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Encapsulated Brucella ovis Lacking a Putative ATP-Binding Cassette Transporter (ΔabcBA) Protects against Wild Type Brucella ovis in Rams.

This study aimed to evaluate protection induced by the vaccine candidate B. ovis [DELTA]abcBA against experimental challenge with wild type B. ovis in rams. Rams were subcutaneously immunized with B. ovis [DELTA]abcBA encapsulated with sterile alginate or with the non encapsulated vaccine strain. Se... Full description

Journal Title: PloS one 2015, Vol.10(8), p.e0136865
Main Author: Silva, Ana Patrícia C
Other Authors: Macêdo, Auricélio A , Costa, Luciana F , Rocha, Cláudia E , Garcia, Luize N N , Farias, Jade R D , Gomes, Priscilla P R , Teixeira, Gustavo C , Fonseca, Kessler W J , Maia, Andréa R F , Neves, Gabriela G , Romão, Everton L , Silva, Teane M A , Mol, Juliana P S , Oliveira, Renata M , Araújo, Márcio S S , Nascimento, Ernane F , Martins-Filho, Olindo A , Brandão, Humberto M , Paixão, Tatiane A , Santos, Renato L
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0136865
Link: http://search.proquest.com/docview/1708900797/?pq-origsite=primo
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title: Encapsulated Brucella ovis Lacking a Putative ATP-Binding Cassette Transporter (ΔabcBA) Protects against Wild Type Brucella ovis in Rams.
format: Article
creator:
  • Silva, Ana Patrícia C
  • Macêdo, Auricélio A
  • Costa, Luciana F
  • Rocha, Cláudia E
  • Garcia, Luize N N
  • Farias, Jade R D
  • Gomes, Priscilla P R
  • Teixeira, Gustavo C
  • Fonseca, Kessler W J
  • Maia, Andréa R F
  • Neves, Gabriela G
  • Romão, Everton L
  • Silva, Teane M A
  • Mol, Juliana P S
  • Oliveira, Renata M
  • Araújo, Márcio S S
  • Nascimento, Ernane F
  • Martins-Filho, Olindo A
  • Brandão, Humberto M
  • Paixão, Tatiane A
  • Santos, Renato L
subjects:
  • ATP-Binding Cassette Transporters–Deficiency
  • Alginates–Chemistry
  • Animals–Genetics
  • Bacterial Proteins–Microbiology
  • Blood–Administration & Dosage
  • Brucella Vaccine–Genetics
  • Brucella Ovis–Pharmacology
  • Brucellosis–Genetics
  • Capsules–Immunology
  • Glucuronic Acid–Metabolism
  • Hexuronic Acids–Immunology
  • Injections, Subcutaneous–Microbiology
  • Male–Prevention & Control
  • Semen–Veterinary
  • Sheep–Administration & Dosage
  • Sheep Diseases–Pharmacology
  • Sheep, Domestic–Chemistry
  • Urine–Chemistry
  • Urine–Microbiology
  • Urine–Immunology
  • Urine–Microbiology
  • Urine–Prevention & Control
  • Urine–Microbiology
  • ATP-Binding Cassette Transporters
  • Alginates
  • Bacterial Proteins
  • Brucella Vaccine
  • Capsules
  • Hexuronic Acids
  • Glucuronic Acid
ispartof: PloS one, 2015, Vol.10(8), p.e0136865
description: This study aimed to evaluate protection induced by the vaccine candidate B. ovis [DELTA]abcBA against experimental challenge with wild type B. ovis in rams. Rams were subcutaneously immunized with B. ovis [DELTA]abcBA encapsulated with sterile alginate or with the non encapsulated vaccine strain. Serum, urine, and semen samples were collected during two months after immunization. The rams were then challenged with wild type B. ovis (ATCC25840), and the results were compared to non immunized and experimentally challenged rams. Immunization, particularly with encapsulated B. ovis [DELTA]abcBA, prevented infection, secretion of wild type B. ovis in the semen and urine, shedding of neutrophils in the semen, and the development of clinical changes, gross and microscopic lesions induced by the wild type B. ovis reference strain. Collectively, our data indicates that the B. ovis [DELTA]abcBA strain is an exceptionally good vaccine strain for preventing brucellosis caused by B. ovis infection in rams.
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0136865
fulltext: fulltext
issn:
  • 19326203
  • 1932-6203
url: Link


