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Effect of Sodium Selenite on Pathological Changes and Renal Functions in Broilers Fed a Diet Containing Aflatoxin B₁.

To evaluate the renal toxicity of dietary aflatoxin B sub( 1) (AFB sub( 1)) and ameliorating effects of added dietary sodium selenite in broiler, renal histopathological changes, ultrastructural changes, and renal function parameters were monitored at 7, 14, and 21 days of age. Two hundred one-day-o... Full description

Journal Title: International journal of environmental research and public health September 9, 2015, Vol.12(9), pp.11196-11208
Main Author: Liang, Na
Other Authors: Wang, Fengyuan , Peng, Xi , Fang, Jing , Cui, Hengmin , Chen, Zhengli , Lai, Weimin , Zhou, Yi , Geng, Yi
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1660-4601 ; DOI: 10.3390/ijerph120911196
Link: http://search.proquest.com/docview/1712775718/?pq-origsite=primo
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title: Effect of Sodium Selenite on Pathological Changes and Renal Functions in Broilers Fed a Diet Containing Aflatoxin B₁.
format: Article
creator:
  • Liang, Na
  • Wang, Fengyuan
  • Peng, Xi
  • Fang, Jing
  • Cui, Hengmin
  • Chen, Zhengli
  • Lai, Weimin
  • Zhou, Yi
  • Geng, Yi
subjects:
  • Aflatoxin B1–Toxicity
  • Animals–Blood
  • Body Weight–Drug Effects
  • Chickens–Ultrastructure
  • Creatinine–Blood
  • Dietary Supplements–Pathology
  • Kidney–Prevention & Control
  • Kidney Diseases–Toxicity
  • Male–Pharmacology
  • Poisons–Metabolism
  • Sodium Selenite–Pharmacology
  • Sodium-Potassium-Exchanging Atpase–Blood
  • Trace Elements–Blood
  • Uric Acid–Blood
  • Poisons
  • Trace Elements
  • Uric Acid
  • Aflatoxin B1
  • Creatinine
  • Sodium-Potassium-Exchanging Atpase
  • Sodium Selenite
  • Aflatoxin B1
  • Broiler
  • Pathological Observation
  • Renal Function
  • Sodium Selenite
  • Ultrastructural Observation
ispartof: International journal of environmental research and public health, September 9, 2015, Vol.12(9), pp.11196-11208
description: To evaluate the renal toxicity of dietary aflatoxin B sub( 1) (AFB sub( 1)) and ameliorating effects of added dietary sodium selenite in broiler, renal histopathological changes, ultrastructural changes, and renal function parameters were monitored at 7, 14, and 21 days of age. Two hundred one-day-old healthy male Avian broilers were divided into four groups, namely control group, AFB sub( 1) group (0.3 mg/kg AFB sub( 1)), +Se group (0.4 mg/kg Se), and AFB sub( 1)+Se group (0.3 mg/kg AFB sub( 1)+0.4 mg/kg Se). Compared with that of the control group, the relative weight of kidney was increased in the AFB sub( 1) group. There were no significant differences between the AFB sub( 1)+Se group and the control group. By histopathological observation, the renal epithelia were swelling and necrosis at 7 and 21 days of age. Ultrastructurally, the lipid droplets and expanded endoplasmic reticulum appeared in the plasma of epithelia cells in the AFB sub( 1) group. Enlarged mitochondria with degenerated cristae were observed in the +Se group. Compared with the control group, the contents of serum creatinine and serum uric acid in the AFB sub( 1) group were increased, while the activity of renal Na+-K+ ATPase was decreased. When 0.4 mg/kg selenium was added into the diet containing 0.3 mg/kg AFB sub( 1), there were no obvious histological changes in the AFB sub( 1)+Se group, and the contents of the serum creatinine and serum uric acid contents and the activity of renal Na+-K+ ATPase were close to those in the control group. In conclusion, sodium selenite exhibited protective effects on AFB sub( 1)-induced kidney toxicity in broilers.
language: eng
source:
identifier: E-ISSN: 1660-4601 ; DOI: 10.3390/ijerph120911196
fulltext: fulltext
issn:
  • 16604601
  • 1660-4601
url: Link


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titleEffect of Sodium Selenite on Pathological Changes and Renal Functions in Broilers Fed a Diet Containing Aflatoxin B₁.
creatorLiang, Na ; Wang, Fengyuan ; Peng, Xi ; Fang, Jing ; Cui, Hengmin ; Chen, Zhengli ; Lai, Weimin ; Zhou, Yi ; Geng, Yi
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identifierE-ISSN: 1660-4601 ; DOI: 10.3390/ijerph120911196
subjectAflatoxin B1–Toxicity ; Animals–Blood ; Body Weight–Drug Effects ; Chickens–Ultrastructure ; Creatinine–Blood ; Dietary Supplements–Pathology ; Kidney–Prevention & Control ; Kidney Diseases–Toxicity ; Male–Pharmacology ; Poisons–Metabolism ; Sodium Selenite–Pharmacology ; Sodium-Potassium-Exchanging Atpase–Blood ; Trace Elements–Blood ; Uric Acid–Blood ; Poisons ; Trace Elements ; Uric Acid ; Aflatoxin B1 ; Creatinine ; Sodium-Potassium-Exchanging Atpase ; Sodium Selenite ; Aflatoxin B1 ; Broiler ; Pathological Observation ; Renal Function ; Sodium Selenite ; Ultrastructural Observation
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descriptionTo evaluate the renal toxicity of dietary aflatoxin B sub( 1) (AFB sub( 1)) and ameliorating effects of added dietary sodium selenite in broiler, renal histopathological changes, ultrastructural changes, and renal function parameters were monitored at 7, 14, and 21 days of age. Two hundred one-day-old healthy male Avian broilers were divided into four groups, namely control group, AFB sub( 1) group (0.3 mg/kg AFB sub( 1)), +Se group (0.4 mg/kg Se), and AFB sub( 1)+Se group (0.3 mg/kg AFB sub( 1)+0.4 mg/kg Se). Compared with that of the control group, the relative weight of kidney was increased in the AFB sub( 1) group. There were no significant differences between the AFB sub( 1)+Se group and the control group. By histopathological observation, the renal epithelia were swelling and necrosis at 7 and 21 days of age. Ultrastructurally, the lipid droplets and expanded endoplasmic reticulum appeared in the plasma of epithelia cells in the AFB sub( 1) group. Enlarged mitochondria with degenerated cristae were observed in the +Se group. Compared with the control group, the contents of serum creatinine and serum uric acid in the AFB sub( 1) group were increased, while the activity of renal Na+-K+ ATPase was decreased. When 0.4 mg/kg selenium was added into the diet containing 0.3 mg/kg AFB sub( 1), there were no obvious histological changes in the AFB sub( 1)+Se group, and the contents of the serum creatinine and serum uric acid contents and the activity of renal Na+-K+ ATPase were close to those in the control group. In conclusion, sodium selenite exhibited protective effects on AFB sub( 1)-induced kidney toxicity in broilers.
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titleEffect of Sodium Selenite on Pathological Changes and Renal Functions in Broilers Fed a Diet Containing Aflatoxin B₁.
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