Agents
  • Drug Combinations
  • Benserazide, Levodopa Drug Combination
  • Levodopa
  • Benserazide
  • Octanoic Acid
ispartof: Journal of neurology, August 2015, Vol.262(8), pp.1946-1953
description: Byline: L. Epprecht (1), S. R. Schreglmann (2,6), O. Goetze (3,5), D. Woitalla (4), C. R. Baumann (2), D. Waldvogel (2) Keywords: Gastric emptying; Parkinson's disease; High caloric test meal; Appetite sensation; Dopaminergic treatment Abstract: Delayed gastric emptying (GE) is a frequent non-motor feature in ParkinsonA[acute accent]s disease (PD). This prospective study (clinicaltrials.gov Identifier NCT01518751) investigated GE and visceral perception in early motor phase PD patients in comparison to age-matched and younger controls. In addition, the effect of Levodopa on GE was assessed in healthy aged controls. 16 PD patients (Hoehn & Yahr 2), 11 sex-/age-matched Ctrl1 and 10 young, male Ctrl2 subjects were subjected to a high caloric (428 kcal) 13.sup.C-Sodium Octanoate breath test strictly OFF dopaminergic medication. Visceral appetite sensation was monitored using visual analogue scales (VAS). GE was similarly studied in 7 controls ON/OFF oral Levodopa. GE was not altered in PD patients compared to age-/sex-matched and younger controls (p = 0.76). Subjective appetite perception was not altered in the PD group in comparison to Ctrl1, but was significantly higher in Ctrl2 subjects (p = 0.02). 100 mg oral Levodopa/25 mg Benserazide significantly slowed GE by 18 % among healthy controls (p = 0.04). In early motor stage PD OFF dopaminergic medication, there was no GE slowing after a high caloric test meal. Levodopa, however, caused a robust GE slowing in healthy aged individuals. Our data indicate that clinically relevant GE slowing in early PD is related to the iatrogenic effect of dopamine treatment. Subjective appetite perception is not affected in this disease stage. This data add to the understanding of gastrointestinal symptoms in early motor stage PD and highlight the influence of dopaminergic medication. Author Affiliation: (1) Department of Neurosurgery, Kantonsspital St.Gallen, St.Gallen, Switzerland (2) Department of Neurology, University Hospital Zurich, Zurich, Switzerland (3) Division of Gastroenterology, University Hospital Zurich, Zurich, Switzerland (4) Department of Neurology, St. Josef-Hospital, Ruhr-University of Bochum, Bochum, Germany (5) Division of Hepatology, Department of Medicine II, University Hospital Wuerzburg, Wurzburg, Germany (6) Department of Neurology, Kantonsspital St.Gallen, Rorschacher Strasse 95, 9007, St.Gallen, Switzerland Article History: Registration Date: 26/05/2015 Received Date: 30/03/2015 Accepted Date: 25/0
language: eng
source:
identifier: E-ISSN: 1432-1459 ; DOI: 10.1007/s00415-015-7799-z
fulltext: fulltext
issn:
  • 14321459
  • 1432-1459
url: Link


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titleUnchanged gastric emptying and visceral perception in early Parkinson's disease after a high caloric test meal.
creatorEpprecht, L ; Schreglmann, S R ; Goetze, O ; Woitalla, D ; Baumann, C R ; Waldvogel, D
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ispartofJournal of neurology, August 2015, Vol.262(8), pp.1946-1953
identifierE-ISSN: 1432-1459 ; DOI: 10.1007/s00415-015-7799-z
subjectAdult–Drug Effects ; Aged–Administration & Dosage ; Appetite–Adverse Effects ; Benserazide–Administration & Dosage ; Breath Tests–Adverse Effects ; Caprylates–Drug Effects ; Dopamine Agents–Administration & Dosage ; Drug Combinations–Adverse Effects ; Gastric Emptying–Drug Therapy ; Humans–Drug Therapy ; Levodopa–Drug Therapy ; Male–Drug Therapy ; Middle Aged–Drug Therapy ; Parkinson Disease–Drug Therapy ; Prospective Studies–Drug Therapy ; Caprylates ; Dopamine Agents ; Drug Combinations ; Benserazide, Levodopa Drug Combination ; Levodopa ; Benserazide ; Octanoic Acid
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descriptionByline: L. Epprecht (1), S. R. Schreglmann (2,6), O. Goetze (3,5), D. Woitalla (4), C. R. Baumann (2), D. Waldvogel (2) Keywords: Gastric emptying; Parkinson's disease; High caloric test meal; Appetite sensation; Dopaminergic treatment Abstract: Delayed gastric emptying (GE) is a frequent non-motor feature in ParkinsonA[acute accent]s disease (PD). This prospective study (clinicaltrials.gov Identifier NCT01518751) investigated GE and visceral perception in early motor phase PD patients in comparison to age-matched and younger controls. In addition, the effect of Levodopa on GE was assessed in healthy aged controls. 16 PD patients (Hoehn & Yahr 2), 11 sex-/age-matched Ctrl1 and 10 young, male Ctrl2 subjects were subjected to a high caloric (428 kcal) 13.sup.C-Sodium Octanoate breath test strictly OFF dopaminergic medication. Visceral appetite sensation was monitored using visual analogue scales (VAS). GE was similarly studied in 7 controls ON/OFF oral Levodopa. GE was not altered in PD patients compared to age-/sex-matched and younger controls (p = 0.76). Subjective appetite perception was not altered in the PD group in comparison to Ctrl1, but was significantly higher in Ctrl2 subjects (p = 0.02). 100 mg oral Levodopa/25 mg Benserazide significantly slowed GE by 18 % among healthy controls (p = 0.04). In early motor stage PD OFF dopaminergic medication, there was no GE slowing after a high caloric test meal. Levodopa, however, caused a robust GE slowing in healthy aged individuals. Our data indicate that clinically relevant GE slowing in early PD is related to the iatrogenic effect of dopamine treatment. Subjective appetite perception is not affected in this disease stage. This data add to the understanding of gastrointestinal symptoms in early motor stage PD and highlight the influence of dopaminergic medication. Author Affiliation: (1) Department of Neurosurgery, Kantonsspital St.Gallen, St.Gallen, Switzerland (2) Department of Neurology, University Hospital Zurich, Zurich, Switzerland (3) Division of Gastroenterology, University Hospital Zurich, Zurich, Switzerland (4) Department of Neurology, St. Josef-Hospital, Ruhr-University of Bochum, Bochum, Germany (5) Division of Hepatology, Department of Medicine II, University Hospital Wuerzburg, Wurzburg, Germany (6) Department of Neurology, Kantonsspital St.Gallen, Rorschacher Strasse 95, 9007, St.Gallen, Switzerland Article History: Registration Date: 26/05/2015 Received Date: 30/03/2015 Accepted Date: 25/05/2015 Online Date: 06/06/2015 Article note: L. Epprecht, S. R. Schreglmann contributed equally.
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titleUnchanged gastric emptying and visceral perception in early Parkinson's disease after a high caloric test meal.
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