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titleEncapsulated Brucella ovis Lacking a Putative ATP-Binding Cassette Transporter (ΔabcBA) Protects against Wild Type Brucella ovis in Rams.
creatorSilva, Ana Patrícia C ; Macêdo, Auricélio A ; Costa, Luciana F ; Rocha, Cláudia E ; Garcia, Luize N N ; Farias, Jade R D ; Gomes, Priscilla P R ; Teixeira, Gustavo C ; Fonseca, Kessler W J ; Maia, Andréa R F ; Neves, Gabriela G ; Romão, Everton L ; Silva, Teane M A ; Mol, Juliana P S ; Oliveira, Renata M ; Araújo, Márcio S S ; Nascimento, Ernane F ; Martins-Filho, Olindo A ; Brandão, Humberto M ; Paixão, Tatiane A ; Santos, Renato L
contributorSilva, Ana Patrícia C (correspondence author) ; Silva, Ana Patrícia C (record owner)
ispartofPloS one, 2015, Vol.10(8), p.e0136865
identifierE-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0136865
subjectATP-Binding Cassette Transporters–Deficiency ; Alginates–Chemistry ; Animals–Genetics ; Bacterial Proteins–Microbiology ; Blood–Administration & Dosage ; Brucella Vaccine–Genetics ; Brucella Ovis–Pharmacology ; Brucellosis–Genetics ; Capsules–Immunology ; Glucuronic Acid–Metabolism ; Hexuronic Acids–Immunology ; Injections, Subcutaneous–Microbiology ; Male–Prevention & Control ; Semen–Veterinary ; Sheep–Administration & Dosage ; Sheep Diseases–Pharmacology ; Sheep, Domestic–Chemistry ; Urine–Chemistry ; Urine–Microbiology ; Urine–Immunology ; Urine–Microbiology ; Urine–Prevention & Control ; Urine–Microbiology ; ATP-Binding Cassette Transporters ; Alginates ; Bacterial Proteins ; Brucella Vaccine ; Capsules ; Hexuronic Acids ; Glucuronic Acid
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descriptionThis study aimed to evaluate protection induced by the vaccine candidate B. ovis [DELTA]abcBA against experimental challenge with wild type B. ovis in rams. Rams were subcutaneously immunized with B. ovis [DELTA]abcBA encapsulated with sterile alginate or with the non encapsulated vaccine strain. Serum, urine, and semen samples were collected during two months after immunization. The rams were then challenged with wild type B. ovis (ATCC25840), and the results were compared to non immunized and experimentally challenged rams. Immunization, particularly with encapsulated B. ovis [DELTA]abcBA, prevented infection, secretion of wild type B. ovis in the semen and urine, shedding of neutrophils in the semen, and the development of clinical changes, gross and microscopic lesions induced by the wild type B. ovis reference strain. Collectively, our data indicates that the B. ovis [DELTA]abcBA strain is an exceptionally good vaccine strain for preventing brucellosis caused by B. ovis infection in rams.
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17Martins-Filho, Olindo A
18Brandão, Humberto M
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titleEncapsulated Brucella ovis Lacking a Putative ATP-Binding Cassette Transporter (ΔabcBA) Protects against Wild Type Brucella ovis in Rams.
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titleEncapsulated Brucella ovis Lacking a Putative ATP-Binding Cassette Transporter (ΔabcBA) Protects against Wild Type Brucella ovis in Rams.
authorSilva, Ana Patrícia C ; Macêdo, Auricélio A ; Costa, Luciana F ; Rocha, Cláudia E ; Garcia, Luize N N ; Farias, Jade R D ; Gomes, Priscilla P R ; Teixeira, Gustavo C ; Fonseca, Kessler W J ; Maia, Andréa R F ; Neves, Gabriela G ; Romão, Everton L ; Silva, Teane M A ; Mol, Juliana P S ; Oliveira, Renata...
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atitleEncapsulated Brucella ovis Lacking a Putative ATP-Binding Cassette Transporter (ΔabcBA) Protects against Wild Type Brucella ovis in Rams.
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